目的了解威海市发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)流行特征和监测现状。方法利用国家疾病监测信息管理系统数据,分析威海市2011—2017年SFTS流行特征。抽取SFTS监测病例中核酸检测阴性且住院...目的了解威海市发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)流行特征和监测现状。方法利用国家疾病监测信息管理系统数据,分析威海市2011—2017年SFTS流行特征。抽取SFTS监测病例中核酸检测阴性且住院期间有发热和血小板减少的病例,进行回顾性调查和抗体检测。结果2011─2017年威海市共报告SFTS病例446例,病死率为6.5%(29/446);病例集中在5—10月,以农民(342/446,76.7%)为主,98.4%(439/446)病例年龄≥40岁;死亡病例年龄中位数(71岁)高于存活病例(62岁)。病例早期核酸检测阴性标本SFTS病毒IgM抗体阳性率较高(9/11,81.8%),回顾性调查采集标本IgG抗体阳性率、抗体滴度均较高。81.8%病例的双份标本IgG抗体呈阳转或4倍及以上升高。结论威海市SFTS年发病数呈波动性变化,病例以中老年农民为主。病例双份标本中高SFTS病毒抗体检出率,提示核酸检测阴性SFTS疑似病例应慎重排除。展开更多
A recently developed time-resolved coherent anti-Stokes Raman scattering(tr-CARS) technique allows the measurement of vibrational coherences with high frequency differences with the ambient environment.The method is b...A recently developed time-resolved coherent anti-Stokes Raman scattering(tr-CARS) technique allows the measurement of vibrational coherences with high frequency differences with the ambient environment.The method is based on the short spatial extension of femtosecond pulses with a broadband tunable nonlinear optical parametric amplifier(NOPA) and an internal time delay between the probe and pump/Stokes pulse pair in the CARS process.The different beat frequencies between Raman modes can be selectively detected as oscillations in the tr-CARS transient signal with the broadband tunable NOPA.In this work,we aim at the Raman C-H stretching vibrations from 2800 cm 1 to 3000 cm 1,within which the different vibrational modes in both ethanol and methanol are selectively excited and simultaneously detected.The high time resolution of the experimental set-up allows one to monitor the vibrational coherence dynamics and to observe the quantum beat phenomena on a terahertz scale.This investigation indicates that the femtosecond tr-CARS technique is a powerful tool for the real-time monitoring and detection of molecular and biological agents,including airborne contaminants such as bacterial spores,viruses and their toxins.展开更多
A variant of all-resonant CARS named electronic-resonant enhancement CARS(ERE-CARS) is applied to measure the methanol-water solution concentration at room temperature.The measurements are performed using the ERE-CARS...A variant of all-resonant CARS named electronic-resonant enhancement CARS(ERE-CARS) is applied to measure the methanol-water solution concentration at room temperature.The measurements are performed using the ERE-CARS signal of the Raman vibrations near the C-H stretching modes(at 2835 and 2942 cm 1) in methanol.By changing the timing(t>0) of the laser pulses of this non-degenerate four wave mixing technique,the concentration information based on the vibrational dynamics of the C-H bonds can be successfully detected as the frequency-spread dephasing rate during the first few hundred fs in the ERE-CARS signal with high sensitivity and accuracy.Femtosecond time-resolved ERE-CARS technique is applied to the concentration analysis of a mixture of the organic solution.This investigation indicates that femtosecond time-resolved ERE-CARS technique might be a powerful tool for real-time detection for solution concentration of different liquids.展开更多
文摘目的了解威海市发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)流行特征和监测现状。方法利用国家疾病监测信息管理系统数据,分析威海市2011—2017年SFTS流行特征。抽取SFTS监测病例中核酸检测阴性且住院期间有发热和血小板减少的病例,进行回顾性调查和抗体检测。结果2011─2017年威海市共报告SFTS病例446例,病死率为6.5%(29/446);病例集中在5—10月,以农民(342/446,76.7%)为主,98.4%(439/446)病例年龄≥40岁;死亡病例年龄中位数(71岁)高于存活病例(62岁)。病例早期核酸检测阴性标本SFTS病毒IgM抗体阳性率较高(9/11,81.8%),回顾性调查采集标本IgG抗体阳性率、抗体滴度均较高。81.8%病例的双份标本IgG抗体呈阳转或4倍及以上升高。结论威海市SFTS年发病数呈波动性变化,病例以中老年农民为主。病例双份标本中高SFTS病毒抗体检出率,提示核酸检测阴性SFTS疑似病例应慎重排除。
基金supported by the National Natural Science Foundation of China (Grant Nos. 60878018 and 61008023)the Program of Excellentat Harbin Institute of Technology
文摘A recently developed time-resolved coherent anti-Stokes Raman scattering(tr-CARS) technique allows the measurement of vibrational coherences with high frequency differences with the ambient environment.The method is based on the short spatial extension of femtosecond pulses with a broadband tunable nonlinear optical parametric amplifier(NOPA) and an internal time delay between the probe and pump/Stokes pulse pair in the CARS process.The different beat frequencies between Raman modes can be selectively detected as oscillations in the tr-CARS transient signal with the broadband tunable NOPA.In this work,we aim at the Raman C-H stretching vibrations from 2800 cm 1 to 3000 cm 1,within which the different vibrational modes in both ethanol and methanol are selectively excited and simultaneously detected.The high time resolution of the experimental set-up allows one to monitor the vibrational coherence dynamics and to observe the quantum beat phenomena on a terahertz scale.This investigation indicates that the femtosecond tr-CARS technique is a powerful tool for the real-time monitoring and detection of molecular and biological agents,including airborne contaminants such as bacterial spores,viruses and their toxins.
基金supported by the National Natural Science Foundation of China (Grant No. 61008023)the Program of Excellent at Harbin Institute of Technology
文摘A variant of all-resonant CARS named electronic-resonant enhancement CARS(ERE-CARS) is applied to measure the methanol-water solution concentration at room temperature.The measurements are performed using the ERE-CARS signal of the Raman vibrations near the C-H stretching modes(at 2835 and 2942 cm 1) in methanol.By changing the timing(t>0) of the laser pulses of this non-degenerate four wave mixing technique,the concentration information based on the vibrational dynamics of the C-H bonds can be successfully detected as the frequency-spread dephasing rate during the first few hundred fs in the ERE-CARS signal with high sensitivity and accuracy.Femtosecond time-resolved ERE-CARS technique is applied to the concentration analysis of a mixture of the organic solution.This investigation indicates that femtosecond time-resolved ERE-CARS technique might be a powerful tool for real-time detection for solution concentration of different liquids.
