In this study,different influence mechanisms associated with temperatures and pH values were investigated through cemented paste backfill(CPB)systems.CPB samples were prepared with temperatures ranging from 10 to 50℃...In this study,different influence mechanisms associated with temperatures and pH values were investigated through cemented paste backfill(CPB)systems.CPB samples were prepared with temperatures ranging from 10 to 50℃ in 10℃ increments and pH values of 3,7,and 13.Then,the CPB mixture were subjected to rheological tests,thermogravimetric analysis(TG),derivative thermogravimetry analysis(DTG),Fourier-transform infrared spectroscopy(FT-IR),and scanning electron microscopy(SEM).Results demonstrated that the temperatures had significant effects on the rheological properties of CPB,whereas the effects of pH values were relatively unapparent.Higher temperatures(over 20℃)were prone to bring higher shear stress,yield stress,and apparent viscosity with the same pH value condition.However,an overly high temperature(50℃)cannot raise the apparent viscosity.Non-neutral conditions,for pH values of 3 and 13,could strengthen the shear stress and apparent viscosity at the same temperature.Two different yield stress curves could be discovered by uprising pH values,which also led to apparent viscosity of two various curves under the same temperatures(under 50℃).Microscopically,rheological properties of CPB were affected by temperatures and pH values which enhanced or reduced the cement hydration procedures,rates,products and space structures.展开更多
目的 PET/CT是广泛应用于淋巴瘤疗效评价及预后评估的影像学技术,国际协作项目标准(international harmonization project criteria,IHPC)以及Deauville标准是基于视觉分析PET/CT图像的疗效评价标准。本研究旨在比较上述标准对于治疗结...目的 PET/CT是广泛应用于淋巴瘤疗效评价及预后评估的影像学技术,国际协作项目标准(international harmonization project criteria,IHPC)以及Deauville标准是基于视觉分析PET/CT图像的疗效评价标准。本研究旨在比较上述标准对于治疗结束后霍奇金淋巴瘤(Hodgkin lymphoma,HL)和非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)的疗效评价及预后评估价值,并进一步探讨治疗结束后完全缓解的弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)患者的预后影响因素。方法回顾性分析2010-01-28-2016-10-31天津医科大学总医院PET/CT中心行PET/CT检查、资料完整并确诊为淋巴瘤的70例患者临床资料,其中HL 23例,NHL 47例。所有患者化疗前及化疗结束后均行PET/CT显像,治疗结束后PET(end of treatment PET,ePET)/CT图像分别采用IHPC及Deauville标准进行评估,比较两者的疗效评价效能及预后评估价值。采用Kaplan-Meier生存分析法,进一步分析治疗结束后获得完全缓解的DLBCL患者的预后。结果 IHPC敏感性(sensitiveness,Se)为95.0%,特异性(specificity,Sp)为77.5%,阳性预测值(positive predictive value,PPV)为61.3%,阴性预测值(negative predictive value,NPV)为97.4%,准确性为81.4%,曲线下面积(area under the curve,AUC)为0.818。Deauville标准的Se为85.0%,Sp为88.0%,PPV为73.9%,NPV为93.6%,准确性为87.1%,AUC为0.933,两者AUC差异有统计学意义,Z=2.082,P=0.037。单因素Cox回归分析结果显示,性别、临床分期、IHPC和Deauville标准为HL以及NHL患者预后的有意义因素;多因素回归分析结果显示,IHPC以及Deauville标准为独立预后因素,IHPC的风险比(hazard ratios,HR)为6.61(95%CI:1.85~23.69,P=0.004),Deauville标准HR=9.14(95%CI:2.86~29.20,P<0.001)。完全缓解(complete response,CR)的DLBCL患者预后分析结果显示,Deauville标准评价为阴性的27例DLBCL患者中,组织学类型为生发中心(germinal center B cell,GCB)患者预后优于非生发中心(non-germinal centre B cells,non-GCB),两组生存比较差异有统计学意义,χ2=9.954,P=0.02。结论对于不同类型的HL和NHL,IHPC与Deauville标准均具有疗效评价以及预后评估价值,Deauville标准在一定程度上优于IHPC。治疗结束后完全缓解的DLBCL患者中组织学类型为non-GCB亚型的患者预后不良。展开更多
