目的探讨磁共振血管造影(magnetic resonance angiography,MRA)中侧枝血管与急性卒中机械取栓术后预后间的关系。材料与方法前瞻性纳入接受机械取栓治疗的急性卒中患者。所有患者均于治疗前及治疗后24 h内接受头颅MRI平扫和MRA检查。3...目的探讨磁共振血管造影(magnetic resonance angiography,MRA)中侧枝血管与急性卒中机械取栓术后预后间的关系。材料与方法前瞻性纳入接受机械取栓治疗的急性卒中患者。所有患者均于治疗前及治疗后24 h内接受头颅MRI平扫和MRA检查。3个月后的预后情况根据改良Rankin量表(modified Rankin Scale,mRS)评估,mRS0~2为预后良好组,mRS3~6为预后不良组。统计学方法分析预后良好组与不良组之间侧裂及软脑膜的侧枝血管的差异。结果共55例动脉闭塞的卒中患者纳入分析(侧裂侧枝血管不丰富者52例,软脑膜侧枝血管不丰富者45例)。侧裂血管和软脑膜血管不丰富的患者,预后良好组的入院NIHSS评分(10.06±4.65 vs 14.25±4.91;P=0.006)、术前梗死体积(13.61±10.99 vs 59.80±92.74;P=0.006)均低于预后不良组。多元逻辑回归分析显示年龄、软脑膜的侧枝循环是预测预后的独立预测因子(OR=1.094,95%CI=1.025~1.168,P=0.007;OR=9.542,95%CI=1.812~50.245,P=0.008)。预后良好组的梗死增长体积(术前vs术后:14.15±10.73 vs 21.39±17.41)小于预后不良组(术前vs术后:16.88±16.64 vs 57.27±56.67),然而多元逻辑回归分析显示术后梗死体积对预测卒中预后无显著意义(OR=1.094,95%CI=1.025~1.168,P=0.154)。结论磁共振血管造影侧枝血管可用于评估卒中预后,尤其是软脑膜的侧枝循环可预测卒中预后,而术后卒中梗死体积与预后的关系仍需进一步研究。展开更多
目的探讨DWI梗死体积与FVH-DWI不匹配、预后间的相关性。方法前瞻性纳入2017年1月-2018年12月收住入院并接受血管再通治疗患者38例。均于治疗前及治疗后24h内接受MRI检查。收集所有患者的FVH-DWI不匹配、DWI体积(VDWI)、3个月功能预后(...目的探讨DWI梗死体积与FVH-DWI不匹配、预后间的相关性。方法前瞻性纳入2017年1月-2018年12月收住入院并接受血管再通治疗患者38例。均于治疗前及治疗后24h内接受MRI检查。收集所有患者的FVH-DWI不匹配、DWI体积(VDWI)、3个月功能预后(mRS评分)及一般临床资料等。统计学方法分析DWI梗死体积与FVH-DWI不匹配、卒中预后之间的相关性,应用多元逻辑回归分析预测卒中预后的独立预测因子。结果与无FVH-DWI不匹配组(n=15)相比,FVH-DWI不匹配组(n=23)治疗前VDWI(15.13±22.96vs56.88±50.99;P=0.008)较小、治疗后VDWI(32.15±39.38 vs 101.40±86.39;P=0.009)较小、VDWI-G较小(17.01±23.36 vs 44.52±41.69;P=0.031)。Spearman相关分析显示治疗前VDWI(r=0.540;P=0.000)、治疗后VDWI(r=0.579;P=0.000)、VDWI-G(r=0.489;P=0.002)与FVH-DWI不匹配呈正相关。治疗前VDWI(r=0.414;P=0.010)、治疗后VDWI(r=0.486;P=0.002)、VDWI-G(r=0.467;P=0.003)、FVH-DWI不匹配(r=0.327;P=0.045)均与3个月mRS间呈正相关。逻辑回归分析显示治疗后VDWI为预测卒中预后的独立预测因子(OR95%CI):1.031(1.006~1.057);(P=0.017)。结论综合评估DWI梗死体积、FVH-DWI不匹配,尤其是治疗后DWI梗死体积可以有效的判断卒中的功能预后、指导治疗。展开更多
Macro-microscopic tectonic analysis and lithologic features show that the gold-bearing breccia bodies in the Shuangwang gold deposit, for hydrofracturing of the deep-sourced and alkali-rich fluids in the Devonian sodi...Macro-microscopic tectonic analysis and lithologic features show that the gold-bearing breccia bodies in the Shuangwang gold deposit, for hydrofracturing of the deep-sourced and alkali-rich fluids in the Devonian sodic rock series, are identified as hydrofracturing breccia bodies. Since the Indosinian, intracontinental collisional orogenesis results in multiple fracturings and magmatic emplacements in the Qinling area. Deep-sourced fluids resulting from deep fractures and granitoid magmatic intrusion are of a supercritical nature. Joint action between the fluid-rock system and structures leads to hydrofracturing and ore formation of the gold deposit. Firstly, the progressive coaxial compression caused the competent sodic rock series and the incompetent pelitic rock series to be deformed and partitioned. Lens-like weak-strain domains are