目的比较肩关节镜手术术后关节镜引导肩峰下置罗哌卡因镇痛泵与静脉镇痛泵的镇痛效果。方法对2017年1月~2019年12月在中山大学孙逸仙纪念医院行单侧肩关节镜手术的患者103例进行回顾性分析,根据术后镇痛策略的不同分为肩峰下置罗哌卡因...目的比较肩关节镜手术术后关节镜引导肩峰下置罗哌卡因镇痛泵与静脉镇痛泵的镇痛效果。方法对2017年1月~2019年12月在中山大学孙逸仙纪念医院行单侧肩关节镜手术的患者103例进行回顾性分析,根据术后镇痛策略的不同分为肩峰下置罗哌卡因镇痛泵组(L组,63例)与舒芬太尼静脉镇痛泵组(S组,40例),比较两组患者术后12 h,24 h及48 h的视觉模拟评分(VAS)。结果两组患者的一般临床资料差异无统计学意义,术后12 h及24 h L组VAS评分明显低于S组(3.1±1.1 vs 4.2±1.2,P<0.001;2.7±0.9 vs 3.1±1.0,P=0.02),术后48 h VAS评分差异无统计学意义(P>0.05);术后L组的PCA次数较S组少(4.5±3.1 vs 5.9±2.6,P=0.02)。结论肩关节术后关节镜引导肩峰下置罗哌卡因镇痛泵较静脉镇痛泵效果好,更有利于患者术后早期肩关节功能锻炼。展开更多
Vitamin C (Vc) is an important antioxidant that helps turtles tolerating stressful environment. This work quantified changes in tissue Vc levels during winter hibernation in the soft-shelled turtle Pelodiscus sinensis...Vitamin C (Vc) is an important antioxidant that helps turtles tolerating stressful environment. This work quantified changes in tissue Vc levels during winter hibernation in the soft-shelled turtle Pelodiscus sinensis , to reveal the stress response pattern of tissue Vc during hibernation and contribute basic data for turtle culture. We sampled juvenile soft-shelled turtles at pre-hibernation (17.0°C mud temperature;MT), during hibernation (5.8°C MT) and after arousal (20.1°C MT) in the field. The transcript levels of the gene encoding L-gulonolactone oxidase (GLO), the key enzyme for Vc synthesis, decreased significantly during hibernation. However, GLO activity did not match the GLO transcription patterns and remained stable during hibernation, and showed temperature-dependent kinetic characteristics. Vitamin C levels in the brain, liver, kidney, and spleen (but not muscle) all decreased significantly during hibernation, but recovered to pre-hibernation levels or even higher levels after arousal. The soft-shelled turtle endured 5 months of hibernation with no significant oxidative damage in most tissues, except in the spleen. Splenic Vc was nearly exhausted during hibernation, accompanied by a significantly elevated malonaldehyde (MDA) level. Although the high level of oxidative damage quickly decreased after arousal, the potential tissue damage in the spleen during hibernation might account for the weakened immune capacity of turtles after hibernation.展开更多
文摘目的比较肩关节镜手术术后关节镜引导肩峰下置罗哌卡因镇痛泵与静脉镇痛泵的镇痛效果。方法对2017年1月~2019年12月在中山大学孙逸仙纪念医院行单侧肩关节镜手术的患者103例进行回顾性分析,根据术后镇痛策略的不同分为肩峰下置罗哌卡因镇痛泵组(L组,63例)与舒芬太尼静脉镇痛泵组(S组,40例),比较两组患者术后12 h,24 h及48 h的视觉模拟评分(VAS)。结果两组患者的一般临床资料差异无统计学意义,术后12 h及24 h L组VAS评分明显低于S组(3.1±1.1 vs 4.2±1.2,P<0.001;2.7±0.9 vs 3.1±1.0,P=0.02),术后48 h VAS评分差异无统计学意义(P>0.05);术后L组的PCA次数较S组少(4.5±3.1 vs 5.9±2.6,P=0.02)。结论肩关节术后关节镜引导肩峰下置罗哌卡因镇痛泵较静脉镇痛泵效果好,更有利于患者术后早期肩关节功能锻炼。
基金Supported by the National Natural Science Foundation of China(Nos.31172383,31670419)the Scientific Start-up Funding for Doctors(No.Z109021614 to CHEN B J)of Northwest A&F University
文摘Vitamin C (Vc) is an important antioxidant that helps turtles tolerating stressful environment. This work quantified changes in tissue Vc levels during winter hibernation in the soft-shelled turtle Pelodiscus sinensis , to reveal the stress response pattern of tissue Vc during hibernation and contribute basic data for turtle culture. We sampled juvenile soft-shelled turtles at pre-hibernation (17.0°C mud temperature;MT), during hibernation (5.8°C MT) and after arousal (20.1°C MT) in the field. The transcript levels of the gene encoding L-gulonolactone oxidase (GLO), the key enzyme for Vc synthesis, decreased significantly during hibernation. However, GLO activity did not match the GLO transcription patterns and remained stable during hibernation, and showed temperature-dependent kinetic characteristics. Vitamin C levels in the brain, liver, kidney, and spleen (but not muscle) all decreased significantly during hibernation, but recovered to pre-hibernation levels or even higher levels after arousal. The soft-shelled turtle endured 5 months of hibernation with no significant oxidative damage in most tissues, except in the spleen. Splenic Vc was nearly exhausted during hibernation, accompanied by a significantly elevated malonaldehyde (MDA) level. Although the high level of oxidative damage quickly decreased after arousal, the potential tissue damage in the spleen during hibernation might account for the weakened immune capacity of turtles after hibernation.
