Suppression of uncontrollable dendrite growth and water-induced side reactions of Zn metal anodes is crucial for achieving long-lasting cycling stability and facilitating the practical implementations of aqueous Zn-me...Suppression of uncontrollable dendrite growth and water-induced side reactions of Zn metal anodes is crucial for achieving long-lasting cycling stability and facilitating the practical implementations of aqueous Zn-metal batteries.To address these challenges,we report in this study a functional nitro-cellulose interfacial layer(NCIL)on the surface of Zn anodes enlightened by a nitro-coordination chemistry strategy.The NCIL exhibits strong zincophilicity and superior coordination capability with Zn^(2+)due to the highly electronegative and highly nucleophilic nature of the nitro functional group.This characteristic facilitates a rapid Zn-ion desolvation process and homogeneous Zn plating,effectively preventing H_(2) evolution and dendrite formation.Additionally,the negatively charged surface of NCIL acts as a shield,repelling SO_(4)^(2-)anions and inhibiting corrosive reactions on the Zn surface.Remarkably,reversible and stable Zn plating/stripping is achieved for over 5100 h at a current density of 1 mA cm^(-2),which is nearly 30 times longer than that of bare Zn anodes.Furthermore,the Zn/V_(2)O_(5) full cells with the functional interface layer deliver a high-capacity retention of 80.3%for over 10,000 cycles at 5 A g^(-1).This research offers valuable insights for the rational development of advanced protective interface layers in order to achieve ultra-long-lifeZnmetal batteries.展开更多
[Objectives]This study aimed to optimize the ultrasonic-assisted extraction process of quercetin from Flos Sophorae Immaturus.[Methods]The natural product quercetin in Flos Sophorae Immaturus was extracted by ultrason...[Objectives]This study aimed to optimize the ultrasonic-assisted extraction process of quercetin from Flos Sophorae Immaturus.[Methods]The natural product quercetin in Flos Sophorae Immaturus was extracted by ultrasonic-assisted method,and the content of quercetin in the extract was determined by ultraviolet spectrophotometry.The effect of ethanol concentration,solid/liquid ratio,temperature,time and ultrasonic power on the yield of quercetin in Flos Sophorae Immaturus was investigated by using single-factor experiments.Based on the results of single-factor experiments,an orthogonal experiment was designed to optimize the extraction process.The experimental data obtained were subjected to range analysis,analysis of variance and SSR test using SPSS 20.0 software to obtain the optimal extraction process.The results concluded were verified.[Results]The optimal ultrasonic-assisted extraction process for quercetin in Flos Sophorae Immaturus was as follows:temperature of 85℃,time of 30 min,solid/liquid ratio of 1∶20 g/mL,ethanol concentration of 50%.Under the optimal extraction conditions,the yield of quercetin in Flos Sophorae Immaturus was the highest.[Conclusions]This study provides a theoretical basis for the application of quercetin in Flos Sophorae Immaturus.展开更多
[Objectives]To determine the optimum technological conditions of ultrasound-assisted extraction of polysaccharides from Ajuga ciliata Bunge.[Methods]In this study,Ajuga ciliata Bunge was used as raw material,and an or...[Objectives]To determine the optimum technological conditions of ultrasound-assisted extraction of polysaccharides from Ajuga ciliata Bunge.[Methods]In this study,Ajuga ciliata Bunge was used as raw material,and an orthogonal experiment was designed based on the single factor experiment to investigate the effects of ultrasonic time,solid-liquid ratio,ultrasonic temperature and ultrasonic power on the extraction rate of polysaccharides from A.ciliata Bunge(Fujian).Range analysis,variance analysis and SSR test of significant differences between groups were carried out with SPSS 20.0,and the test results were verified.[Results]Under the conditions of ultrasonic temperature of 85℃,ultrasonic time of 80 min,solid-liquid ratio of 1∶15 g/mL and ultrasonic power of 500 W,the yield of polysaccharides from A.ciliata Bunge(Fujian)was the best.[Conclusions]This study can provide theoretical basis for the application of A.ciliata Bunge(Fujian).展开更多
[Objectives] This study was conducted to optimize the extraction process of luteolin, a natural product of Ternate Grape Fern Herb, so as to provide a theoretical research basis for the chemical composition, pharmacol...[Objectives] This study was conducted to optimize the extraction process of luteolin, a natural product of Ternate Grape Fern Herb, so as to provide a theoretical research basis for the chemical composition, pharmacological research and preparation development of Ternate Grape Fern Herb. [Methods] The effects of four factors including ultrasonic extraction time, liquid-to-material ratio, ultrasonic extraction temperature and ethanol concentration on extraction yield of luteolin from Ternate Grape Fern Herb were investigated by the ultrasonic-assisted extraction technology, through a single-factor experiment and an orthogonal experiment based on the single-factor experiment, and the experimental data was subjected to variance analysis and SSR analysis of the significance of differences between groups by SPSS20.0 software to select the optimal extraction process conditions. [Results] The optimal extraction process conditions were as follows: ultrasonic extraction time 25 min, liquid-to-material ratio 25∶1 ml/g, ethanol volume fraction 60%, ultrasonic extraction temperature 85 ℃. [Conclusions] The results were verified, and it was determined that the ultrasonic-assisted extraction process established in this study is reasonable and reliable, and can be used for the extraction of luteolin.展开更多
