细针穿刺BRAF单基因检测在甲状腺微小乳头状癌中的诊断价值

目的探讨术前细针穿刺BRAF基因检测在甲状腺微小乳头状癌中的临床价值。方法回顾性分析厦门大学附属中山医院普通外科2017年4月—2018年12月共328例甲状腺结节手术患者临床资料。其中<1 cm结节153例患者,≥1 cm甲状腺结节175例患者,根据手术后组织病理学结果,观察两组细针穿刺细胞学结果及BARF基因突变表达情况。计算细针穿刺细胞学、BRAF基因突变和两者联合诊断的敏感性、特异性及准确性,组间比较采用McNemar配对资料2检验。结果以结节直径分为两组,<1 cm结节组中,FNAC在判断结节良恶性的灵敏度、特异度、阳性预测值、阴性预测值、准确率分别是88.2%、95.2%、99.2%、54.1%、89.1%;BRAF基因突变检测在判断结节良恶性的灵敏度、特异度、阳性预测值、阴性预测值、准确率分别是91.0%、100.0%、100.0%、61.8%、92.1%;≥1 cm结节组中,FNAC在判断结节良恶性的灵敏度、特异度、阳性预测值、阴性预测值、准确率分别是88.8%、100.0%、100.0%、78.1%、94.3%;BRAF基因突变检测在判断结节良恶性的灵敏度、特异度、阳性预测值、阴性预测值、准确率分别是77.6%、98.0%、99.0%、63.6%、83.4%。结论单基因检测BRAF突变在<1 cm结节中比FNAC有更好的诊断能力,是甲状腺微小乳头状癌一个可靠的诊断指标。

Heteroepitaxial Growth of Single-Crystalline Diamond Film

Using high temperature heteroepitaxial growth method the single-crystalline diamond film growth conditions have been studied by Raman spectrum and transmission electron diffraction.High temperature,low alcohol concentration,slow gas flow velocity,long epitaxial time and substrate located near the gas exit side on the susceptor are the favourable conditions for growing single-crystalline diamond film.

Experimental Evidences of Nearly Single-Crystalline Diamond Film

The experimental evidences of a nearly single-crystalline diamond film,which was prepared by high temperature heteroepitaxial growth method,have been shown by scanning electron microscopy,transmission electron diffraction and x-ray double crystal diffraction methods.

CT local reconstruction of solid rocket motor based on PI-POCS-TVM

In order to test the defects of solid rocket motor(SRM)accurately and efficiently,the computed tomography(CT)inspection scheme for SRM's defects was investigated and a CT local reconstruction algorithm called prior information-projection onto convex sets-total variation minimization(PI-POCS-TVM)was developed.The SRM was first inspected by industrial CT(ICT)to generate a low-resolution SRM image used as the prior information,then high-resolution local inspection was carried out for SRM's defects.To validate the effectiveness of the CT inspection scheme for SRM's defects,one SRM was inspected by a narrow fan beam ICT system.Filtered back projection(FBP)algorithm,POCS,POCS-TVM and PI-POCS-TVM algorithms were applied to reconstruct CT images.The performance of these algorithms was also compared.Results demonstrated the effectiveness of the CT inspection scheme for SRM's defects.Moreover,the PI-POCS-TVM algorithm has better local reconstruction image quality than the other three algorithms,showing great significance for accurate measurement of SRM's defects.