hence formed and distributed at the approximate equidistance zones and the linear strong-strain zones, respectively. Subsequently, the progressive non-coaxial shearing and right-lateral and high-angle oblique thrusting lead to the most developed fracture system in the core of the weak-strain domain to turn from compression to extension and to link up with the deep fracture systems. The periodical huge pressure decline in the pumping center causes the deep-sourced confined fluids to develop periodic tectonic pumping, hydrofracturing and precipitation-healing in the sodic rock series. The gold-bearinghydrofracturing breccia bodies are hence ultimately formed at near-equidistance tectonic lenses. On the basis of the above model, the predicted concealed gold-bearing hydrofracturing breccia bodies have been preliminarily validated by latest drillings.展开更多
The Tertiary is the main mineralization period in the Lanping-Simao Basin.The deposits are rich in organic matter and the organie matter takes part in the metal and nonmetal mineralization process. The organic mineral...The Tertiary is the main mineralization period in the Lanping-Simao Basin.The deposits are rich in organic matter and the organie matter takes part in the metal and nonmetal mineralization process. The organic mineralization is controlled by the tectonic setting.Different tectonic setting results in different mineralization and type of organic matters.展开更多
文摘目的探讨磁共振血管造影(magnetic resonance angiography,MRA)中侧枝血管与急性卒中机械取栓术后预后间的关系。材料与方法前瞻性纳入接受机械取栓治疗的急性卒中患者。所有患者均于治疗前及治疗后24 h内接受头颅MRI平扫和MRA检查。3个月后的预后情况根据改良Rankin量表(modified Rankin Scale,mRS)评估,mRS0~2为预后良好组,mRS3~6为预后不良组。统计学方法分析预后良好组与不良组之间侧裂及软脑膜的侧枝血管的差异。结果共55例动脉闭塞的卒中患者纳入分析(侧裂侧枝血管不丰富者52例,软脑膜侧枝血管不丰富者45例)。侧裂血管和软脑膜血管不丰富的患者,预后良好组的入院NIHSS评分(10.06±4.65 vs 14.25±4.91;P=0.006)、术前梗死体积(13.61±10.99 vs 59.80±92.74;P=0.006)均低于预后不良组。多元逻辑回归分析显示年龄、软脑膜的侧枝循环是预测预后的独立预测因子(OR=1.094,95%CI=1.025~1.168,P=0.007;OR=9.542,95%CI=1.812~50.245,P=0.008)。预后良好组的梗死增长体积(术前vs术后:14.15±10.73 vs 21.39±17.41)小于预后不良组(术前vs术后:16.88±16.64 vs 57.27±56.67),然而多元逻辑回归分析显示术后梗死体积对预测卒中预后无显著意义(OR=1.094,95%CI=1.025~1.168,P=0.154)。结论磁共振血管造影侧枝血管可用于评估卒中预后,尤其是软脑膜的侧枝循环可预测卒中预后,而术后卒中梗死体积与预后的关系仍需进一步研究。
文摘目的探讨DWI梗死体积与FVH-DWI不匹配、预后间的相关性。方法前瞻性纳入2017年1月-2018年12月收住入院并接受血管再通治疗患者38例。均于治疗前及治疗后24h内接受MRI检查。收集所有患者的FVH-DWI不匹配、DWI体积(VDWI)、3个月功能预后(mRS评分)及一般临床资料等。统计学方法分析DWI梗死体积与FVH-DWI不匹配、卒中预后之间的相关性,应用多元逻辑回归分析预测卒中预后的独立预测因子。结果与无FVH-DWI不匹配组(n=15)相比,FVH-DWI不匹配组(n=23)治疗前VDWI(15.13±22.96vs56.88±50.99;P=0.008)较小、治疗后VDWI(32.15±39.38 vs 101.40±86.39;P=0.009)较小、VDWI-G较小(17.01±23.36 vs 44.52±41.69;P=0.031)。Spearman相关分析显示治疗前VDWI(r=0.540;P=0.000)、治疗后VDWI(r=0.579;P=0.000)、VDWI-G(r=0.489;P=0.002)与FVH-DWI不匹配呈正相关。治疗前VDWI(r=0.414;P=0.010)、治疗后VDWI(r=0.486;P=0.002)、VDWI-G(r=0.467;P=0.003)、FVH-DWI不匹配(r=0.327;P=0.045)均与3个月mRS间呈正相关。逻辑回归分析显示治疗后VDWI为预测卒中预后的独立预测因子(OR95%CI):1.031(1.006~1.057);(P=0.017)。结论综合评估DWI梗死体积、FVH-DWI不匹配,尤其是治疗后DWI梗死体积可以有效的判断卒中的功能预后、指导治疗。
