A specialty database has been established at The Hong Kong University of Science and Technology to handle the chemical and biological data of medicinal plants and other natural products from scientific literatures. De...A specialty database has been established at The Hong Kong University of Science and Technology to handle the chemical and biological data of medicinal plants and other natural products from scientific literatures. Designed as a relational system capable of analyzing, comparing, and correlating data, the system can retrieve information in assimilated tabular formats. The database can provide information supports to researchers in the fields of medicinal chemistry, biochemistry, pharmacology, botany and other disciplines of natural products research.展开更多
Three new indole alkaloids, flueindolines A–C(1–3), along with nine known alkaloids(4–12), were isolated from the fruits of Flueggea virosa(Roxb. ex Willd.) Voigt. Compounds 1 and 2 are two new fused tricyclic indo...Three new indole alkaloids, flueindolines A–C(1–3), along with nine known alkaloids(4–12), were isolated from the fruits of Flueggea virosa(Roxb. ex Willd.) Voigt. Compounds 1 and 2 are two new fused tricyclic indole alkaloids possessing an unusual pyrido[1, 2-a]indole framework, and 3 presents a rare spiro(pyrrolizidinyl-oxindole) backbone. Their structures with absolute configurations were elucidated by means of comprehensive spectroscopic analysis, chemical calculation, as well as X-ray crystallography. Chiral resolution and absolute configuration determination of the known compounds 4, 10, and 11 were reported for the first time. The hypothetical biogenetical pathways of 1–3 were herein also proposed.展开更多
文摘A specialty database has been established at The Hong Kong University of Science and Technology to handle the chemical and biological data of medicinal plants and other natural products from scientific literatures. Designed as a relational system capable of analyzing, comparing, and correlating data, the system can retrieve information in assimilated tabular formats. The database can provide information supports to researchers in the fields of medicinal chemistry, biochemistry, pharmacology, botany and other disciplines of natural products research.
基金the National Key R & D Program of China (No. 2018YFC1706200)the National Natural Science Foundation of China (Nos. 81630095, 81622045, and 81803379)+2 种基金the Science & Technology Program of China (No.2019ZX09735002-003)the China Postdoctoral Science Foundation(Nos. 2019T120794, and 2018M633291)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (No. 2017BT01Y036)。
文摘Three new indole alkaloids, flueindolines A–C(1–3), along with nine known alkaloids(4–12), were isolated from the fruits of Flueggea virosa(Roxb. ex Willd.) Voigt. Compounds 1 and 2 are two new fused tricyclic indole alkaloids possessing an unusual pyrido[1, 2-a]indole framework, and 3 presents a rare spiro(pyrrolizidinyl-oxindole) backbone. Their structures with absolute configurations were elucidated by means of comprehensive spectroscopic analysis, chemical calculation, as well as X-ray crystallography. Chiral resolution and absolute configuration determination of the known compounds 4, 10, and 11 were reported for the first time. The hypothetical biogenetical pathways of 1–3 were herein also proposed.
