目的本研究旨在探讨芒柄花黄素(formononetin,FN)通过干预ROS的生成抑制线粒体动力相关蛋白1(dynamic-related protein 1,DRP1)-NLRP3轴减轻过敏性气道炎症的有关机制。方法为建立过敏性哮喘小鼠模型,50只8周龄的BALB/c小鼠通过卵清蛋白...目的本研究旨在探讨芒柄花黄素(formononetin,FN)通过干预ROS的生成抑制线粒体动力相关蛋白1(dynamic-related protein 1,DRP1)-NLRP3轴减轻过敏性气道炎症的有关机制。方法为建立过敏性哮喘小鼠模型,50只8周龄的BALB/c小鼠通过卵清蛋白(ovalbumin,OVA)诱导后分为对照组、模型组、FN治疗组及地塞米松组。采用HE和Masson染色检测气道炎症和胶原沉积,ELISA测定支气管肺泡灌洗液(BALF)中Th2型细胞因子和超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、丙二醛(MDA)以及IgE水平,DCFH-DA染色评估BEAS-2B细胞中ROS,免疫组织化学和免疫荧光检测肺组织和BEAS-2B细胞中DRP1表达,免疫印迹分析DRP1-NLRP3途径。结果FN治疗可有效改善哮喘小鼠模型的症状,包括减少嗜酸性粒细胞聚集、气道胶原沉积,降低Th2细胞因子和IgE水平,减少ROS和MDA生成,提高SOD和CAT活性,并调节DRP1-NLRP3途径相关蛋白表达,从而缓解炎症。结论FN通过调节DRP1-NLRP3途径改善哮喘气道炎症。展开更多
The digital economy,as a new emerging economic form,has become an important power for realizing Chinese-style modernization and promoting green development in China.This paper measures the digital economy and low-carb...The digital economy,as a new emerging economic form,has become an important power for realizing Chinese-style modernization and promoting green development in China.This paper measures the digital economy and low-carbon transition index based on the data of 30 provinces in China from 2013 to 2020 and analyzes the mechanism and path of the digital economy affecting low-carbon transition using the fixed effect panel data model and the threshold effect model.It is found that,(1)The digital economy and low-carbon transition in China are various in different regions,with characteristics of being unbalanced and insufficient.(2)The digital economy significantly promotes low-carbon transition,with the greatest influence in the Central region,followed by the Eastern region and the Western region.Under different dimensions,the development of informatization and digital transactions promote low-carbon transition,but the development of the internet plays an inhibiting role.(3)The higher the degree of urbanization and environmental regulation,the greater the influence of the digital economy on low-carbon transition.展开更多
Machine learning(ML)domain specific architectures(DSA)and chips have been prevailed in the past few years.These custom DSA designs outperform conventional general purposed architectures in terms of energy efficiency,p...Machine learning(ML)domain specific architectures(DSA)and chips have been prevailed in the past few years.These custom DSA designs outperform conventional general purposed architectures in terms of energy efficiency,processing latency and performance scalability.The data intensive nature of ML requires large amounts of processing power and memory access.Data flow architectures.展开更多
文摘目的本研究旨在探讨芒柄花黄素(formononetin,FN)通过干预ROS的生成抑制线粒体动力相关蛋白1(dynamic-related protein 1,DRP1)-NLRP3轴减轻过敏性气道炎症的有关机制。方法为建立过敏性哮喘小鼠模型,50只8周龄的BALB/c小鼠通过卵清蛋白(ovalbumin,OVA)诱导后分为对照组、模型组、FN治疗组及地塞米松组。采用HE和Masson染色检测气道炎症和胶原沉积,ELISA测定支气管肺泡灌洗液(BALF)中Th2型细胞因子和超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、丙二醛(MDA)以及IgE水平,DCFH-DA染色评估BEAS-2B细胞中ROS,免疫组织化学和免疫荧光检测肺组织和BEAS-2B细胞中DRP1表达,免疫印迹分析DRP1-NLRP3途径。结果FN治疗可有效改善哮喘小鼠模型的症状,包括减少嗜酸性粒细胞聚集、气道胶原沉积,降低Th2细胞因子和IgE水平,减少ROS和MDA生成,提高SOD和CAT活性,并调节DRP1-NLRP3途径相关蛋白表达,从而缓解炎症。结论FN通过调节DRP1-NLRP3途径改善哮喘气道炎症。
基金supported by the Fund of Fujian Provincial Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era(Grant No.FJ2023XZB057)Major Project Fund of Fujian Provincial Social Science Research Base(Grant No.FJ2023JDZ021).
文摘The digital economy,as a new emerging economic form,has become an important power for realizing Chinese-style modernization and promoting green development in China.This paper measures the digital economy and low-carbon transition index based on the data of 30 provinces in China from 2013 to 2020 and analyzes the mechanism and path of the digital economy affecting low-carbon transition using the fixed effect panel data model and the threshold effect model.It is found that,(1)The digital economy and low-carbon transition in China are various in different regions,with characteristics of being unbalanced and insufficient.(2)The digital economy significantly promotes low-carbon transition,with the greatest influence in the Central region,followed by the Eastern region and the Western region.Under different dimensions,the development of informatization and digital transactions promote low-carbon transition,but the development of the internet plays an inhibiting role.(3)The higher the degree of urbanization and environmental regulation,the greater the influence of the digital economy on low-carbon transition.
基金supported by the National Key Research and Development Program of China(No.2022YFB4500100)。
文摘Machine learning(ML)domain specific architectures(DSA)and chips have been prevailed in the past few years.These custom DSA designs outperform conventional general purposed architectures in terms of energy efficiency,processing latency and performance scalability.The data intensive nature of ML requires large amounts of processing power and memory access.Data flow architectures.