文摘目的研究妊娠上调的非泛素性钙调蛋白激酶(Pregnancy-upregulated nonubiquitous calmodulin kinase,PNCK)在鼻咽癌组织中的表达以及对鼻咽癌细胞增殖和凋亡的作用。方法采用免疫组织化学方法检测鼻咽癌癌组织和正常组织中PNCK表达水平。构建慢病毒载体干扰PNCK基因表达,并采用Real time PCR和免疫印迹结果证实,采用MTT方法、流式细胞术、Caspase3和Caspase7活性检测鼻咽癌肿瘤细胞增殖和凋亡的变化。结果免疫组织化学结果显示PNCK蛋白在鼻咽癌癌组织中呈特异性高表达。Real time PCR和免疫印迹结果证实慢病毒成功干扰鼻咽癌CNE-2Z细胞中PNCK表达(PNCK基因在mRNA和蛋白水平表达受到显著抑制)。MTT检测结果显示抑制PNCK表达抑制CNE-2Z细胞增殖。此外,干扰PNCK表达引起CNE-2Z细胞Caspase3和Caspase7活性上升,流式细胞术表明干扰PNCK基因表达可以促进CNE-2Z细胞凋亡。结论干扰PNCK基因表达抑制鼻咽癌细胞增殖并诱导肿瘤细胞凋亡,可能是治疗鼻咽癌的潜在靶点。
基金the 305 State Key Sci&Tech Program(Grant No.2003BA612A-06-01)the Key Innovation Oriented Program(GrantNo.KZCX3-SW-137)of the Chinese Academy of Sciences.
文摘Macro-microscopic tectonic analysis and lithologic features show that the gold-bearing breccia bodies in the Shuangwang gold deposit, for hydrofracturing of the deep-sourced and alkali-rich fluids in the Devonian sodic rock series, are identified as hydrofracturing breccia bodies. Since the Indosinian, intracontinental collisional orogenesis results in multiple fracturings and magmatic emplacements in the Qinling area. Deep-sourced fluids resulting from deep fractures and granitoid magmatic intrusion are of a supercritical nature. Joint action between the fluid-rock system and structures leads to hydrofracturing and ore formation of the gold deposit. Firstly, the progressive coaxial compression caused the competent sodic rock series and the incompetent pelitic rock series to be deformed and partitioned. Lens-like weak-strain domains are hence formed and distributed at the approximate equidistance zones and the linear strong-strain zones, respectively. Subsequently, the progressive non-coaxial shearing and right-lateral and high-angle oblique thrusting lead to the most developed fracture system in the core of the weak-strain domain to turn from compression to extension and to link up with the deep fracture systems. The periodical huge pressure decline in the pumping center causes the deep-sourced confined fluids to develop periodic tectonic pumping, hydrofracturing and precipitation-healing in the sodic rock series. The gold-bearinghydrofracturing breccia bodies are hence ultimately formed at near-equidistance tectonic lenses. On the basis of the above model, the predicted concealed gold-bearing hydrofracturing breccia bodies have been preliminarily validated by latest drillings.
文摘The Tertiary is the main mineralization period in the Lanping-Simao Basin.The deposits are rich in organic matter and the organie matter takes part in the metal and nonmetal mineralization process. The organic mineralization is controlled by the tectonic setting.Different tectonic setting results in different mineralization and type of organic matters.
