目的探讨医护一体化管理在瘢痕子宫再次妊娠产妇经阴道分娩中的应用效果。方法将瘢痕子宫再次妊娠产妇230例随机分为对照组和观察组,每组115例。对照组给予常规护理,观察组在此基础上进行医护一体化管理,比较两组分娩结局、产程临床指...目的探讨医护一体化管理在瘢痕子宫再次妊娠产妇经阴道分娩中的应用效果。方法将瘢痕子宫再次妊娠产妇230例随机分为对照组和观察组,每组115例。对照组给予常规护理,观察组在此基础上进行医护一体化管理,比较两组分娩结局、产程临床指标、新生儿体质量和出生1 min Apgar评分、胎儿并发症发生情况及两组产妇对医护人员的满意度、医护人员对诊疗的满意度。结果观察组阴道分娩率高于对照组,出血量少于对照组,总产程短于对照组(均P<0.05);观察组产妇分娩前体质量及新生儿体质量均高于对照组(P<0.05),两组新生儿出生1 min Apgar评分比较差异无统计学意义(P>0.05);观察组产妇、胎儿及新生儿并发症发生率低于对照组(P<0.05);观察组产妇对医护人员满意度、医护人员对诊疗满意度高于对照组(P<0.05)。结论医护一体化管理有助于提高瘢痕子宫再次妊娠产妇经阴道分娩的成功率,降低产妇及新生儿并发症的发生率。展开更多
Background Estrogen deficiency results in loss of bone mass compounds with estrogen-like activity that bind to estrogen receptors effect of the phytoestrogen puerarin on adult mouse osteoblasts. Methods Osteoblast cel...Background Estrogen deficiency results in loss of bone mass compounds with estrogen-like activity that bind to estrogen receptors effect of the phytoestrogen puerarin on adult mouse osteoblasts. Methods Osteoblast cells were harvested from 8-month old female Phytoestrogens are plant-derived non-steroidal The main aim of this study was to investigate the mprinting control region （ICR） mice. The effects of puerarin stimulation on the proliferation, differentiation and maturation of osteoblasts were examined. The production of nitric oxide （NO） and the expression of bone morphogenetic protein-2 （BMP-2）, SMAD4, mitogen-activated protein kinases （MAPK）, core binding factor all runt-related transcription factor 2 （Cbfal/Runx2）, osteoprotegerin （OPG）, and receptor activator of NF-KB ligand （RANKL） genes were analyzed. The activation of signal pathways was further confirmed by specific pathway inhibitors. Results The osteoblast viability reached its maximum at 10-8 mol/L puerarin. At this concentration, puerarin increases the proliferation and matrix mineralization of osteoblasts and promotes NO synthesis. With 108 mol/L puerarin treatment, BMP-2, SMAD4, Cbfal/Runx2, and OPG gene expression were up-regulated, while the RANKL gene expression is down-regulated. Concurrent treatment involving the （bone morphogenetic protein） BMP antagonist Noggin or the NOS inhibitor L-NAME diminishes puerarin induced cell proliferation, Alkaline phosphatase （ALP） activity, NO production, as well as the BMP-2, SMAD4, Cbfal/Runx2, OPG, and RANKL gene expression. Conclusions In this in vitro study, we demonstrate that puerarin is a bone anabolic agent that exerts its osteogenic effects through the induction of BMP-2 and NO synthesis, subsequently regulating Cbfal/Runx2, OPG, and RANKL gene expression. This effect may contribute to its induction of osteoblast proliferation and differentiation, resulting in bone formation.展开更多
文摘目的探讨医护一体化管理在瘢痕子宫再次妊娠产妇经阴道分娩中的应用效果。方法将瘢痕子宫再次妊娠产妇230例随机分为对照组和观察组,每组115例。对照组给予常规护理,观察组在此基础上进行医护一体化管理,比较两组分娩结局、产程临床指标、新生儿体质量和出生1 min Apgar评分、胎儿并发症发生情况及两组产妇对医护人员的满意度、医护人员对诊疗的满意度。结果观察组阴道分娩率高于对照组,出血量少于对照组,总产程短于对照组(均P<0.05);观察组产妇分娩前体质量及新生儿体质量均高于对照组(P<0.05),两组新生儿出生1 min Apgar评分比较差异无统计学意义(P>0.05);观察组产妇、胎儿及新生儿并发症发生率低于对照组(P<0.05);观察组产妇对医护人员满意度、医护人员对诊疗满意度高于对照组(P<0.05)。结论医护一体化管理有助于提高瘢痕子宫再次妊娠产妇经阴道分娩的成功率,降低产妇及新生儿并发症的发生率。
文摘Background Estrogen deficiency results in loss of bone mass compounds with estrogen-like activity that bind to estrogen receptors effect of the phytoestrogen puerarin on adult mouse osteoblasts. Methods Osteoblast cells were harvested from 8-month old female Phytoestrogens are plant-derived non-steroidal The main aim of this study was to investigate the mprinting control region （ICR） mice. The effects of puerarin stimulation on the proliferation, differentiation and maturation of osteoblasts were examined. The production of nitric oxide （NO） and the expression of bone morphogenetic protein-2 （BMP-2）, SMAD4, mitogen-activated protein kinases （MAPK）, core binding factor all runt-related transcription factor 2 （Cbfal/Runx2）, osteoprotegerin （OPG）, and receptor activator of NF-KB ligand （RANKL） genes were analyzed. The activation of signal pathways was further confirmed by specific pathway inhibitors. Results The osteoblast viability reached its maximum at 10-8 mol/L puerarin. At this concentration, puerarin increases the proliferation and matrix mineralization of osteoblasts and promotes NO synthesis. With 108 mol/L puerarin treatment, BMP-2, SMAD4, Cbfal/Runx2, and OPG gene expression were up-regulated, while the RANKL gene expression is down-regulated. Concurrent treatment involving the （bone morphogenetic protein） BMP antagonist Noggin or the NOS inhibitor L-NAME diminishes puerarin induced cell proliferation, Alkaline phosphatase （ALP） activity, NO production, as well as the BMP-2, SMAD4, Cbfal/Runx2, OPG, and RANKL gene expression. Conclusions In this in vitro study, we demonstrate that puerarin is a bone anabolic agent that exerts its osteogenic effects through the induction of BMP-2 and NO synthesis, subsequently regulating Cbfal/Runx2, OPG, and RANKL gene expression. This effect may contribute to its induction of osteoblast proliferation and differentiation, resulting in bone formation.