Due to the integrated development between Chengdu and Chongqing,there are a large number of residents flowing into the two cities from their surrounding areas,so community renewal is imminent.Because of the similarity...Due to the integrated development between Chengdu and Chongqing,there are a large number of residents flowing into the two cities from their surrounding areas,so community renewal is imminent.Because of the similarity in the historical and cultural background of the two places,a comparative analysis of the evolution of community space in Chengdu-Chongqing Region enables Chengdu and Chongqing learn from each other and speed up the pace of renewal.This paper analyzed the evolution of community space in main urban areas of Chengdu and Chongqing.Specifically,the evolution of community space in Chengdu and Chongqing went through three stages.The starting time of community renewal in the two places was very close,but the duration of each stage varied.The second stage of Chengdu continued for a longer time,so its renovation and renewal of the community space was more detailed and thorough,and the emphasis and extension direction of the evolution of the community space were different.The evolution of community space in both Chengdu and Chongqing went through"mechanical renewal of demolition and construction—small-scale gradual renewal",but the path of renewal and development of the community space in Chengdu was faster.This paper,from the perspective of the evolution of community space,put forward the framework and content of community renewal in Chengdu and Chongqing based on community development and elaborated the community research content based on community development.展开更多
Nowadays potential preclinical drugs for the treatment of nonalcoholic steatohepatitis(NASH)have failed to achieve expected therapeutic efficacy because the pathogenic mechanisms are underestimated.Inactive rhomboid p...Nowadays potential preclinical drugs for the treatment of nonalcoholic steatohepatitis(NASH)have failed to achieve expected therapeutic efficacy because the pathogenic mechanisms are underestimated.Inactive rhomboid protein 2(IRHOM2),a promising target for treatment of inflammation-related diseases,contributes to deregulated hepatocyte metabolism-associated nonalcoholic steatohepatitis(NASH)progression.However,the molecular mechanism underlying Irhom2 regulation is still not completely understood.In this work,we identify the ubiquitin-specific protease 13(USP13)as a critical and novel endogenous blocker of IRHOM2,and we also indicate that USP13 is an IRHOM2-interacting protein that catalyzes deubiquitination of Irhom2 in hepatocytes.Hepatocyte-specific loss of the Usp13 disrupts liver metabolic homeostasis,followed by glycometabolic disorder,lipid deposition,increased inflammation,and markedly promotes NASH development.Conversely,transgenic mice with Usp13 overexpression,lentivirus(LV)-or adeno-associated virus(AAV)-driven Usp13 gene therapeutics mitigates NASH in 3 models of rodent.Mechanistically,in response to metabolic stresses,USP13 directly interacts with IRHOM2 and removes its K63-linked ubiquitination induced by ubiquitin-conjugating enzyme E2N(UBC13),a ubiquitin E2 conjugating enzyme,and thus prevents its activation of downstream cascade pathway.USP13 is a potential treatment target for NASH therapy by targeting the Irhom2 signaling pathway.展开更多
We consider the problem of supersonic flow of a Chaplygin gas past a delta wing with a shock or a rarefaction wave attached to the leading edges.The flow under study is described by the three-dimensional steady Euler ...We consider the problem of supersonic flow of a Chaplygin gas past a delta wing with a shock or a rarefaction wave attached to the leading edges.The flow under study is described by the three-dimensional steady Euler system.In conical coordinates,this problem can be reformulated as a boundary value problem for a nonlinear equation of mixed type.The type of this equation depends fully on the solutions of the problem itself,and thus it cannot be determined in advance.We overcome the difficulty by establishing a crucial Lipschitz estimate,and finally prove the unique existence of the solution via the method of continuity.展开更多
基金supported by the National Natural Science Foundation of China (No. 22005216 and 52172241)the General Research Fund of Hong Kong (No. CityU 11308321)Tianjin Research Innovation Project for Postgraduate Students (No.2022BKY130)
文摘Suppression of uncontrollable dendrite growth and water-induced side reactions of Zn metal anodes is crucial for achieving long-lasting cycling stability and facilitating the practical implementations of aqueous Zn-metal batteries.To address these challenges,we report in this study a functional nitro-cellulose interfacial layer(NCIL)on the surface of Zn anodes enlightened by a nitro-coordination chemistry strategy.The NCIL exhibits strong zincophilicity and superior coordination capability with Zn^(2+)due to the highly electronegative and highly nucleophilic nature of the nitro functional group.This characteristic facilitates a rapid Zn-ion desolvation process and homogeneous Zn plating,effectively preventing H_(2) evolution and dendrite formation.Additionally,the negatively charged surface of NCIL acts as a shield,repelling SO_(4)^(2-)anions and inhibiting corrosive reactions on the Zn surface.Remarkably,reversible and stable Zn plating/stripping is achieved for over 5100 h at a current density of 1 mA cm^(-2),which is nearly 30 times longer than that of bare Zn anodes.Furthermore,the Zn/V_(2)O_(5) full cells with the functional interface layer deliver a high-capacity retention of 80.3%for over 10,000 cycles at 5 A g^(-1).This research offers valuable insights for the rational development of advanced protective interface layers in order to achieve ultra-long-lifeZnmetal batteries.
