In this paper,the 99mTc-octreotide scintimammography as a useful complementary technique of mammography was evaluated in diagnosing breast cancers.The 45 breast lesions were consecutively detected by mammography,and 9...In this paper,the 99mTc-octreotide scintimammography as a useful complementary technique of mammography was evaluated in diagnosing breast cancers.The 45 breast lesions were consecutively detected by mammography,and 99mTc-octreotide scintimammography,and both combination technique on the basis of self-examination,physical examination.Clinical diagnosis was confirmed by histopathologic analysis.Radioactivity uptake ratios for tumor vs normal breast tissues (T/NT) were calculated using regions of interest.In the breast cancer groups and the benign lesion groups,the average uptake ratios of the 99mTc-octreotide were 1.63±0.19 and 1.09±0.13,respectively,and t was 9.638 (P<0.001).Based on sensitivity,specificity,accuracy,positive predicting value,and negative predicting value,99mTc-octreotide scintimammography was 87%,79%,84%,90%,and 73%,the mammography was 65%,64%,64%,80%,and 45%,and both combination was 95%,100%,97%,100% and 92%,respectively.This showed that the 99mTc-octreotide scintimammography was more useful than mammography in the evaluating suspected breast cancers,and the combination technique can accurately discriminate lesions.展开更多
CT has rather low accuracy for the follow-up of tumors after therapy. This study was to determine whether the diagnostic accuracy can be improved with 99mTc-HL91 SPECT in comparison with parallel results of CT imaging...CT has rather low accuracy for the follow-up of tumors after therapy. This study was to determine whether the diagnostic accuracy can be improved with 99mTc-HL91 SPECT in comparison with parallel results of CT imaging. Thirty patients of lung cancer or head & neck cancer, suspected of recurrences on clinical symptoms and CT during clinical follow-up after therapy, underwent 99mTc-HL91 SPECT. The radioactivity ratios of tumor to normal tissues (T/NT) were calculated using the region of interest technique. Results of 99mTc-HL91 SPECT were verified by histopathology. The 99mTc-HL91 average uptake ratios of T/NT in the group of recurrent lesions and non-recurrent lesions were 1.58±0.16 and 1.18±0.14, respectively. A significant difference was found between T/NT data of the two phases (t=4.87, P<0.001). The 99mTc-HL91 SPECT shows sensitivity of 72.73%, specificity of 89.47% and accuracy of 83.83% for differentiating recurrent lesion, while the CT shows sensitivity of 63.63%, specificity of 84.21% and accuracy of 76.67%. A combination of 99mTc-HL91 SPECT and CT for 21 patients with lung cancers or head & neck cancers with congruent results shows sensitivity of 100%, specificity of 94.12% and accuracy of 95.23%. It is concluded that 99mTc-HL91 SPECT may play a role in differentiating recurrent lesions in patients with lung cancer and head & neck cancer. Furthermore, the combination of CT and 99mTc-HL91 SPECT is a more effective method for diagnosing recurrence of lung cancer and head & neck cancer.展开更多
