目的探讨一种踝关节保护支具(protective ankle brace,PAB)对空降兵伞降过程中着陆阶段踝关节的保护作用,为降低空降兵着陆阶段踝关节损伤提供有效的防护手段。方法选取空降兵作为受试者,佩戴PBA前后从1.5 m、2 m高度的空降兵地面动作...目的探讨一种踝关节保护支具(protective ankle brace,PAB)对空降兵伞降过程中着陆阶段踝关节的保护作用,为降低空降兵着陆阶段踝关节损伤提供有效的防护手段。方法选取空降兵作为受试者,佩戴PBA前后从1.5 m、2 m高度的空降兵地面动作训练高台跳出,保持标准弯腰屈膝姿势接触训练场缓冲地面。受试者共完成4次模拟着陆试验,分别为1.5 m戴PAB(1.5 m PAB组)、2 m戴PAB(2 m PAB组)、1.5 m不戴PAB(1.5 m对照组)、2 m不戴PAB(2 m对照组)。通过表面肌电仪记录受试者双侧胫骨前肌、腓骨长短肌和腓肠肌的肌肉电信号,计算最大随意收缩百分比(percentage of maximal voluntary electrical activation,MVE%),并进行测试分析。结果最终纳入61名受试者。相同高度不同踝关节防护状态时,1.5 m PAB组的双侧胫骨前肌、腓肠肌MVE%值均小于1.5 m对照组,差异有统计学意义(t=2.45、2.74、2.35,P=0.017、0.008、0.022);而1.5 m PAB组的双侧腓骨长短肌的MVE%值均大于1.5 m对照组,差异有统计学意义(t=5.28、4.56,P均<0.001)。2 m PAB组左侧胫骨前肌、左侧腓肠肌的MVE%值小于2 m对照组,差异有统计学意义(t=2.21、0.53、4.35,P=0.031、0.598、<0.001);而2 m PAB组的双侧腓骨长短肌MVE%值均大于2 m对照组,且差异有统计学意义(t=4.92、6.31,P均<0.001)。不同高度相同踝关节防护状态时,1.5 m PAB组的双侧胫骨前肌、腓肠肌、腓骨长短肌的MVE%值均小于2 m PAB组,差异有统计学意义(t=3.56~4.94,P均≤0.001)。1.5 m对照组的双侧胫骨前肌、腓肠肌、腓骨长短肌的MVE%值均小于2 m对照组,差异有统计学意义(t=2.30~5.85,P均<0.05)。结论PAB能够降低空降兵伞降过程中着陆阶段踝关节的损伤,起到较好的保护作用。展开更多
Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite ...Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite (icariin-CS/HA) using freeze-drying technigue. Characteristics of morphology, mechanical properties, biocompatibility, drug release behavior and bone repair abilities in vivo were evaluated. The results show that drug loading process of icariin did not affect physical structure of CS/HA composite significantly but decreased mechanical properies of CS/HA composite, which happened with a high dosage; icariin-CS/HA had favorable cell compatibility and promoted osteogenic differentiation of hBMSCs; the controlled release of icariin was satisfactory and the release retained after 90 d in vitro. In addition, icariin-CS/HA scaffolds had favorable osteoconduction and osteoinduction in vivo, and could fill bone defect sites and stimulate newborn bone tissues formation at early stage. On the basis of these data, icariin-CS/HA is believed to be an optical bone repair scaffold for tissue engineering.展开更多
文摘目的探讨一种踝关节保护支具(protective ankle brace,PAB)对空降兵伞降过程中着陆阶段踝关节的保护作用,为降低空降兵着陆阶段踝关节损伤提供有效的防护手段。方法选取空降兵作为受试者,佩戴PBA前后从1.5 m、2 m高度的空降兵地面动作训练高台跳出,保持标准弯腰屈膝姿势接触训练场缓冲地面。受试者共完成4次模拟着陆试验,分别为1.5 m戴PAB(1.5 m PAB组)、2 m戴PAB(2 m PAB组)、1.5 m不戴PAB(1.5 m对照组)、2 m不戴PAB(2 m对照组)。通过表面肌电仪记录受试者双侧胫骨前肌、腓骨长短肌和腓肠肌的肌肉电信号,计算最大随意收缩百分比(percentage of maximal voluntary electrical activation,MVE%),并进行测试分析。结果最终纳入61名受试者。相同高度不同踝关节防护状态时,1.5 m PAB组的双侧胫骨前肌、腓肠肌MVE%值均小于1.5 m对照组,差异有统计学意义(t=2.45、2.74、2.35,P=0.017、0.008、0.022);而1.5 m PAB组的双侧腓骨长短肌的MVE%值均大于1.5 m对照组,差异有统计学意义(t=5.28、4.56,P均<0.001)。2 m PAB组左侧胫骨前肌、左侧腓肠肌的MVE%值小于2 m对照组,差异有统计学意义(t=2.21、0.53、4.35,P=0.031、0.598、<0.001);而2 m PAB组的双侧腓骨长短肌MVE%值均大于2 m对照组,且差异有统计学意义(t=4.92、6.31,P均<0.001)。不同高度相同踝关节防护状态时,1.5 m PAB组的双侧胫骨前肌、腓肠肌、腓骨长短肌的MVE%值均小于2 m PAB组,差异有统计学意义(t=3.56~4.94,P均≤0.001)。1.5 m对照组的双侧胫骨前肌、腓肠肌、腓骨长短肌的MVE%值均小于2 m对照组,差异有统计学意义(t=2.30~5.85,P均<0.05)。结论PAB能够降低空降兵伞降过程中着陆阶段踝关节的损伤,起到较好的保护作用。
基金Supported by the National Basic Research Program (Grant No. 2009CB930000)National Natural Science Foundation of China (Grant No. 30700180)Chinese Postdoctoral Science Foundation (Grant No. 20060390206)
文摘Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite (icariin-CS/HA) using freeze-drying technigue. Characteristics of morphology, mechanical properties, biocompatibility, drug release behavior and bone repair abilities in vivo were evaluated. The results show that drug loading process of icariin did not affect physical structure of CS/HA composite significantly but decreased mechanical properies of CS/HA composite, which happened with a high dosage; icariin-CS/HA had favorable cell compatibility and promoted osteogenic differentiation of hBMSCs; the controlled release of icariin was satisfactory and the release retained after 90 d in vitro. In addition, icariin-CS/HA scaffolds had favorable osteoconduction and osteoinduction in vivo, and could fill bone defect sites and stimulate newborn bone tissues formation at early stage. On the basis of these data, icariin-CS/HA is believed to be an optical bone repair scaffold for tissue engineering.