基金Innovation and Entrepreneurship Training Program for Undergraduates of Xiamen Medical College(201812631035,201912631026).
文摘[Objectives]This study aimed to optimize the ultrasonic-assisted extraction process of quercetin from Flos Sophorae Immaturus.[Methods]The natural product quercetin in Flos Sophorae Immaturus was extracted by ultrasonic-assisted method,and the content of quercetin in the extract was determined by ultraviolet spectrophotometry.The effect of ethanol concentration,solid/liquid ratio,temperature,time and ultrasonic power on the yield of quercetin in Flos Sophorae Immaturus was investigated by using single-factor experiments.Based on the results of single-factor experiments,an orthogonal experiment was designed to optimize the extraction process.The experimental data obtained were subjected to range analysis,analysis of variance and SSR test using SPSS 20.0 software to obtain the optimal extraction process.The results concluded were verified.[Results]The optimal ultrasonic-assisted extraction process for quercetin in Flos Sophorae Immaturus was as follows:temperature of 85℃,time of 30 min,solid/liquid ratio of 1∶20 g/mL,ethanol concentration of 50%.Under the optimal extraction conditions,the yield of quercetin in Flos Sophorae Immaturus was the highest.[Conclusions]This study provides a theoretical basis for the application of quercetin in Flos Sophorae Immaturus.
基金Supported by Fujian College Students Innovation and Entrepreneurship Training Program in 2019(201912631026)Innovation and Entrepreneurship Training Program for College Students of Xiamen Medical College(201812631052,201912631057).
文摘[Objectives]To determine the optimum technological conditions of ultrasound-assisted extraction of polysaccharides from Ajuga ciliata Bunge.[Methods]In this study,Ajuga ciliata Bunge was used as raw material,and an orthogonal experiment was designed based on the single factor experiment to investigate the effects of ultrasonic time,solid-liquid ratio,ultrasonic temperature and ultrasonic power on the extraction rate of polysaccharides from A.ciliata Bunge(Fujian).Range analysis,variance analysis and SSR test of significant differences between groups were carried out with SPSS 20.0,and the test results were verified.[Results]Under the conditions of ultrasonic temperature of 85℃,ultrasonic time of 80 min,solid-liquid ratio of 1∶15 g/mL and ultrasonic power of 500 W,the yield of polysaccharides from A.ciliata Bunge(Fujian)was the best.[Conclusions]This study can provide theoretical basis for the application of A.ciliata Bunge(Fujian).
基金Supported by 2019 Undergraduate Innovation and Enterpreneurship Training Program of Fujian Province(201912631026)Undergraduate Innovation and Enterpreneurship Training Program of Xiamen Medical College(201912631057)。
文摘[Objectives] This study was conducted to optimize the extraction process of luteolin, a natural product of Ternate Grape Fern Herb, so as to provide a theoretical research basis for the chemical composition, pharmacological research and preparation development of Ternate Grape Fern Herb. [Methods] The effects of four factors including ultrasonic extraction time, liquid-to-material ratio, ultrasonic extraction temperature and ethanol concentration on extraction yield of luteolin from Ternate Grape Fern Herb were investigated by the ultrasonic-assisted extraction technology, through a single-factor experiment and an orthogonal experiment based on the single-factor experiment, and the experimental data was subjected to variance analysis and SSR analysis of the significance of differences between groups by SPSS20.0 software to select the optimal extraction process conditions. [Results] The optimal extraction process conditions were as follows: ultrasonic extraction time 25 min, liquid-to-material ratio 25∶1 ml/g, ethanol volume fraction 60%, ultrasonic extraction temperature 85 ℃. [Conclusions] The results were verified, and it was determined that the ultrasonic-assisted extraction process established in this study is reasonable and reliable, and can be used for the extraction of luteolin.
