Truttmann MC et al.[1] recently reported that AMPylation of heat shock protein 70 (HSP70) family of chaperones participates in altering the aggregation properties and maintaining protein homeostasis (proteostasis), th...Truttmann MC et al.[1] recently reported that AMPylation of heat shock protein 70 (HSP70) family of chaperones participates in altering the aggregation properties and maintaining protein homeostasis (proteostasis), thereby playing a vital role in the development of neurodegenerative diseases (NDs). NDs are commonly manifested by protein aggregates, which exert harmful effects on proteostasis. Interestingly, it has been observed that AMPylation of heat shock proteins (HSPs) can maintain proteostasis by inhibiting the formation of protein aggregates. As previous studies only indicate that HSPs could regulate proteostasis, such a novel discovery further demonstrates the involvement of HSP70 AMPylation in the regulation of protein aggregation and the maintenance of proteostasis. Therefore, AMPylation can be considered to possess a therapeutic potential to target certain physiological processes related to proteostasis, such as age-related diseases.展开更多
Recently, Prieto-Godino et al.[1] found that the olfactory receptor 75a （Ir75a） gene is a functional pseudo-pseudogene in Drosophila sechellia. For a long time, Ir75a has been regarded as an acetic acid receptor tha...Recently, Prieto-Godino et al.[1] found that the olfactory receptor 75a （Ir75a） gene is a functional pseudo-pseudogene in Drosophila sechellia. For a long time, Ir75a has been regarded as an acetic acid receptor that detects acetic acid and induces obvious olfactory responses in olfactory sensory neurons （OSNs）f2J. Nonetheless, Prieto-Godino et al. confirmed that Ir75a lost its sensitivity to acetic acid in D. sechellia. Thus, the D. sechelfia Ir75a gene is generally recognized as a pseudogene in OSNs.展开更多
Mammalian adipose tissues can be broadly divided into white adipose tissue(WAT),beige adipose tissue,and brown adipose tissue(BAT)[1].The function of WAT is to store superfluous energy and is characterized by unilamel...Mammalian adipose tissues can be broadly divided into white adipose tissue(WAT),beige adipose tissue,and brown adipose tissue(BAT)[1].The function of WAT is to store superfluous energy and is characterized by unilamellar lipid droplets.WAT,as a prominent endocrine organ,regulates feeding and satiety by producing hormones.展开更多
基金supported by the grants from the National Natural Science Foundation of China [81470434]
文摘Truttmann MC et al.[1] recently reported that AMPylation of heat shock protein 70 (HSP70) family of chaperones participates in altering the aggregation properties and maintaining protein homeostasis (proteostasis), thereby playing a vital role in the development of neurodegenerative diseases (NDs). NDs are commonly manifested by protein aggregates, which exert harmful effects on proteostasis. Interestingly, it has been observed that AMPylation of heat shock proteins (HSPs) can maintain proteostasis by inhibiting the formation of protein aggregates. As previous studies only indicate that HSPs could regulate proteostasis, such a novel discovery further demonstrates the involvement of HSP70 AMPylation in the regulation of protein aggregation and the maintenance of proteostasis. Therefore, AMPylation can be considered to possess a therapeutic potential to target certain physiological processes related to proteostasis, such as age-related diseases.
基金funded by grants from the National Natural Science Foundation of China[81470434,81503074,81670265]Hunan Province Cooperative Innovation Center for Molecular Target New Drugs Study(Hunan Provincial Education Department document)[Approval number:2014-405]
文摘Recently, Prieto-Godino et al.[1] found that the olfactory receptor 75a （Ir75a） gene is a functional pseudo-pseudogene in Drosophila sechellia. For a long time, Ir75a has been regarded as an acetic acid receptor that detects acetic acid and induces obvious olfactory responses in olfactory sensory neurons （OSNs）f2J. Nonetheless, Prieto-Godino et al. confirmed that Ir75a lost its sensitivity to acetic acid in D. sechellia. Thus, the D. sechelfia Ir75a gene is generally recognized as a pseudogene in OSNs.
基金the grants from the National Natural Science Foundation of China[No.81903615]Natural Science Foundation of Hunan Province[No.2018JJ2339,2018JJ6122]。
文摘Mammalian adipose tissues can be broadly divided into white adipose tissue(WAT),beige adipose tissue,and brown adipose tissue(BAT)[1].The function of WAT is to store superfluous energy and is characterized by unilamellar lipid droplets.WAT,as a prominent endocrine organ,regulates feeding and satiety by producing hormones.