目的分析国内外发表的电烧伤相关文献,探讨电烧伤研究的热点与前沿。方法采用文献计量学方法。分别检索中国知网、万方数据库、维普数据库及Web of Science数据库核心合集中2013年1月1日—2022年12月31日发表的与电烧伤相关的中英文文献...目的分析国内外发表的电烧伤相关文献,探讨电烧伤研究的热点与前沿。方法采用文献计量学方法。分别检索中国知网、万方数据库、维普数据库及Web of Science数据库核心合集中2013年1月1日—2022年12月31日发表的与电烧伤相关的中英文文献,采用CiteSpace6.2.R2软件进行分析。分别统计中英文文献的发文量、发文作者、国家与机构,对关键词进行共现分析并在此基础上进行突现情况分析和聚类分析,将关键词按时间排序得到聚类时间线图,探讨电烧伤领域研究现状和热点的演变过程。结果在Web of Science数据库核心合集中检索出398篇英文文献;在中国知网、万方数据库、维普数据库检索并查重后得到523篇中文文献。2013—2022年,电烧伤领域英文文献发文量呈稳步上升趋势,中文文献发文量呈下降并趋于平稳趋势。中文文献中共302位作者以第1作者发表电烧伤相关文章,发文量≥3篇的核心作者共有17位;英文文献中共320位作者以第1作者发表电烧伤相关文章。共有65个国家进行电烧伤相关研究,美国是与其他国家合作最多、发文量最多的国家。国内外共512家机构发表电烧伤相关文章,发表中文和英文文章数量最多的机构分别是上海电力医院(14篇)和韩国翰林大学(11篇)。共纳入1176个中文关键词、1068个英文关键词进行共现分析,排除与检索词相关的关键词后,中文文献中出现频次排前3的关键词为外科皮瓣、创面修复、护理,英文文献中出现频次排前3的关键词是management、epidemiology、children。中文文献关键词分析得到10个聚类,最大的聚类是创面愈合,其次是临床效果、外科皮瓣;英文文献关键词分析得到7个聚类,最大的聚类是reconstructive surgical procedures,其次是chronic pain、shock。中文文献中持续存在的聚类为创面愈合、临床效果等,近2年出现的突现节点为手术时机、四肢电烧伤、增生性瘢痕等;英文文献中持续存在的聚类为reconstructive surgical procedures、chronic pain等,近2年出现的突现节点为predictors、burn management等。中文文献中突现持续时间最长(2017—2021年)的关键词是腕部电烧伤,突现强度最高的关键词是皮瓣修复;英文文献中突现持续时间最长(2019—2022年)的关键词是voltage,突现强度最高的关键词是prevention。结论国内外电烧伤研究方向与热点存在相似性和差异性。外科皮瓣修复是国内外电烧伤领域的共同研究热点,目前国内研究侧重于创面愈合、腕部电烧伤等方面,国外研究则聚焦在治疗管理、流行病学、重建等方面。展开更多
基金Supported by Xiamen Municipal Health Bureau (Grant No. WSK0614)
文摘In this paper,the 99mTc-octreotide scintimammography as a useful complementary technique of mammography was evaluated in diagnosing breast cancers.The 45 breast lesions were consecutively detected by mammography,and 99mTc-octreotide scintimammography,and both combination technique on the basis of self-examination,physical examination.Clinical diagnosis was confirmed by histopathologic analysis.Radioactivity uptake ratios for tumor vs normal breast tissues (T/NT) were calculated using regions of interest.In the breast cancer groups and the benign lesion groups,the average uptake ratios of the 99mTc-octreotide were 1.63±0.19 and 1.09±0.13,respectively,and t was 9.638 (P<0.001).Based on sensitivity,specificity,accuracy,positive predicting value,and negative predicting value,99mTc-octreotide scintimammography was 87%,79%,84%,90%,and 73%,the mammography was 65%,64%,64%,80%,and 45%,and both combination was 95%,100%,97%,100% and 92%,respectively.This showed that the 99mTc-octreotide scintimammography was more useful than mammography in the evaluating suspected breast cancers,and the combination technique can accurately discriminate lesions.
基金Supported by Department of Science and Technology of Xiamen City (Grant No. 3502Z20052017).
文摘CT has rather low accuracy for the follow-up of tumors after therapy. This study was to determine whether the diagnostic accuracy can be improved with 99mTc-HL91 SPECT in comparison with parallel results of CT imaging. Thirty patients of lung cancer or head & neck cancer, suspected of recurrences on clinical symptoms and CT during clinical follow-up after therapy, underwent 99mTc-HL91 SPECT. The radioactivity ratios of tumor to normal tissues (T/NT) were calculated using the region of interest technique. Results of 99mTc-HL91 SPECT were verified by histopathology. The 99mTc-HL91 average uptake ratios of T/NT in the group of recurrent lesions and non-recurrent lesions were 1.58±0.16 and 1.18±0.14, respectively. A significant difference was found between T/NT data of the two phases (t=4.87, P<0.001). The 99mTc-HL91 SPECT shows sensitivity of 72.73%, specificity of 89.47% and accuracy of 83.83% for differentiating recurrent lesion, while the CT shows sensitivity of 63.63%, specificity of 84.21% and accuracy of 76.67%. A combination of 99mTc-HL91 SPECT and CT for 21 patients with lung cancers or head & neck cancers with congruent results shows sensitivity of 100%, specificity of 94.12% and accuracy of 95.23%. It is concluded that 99mTc-HL91 SPECT may play a role in differentiating recurrent lesions in patients with lung cancer and head & neck cancer. Furthermore, the combination of CT and 99mTc-HL91 SPECT is a more effective method for diagnosing recurrence of lung cancer and head & neck cancer.