基金Sponsored by National Natural Science Foundation of China(51508471)Philosophy and Social Science Program of Sichuan Province(MD16E017)+3 种基金Soft Science Programs of Chengdu City(2015-RK00-00270-ZF)Fundamental Research Funds for the Central Universities for Scientific and Technological Innovation Project(2682017CX016)Teaching Research and Reform Project for Undergraduate Education of Southwest Jiaotong University(201704048)2017 Student Research Training Program(170903)
文摘Due to the integrated development between Chengdu and Chongqing,there are a large number of residents flowing into the two cities from their surrounding areas,so community renewal is imminent.Because of the similarity in the historical and cultural background of the two places,a comparative analysis of the evolution of community space in Chengdu-Chongqing Region enables Chengdu and Chongqing learn from each other and speed up the pace of renewal.This paper analyzed the evolution of community space in main urban areas of Chengdu and Chongqing.Specifically,the evolution of community space in Chengdu and Chongqing went through three stages.The starting time of community renewal in the two places was very close,but the duration of each stage varied.The second stage of Chengdu continued for a longer time,so its renovation and renewal of the community space was more detailed and thorough,and the emphasis and extension direction of the evolution of the community space were different.The evolution of community space in both Chengdu and Chongqing went through"mechanical renewal of demolition and construction—small-scale gradual renewal",but the path of renewal and development of the community space in Chengdu was faster.This paper,from the perspective of the evolution of community space,put forward the framework and content of community renewal in Chengdu and Chongqing based on community development and elaborated the community research content based on community development.
基金supported by National Natural Science Foundation of China(NSFC Grant Nos.81703527 and 82200652)Chongqing Research Program of Basic Research and Frontier Technology(Grant Nos.cstc2017jcyjAX0356,cstc2018jcyjA3686,cstc2018jcyjAX0784,cstc2018jcyjA1472,cstc2018jcyjAX0811,cstc2018jcyjA3533,and KJZD-M201801601,China)+4 种基金School-level Research Program of Chongqing University of Education(Grant Nos.KY201710B and 17GZKP01,China)Advanced Programs of Post-doctor of Chongqing(Grant No.2017LY39,China)Science and Technology Research Program of Chongqing Education Commission of China(Grant Nos.KJQN201901608,KJQN201901615,KJ1601402,and KJZDK202001603)Children's Research Institute of National Center for Schooling Development Programme and Chongqing University of Education(Grant No.CSDP19FSO1108,China)Chongqing Professional Talents Plan for Innovation and Entrepreneurship Demonstration Team(CQCY201903258,China).
文摘Nowadays potential preclinical drugs for the treatment of nonalcoholic steatohepatitis(NASH)have failed to achieve expected therapeutic efficacy because the pathogenic mechanisms are underestimated.Inactive rhomboid protein 2(IRHOM2),a promising target for treatment of inflammation-related diseases,contributes to deregulated hepatocyte metabolism-associated nonalcoholic steatohepatitis(NASH)progression.However,the molecular mechanism underlying Irhom2 regulation is still not completely understood.In this work,we identify the ubiquitin-specific protease 13(USP13)as a critical and novel endogenous blocker of IRHOM2,and we also indicate that USP13 is an IRHOM2-interacting protein that catalyzes deubiquitination of Irhom2 in hepatocytes.Hepatocyte-specific loss of the Usp13 disrupts liver metabolic homeostasis,followed by glycometabolic disorder,lipid deposition,increased inflammation,and markedly promotes NASH development.Conversely,transgenic mice with Usp13 overexpression,lentivirus(LV)-or adeno-associated virus(AAV)-driven Usp13 gene therapeutics mitigates NASH in 3 models of rodent.Mechanistically,in response to metabolic stresses,USP13 directly interacts with IRHOM2 and removes its K63-linked ubiquitination induced by ubiquitin-conjugating enzyme E2N(UBC13),a ubiquitin E2 conjugating enzyme,and thus prevents its activation of downstream cascade pathway.USP13 is a potential treatment target for NASH therapy by targeting the Irhom2 signaling pathway.
文摘We consider the problem of supersonic flow of a Chaplygin gas past a delta wing with a shock or a rarefaction wave attached to the leading edges.The flow under study is described by the three-dimensional steady Euler system.In conical coordinates,this problem can be reformulated as a boundary value problem for a nonlinear equation of mixed type.The type of this equation depends fully on the solutions of the problem itself,and thus it cannot be determined in advance.We overcome the difficulty by establishing a crucial Lipschitz estimate,and finally prove the unique existence of the solution via the method of continuity.
