Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy

AIM: To explore the potential correlation between insulin-like growth factor receptor-1 (IGF-1R) expression and rectal cancer radiosensitivity.

A molecular docking study of Rhizoma Atractylodis and Rhizoma Atractylodis Macrocephalae herbal pair with respect to type 2 diabetes mellitus

Objective:To investigate the action mechanism of Rhizoma Atractylodis (Atractylodes lancea (Thunb.) Dc.) and Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala Koidz.),a two-herb ancient traditional Chinese medicine used to treat type 2 diabetes mellitus,using molecular docking.Methods:The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was searched for compounds in the two herbs and oral bioavailability and drug-likeness values were used to select compounds.The target proteins were selected based on a survey of the literature and related databases,and three receptors closely related to type 2 diabetes were chosen:insulin receptor,peroxisome proliferator activated receptor and dipeptidyl peptidase-Ⅳ.Molecular docking was performed using the CDocker module in Discovery Studio software.The interactions between targets and ligands were observed and analyzed,including the mode of action.Results:Nineteen compounds from the herbal pair interacted with the insulin receptor,the peroxisome proliferator activated receptor and dipeptidyl peptidase-Ⅳ.Among them,10 compounds bound successfully with all three targets,one compound bound with two targets,and eight compounds bound with one target.According to CDocker Interaction Energy,most compounds from the herbal pair had good binding activities with receptors and nine compounds had even higher scores than those of the original ligands.These data indicate that these compounds may be active in reducing blood glucose levels for the treatment of type 2 diabetes.Conclusion:Multiple compounds in the Rhizoma Atractylodis-Rhizoma Atractylodis Macrocephalae herbal pair can affect multiple human targets related to type 2 diabetes.

韩国公共文化研究发展述评及启示——基于KCI及RISS数据库的文献分析

KCI文献数据库和RISS文献数据库是韩国两大知名学术资源平台,对了解韩国学术研究的现状、热点以及未来研究趋势具有重要参考价值。本文基于KCI文献数据库和RISS文献数据库,运用文献分析法系统梳理了与公共文化研究相关的韩国文献数据,对其特点进行了分类分析。结果显示,公共图书馆信息、公共文化设计和公共文化服务是韩国学者关注度最高的三个研究方向。随着第四次产业革命的到来,未来韩国公共文化研究也将围绕数字化、智能化和国际化等主题展开,特别是有关新技术与公共文化发展之间关系的研究将成为重点领域。这一研究结果不仅可以拓宽我国公共文化研究的视野,对我国政府把握政策导向、加强跨学科领域研究及专业人才培养等方面也具有参考价值。

Alkylammonium cations treating and K-Ar dating of illite from mudstones

Two kinds of mudstones from the Tarim Basin and the Tuna Basin were treated with C8 and C18 alkylammonium cations. Both of them were dated by the K-Ar method. One kind of rock contains mainly diagenetic illite, and the other contains mixed layer illite/smectite (I/S). Sample separation and alkylamnionium cations treatment were performed first, and K-Ar dating followed. The result shows that fine-grained minerals have younger K-Ar ages and coarse-grained components have older ages. Plots of K-Ar age versus K2O (%) are linear, the range of diagenetic age can be estimated by extrapolation. The reaction results of the above samples are different after alkylamnionium cations treatments. The samples containing mainly illite show a decrease in K2O and an increase in age by 1-25 Ma, suggesting that preferential exchange of young diagenetic clay rather than detrital clay by alkylamnionium cations, therefore the age of diagenetic illite can be calculated directly by the % K2O and radiogenic 40Ar removed. For the

银行债权治理与资产专用性“敲竹杠”:基于债务重组视角

本文以2008—2017年A股财务困境公司为样本研究资产专用性对债务重组的影响。研究发现:资产专用性越高,发生债务重组的概率越大,二者的显著正相关关系只发生在民营样本;银行参与治理的意愿越强,越能够促进资产专用性与债务重组的正相关关系。研究进一步发现,民营样本中研发投入存在中介效应,国有样本中政府补贴存在遮掩效应。资产专用性能够促进与金融类债权人进行法定债务重组。私下债务重组解决财务困境的市场预期更好,资产专用性高的样本通过私下债务重组更有利于解决财务困境,资产专用性低的样本通过法定债务重组更有利于解决财务困境。