目的:基于静息态功能磁共振成像(functional magnetic resonance imaging,fMRI)研究慢性期左侧皮层下脑卒中后轻中度手功能障碍(部分偏瘫手)患者运动功能网络的重组模式。方法:招募32例脑卒中后部分偏瘫手患者和40例匹配的健康老年对照...目的:基于静息态功能磁共振成像(functional magnetic resonance imaging,fMRI)研究慢性期左侧皮层下脑卒中后轻中度手功能障碍(部分偏瘫手)患者运动功能网络的重组模式。方法:招募32例脑卒中后部分偏瘫手患者和40例匹配的健康老年对照。采集两组受试者的静息态fMRI数据,并采用Fugl-Meyer腕手运动功能量表评定患者的手功能障碍程度。采用RESTplus软件分析双侧初级运动皮层(primary motor cortex,M1)与全脑功能连接(functional connectivity,FC)的组间差异,并采用Pearson相关分析探究患者的FC模式与手功能评分之间的关系。结果:与健康老年对照相比,部分偏瘫手患者的患侧M1区与健侧感觉运动区、患侧海马和患侧颞中回的FC减弱,并且健侧M1区与患侧中央后回、健侧顶下小叶、患侧颞上回和患侧脑岛的FC也减弱。相关性分析发现,部分偏瘫手患者的健侧M1区与辅助运动区的FC强度与手功能评分正相关(r=0.67,P<0.001)。结论:慢性期左侧皮层下脑卒中后部分偏瘫手患者的运动功能网络发生了广泛的失连接重组,其中,健侧M1区与辅助运动区之间增强的FC可能是提示良好手功能结局的神经影像标记物。展开更多
M2SisN8:Eu2+-based (M=Ca, Sr, Ba) red-emitting phosphors are fabricated at relatively low temperature (1200℃) and atmos- pheric pressure using a simple solid-state reaction process. Several processing parameter...M2SisN8:Eu2+-based (M=Ca, Sr, Ba) red-emitting phosphors are fabricated at relatively low temperature (1200℃) and atmos- pheric pressure using a simple solid-state reaction process. Several processing parameters are systematically investigated to optimize the phosphors structural characterization and photoluminescence performance, including the amount of europium and the properties of the precursor materials. The as-prepared M2SisNs:Eu2+-based (M=Ca, Sr, Ba) phosphors are orange in color and are intensively emitted in the red region of 580-670 nm under 465 nm excitation.展开更多
文摘目的:基于静息态功能磁共振成像(functional magnetic resonance imaging,fMRI)研究慢性期左侧皮层下脑卒中后轻中度手功能障碍(部分偏瘫手)患者运动功能网络的重组模式。方法:招募32例脑卒中后部分偏瘫手患者和40例匹配的健康老年对照。采集两组受试者的静息态fMRI数据,并采用Fugl-Meyer腕手运动功能量表评定患者的手功能障碍程度。采用RESTplus软件分析双侧初级运动皮层(primary motor cortex,M1)与全脑功能连接(functional connectivity,FC)的组间差异,并采用Pearson相关分析探究患者的FC模式与手功能评分之间的关系。结果:与健康老年对照相比,部分偏瘫手患者的患侧M1区与健侧感觉运动区、患侧海马和患侧颞中回的FC减弱,并且健侧M1区与患侧中央后回、健侧顶下小叶、患侧颞上回和患侧脑岛的FC也减弱。相关性分析发现,部分偏瘫手患者的健侧M1区与辅助运动区的FC强度与手功能评分正相关(r=0.67,P<0.001)。结论:慢性期左侧皮层下脑卒中后部分偏瘫手患者的运动功能网络发生了广泛的失连接重组,其中,健侧M1区与辅助运动区之间增强的FC可能是提示良好手功能结局的神经影像标记物。
基金supported by New Century Excellent Talents of the University in China for the financial support(Grant No.NCET-04-0975)
文摘M2SisN8:Eu2+-based (M=Ca, Sr, Ba) red-emitting phosphors are fabricated at relatively low temperature (1200℃) and atmos- pheric pressure using a simple solid-state reaction process. Several processing parameters are systematically investigated to optimize the phosphors structural characterization and photoluminescence performance, including the amount of europium and the properties of the precursor materials. The as-prepared M2SisNs:Eu2+-based (M=Ca, Sr, Ba) phosphors are orange in color and are intensively emitted in the red region of 580-670 nm under 465 nm excitation.