基金Project(2019zzts678)supported by the Fundamental Research Funds for the Central Universities,China。
文摘In this study,different influence mechanisms associated with temperatures and pH values were investigated through cemented paste backfill(CPB)systems.CPB samples were prepared with temperatures ranging from 10 to 50℃ in 10℃ increments and pH values of 3,7,and 13.Then,the CPB mixture were subjected to rheological tests,thermogravimetric analysis(TG),derivative thermogravimetry analysis(DTG),Fourier-transform infrared spectroscopy(FT-IR),and scanning electron microscopy(SEM).Results demonstrated that the temperatures had significant effects on the rheological properties of CPB,whereas the effects of pH values were relatively unapparent.Higher temperatures(over 20℃)were prone to bring higher shear stress,yield stress,and apparent viscosity with the same pH value condition.However,an overly high temperature(50℃)cannot raise the apparent viscosity.Non-neutral conditions,for pH values of 3 and 13,could strengthen the shear stress and apparent viscosity at the same temperature.Two different yield stress curves could be discovered by uprising pH values,which also led to apparent viscosity of two various curves under the same temperatures(under 50℃).Microscopically,rheological properties of CPB were affected by temperatures and pH values which enhanced or reduced the cement hydration procedures,rates,products and space structures.
文摘目的 PET/CT是广泛应用于淋巴瘤疗效评价及预后评估的影像学技术,国际协作项目标准(international harmonization project criteria,IHPC)以及Deauville标准是基于视觉分析PET/CT图像的疗效评价标准。本研究旨在比较上述标准对于治疗结束后霍奇金淋巴瘤(Hodgkin lymphoma,HL)和非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)的疗效评价及预后评估价值,并进一步探讨治疗结束后完全缓解的弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)患者的预后影响因素。方法回顾性分析2010-01-28-2016-10-31天津医科大学总医院PET/CT中心行PET/CT检查、资料完整并确诊为淋巴瘤的70例患者临床资料,其中HL 23例,NHL 47例。所有患者化疗前及化疗结束后均行PET/CT显像,治疗结束后PET(end of treatment PET,ePET)/CT图像分别采用IHPC及Deauville标准进行评估,比较两者的疗效评价效能及预后评估价值。采用Kaplan-Meier生存分析法,进一步分析治疗结束后获得完全缓解的DLBCL患者的预后。结果 IHPC敏感性(sensitiveness,Se)为95.0%,特异性(specificity,Sp)为77.5%,阳性预测值(positive predictive value,PPV)为61.3%,阴性预测值(negative predictive value,NPV)为97.4%,准确性为81.4%,曲线下面积(area under the curve,AUC)为0.818。Deauville标准的Se为85.0%,Sp为88.0%,PPV为73.9%,NPV为93.6%,准确性为87.1%,AUC为0.933,两者AUC差异有统计学意义,Z=2.082,P=0.037。单因素Cox回归分析结果显示,性别、临床分期、IHPC和Deauville标准为HL以及NHL患者预后的有意义因素;多因素回归分析结果显示,IHPC以及Deauville标准为独立预后因素,IHPC的风险比(hazard ratios,HR)为6.61(95%CI:1.85~23.69,P=0.004),Deauville标准HR=9.14(95%CI:2.86~29.20,P<0.001)。完全缓解(complete response,CR)的DLBCL患者预后分析结果显示,Deauville标准评价为阴性的27例DLBCL患者中,组织学类型为生发中心(germinal center B cell,GCB)患者预后优于非生发中心(non-germinal centre B cells,non-GCB),两组生存比较差异有统计学意义,χ2=9.954,P=0.02。结论对于不同类型的HL和NHL,IHPC与Deauville标准均具有疗效评价以及预后评估价值,Deauville标准在一定程度上优于IHPC。治疗结束后完全缓解的DLBCL患者中组织学类型为non-GCB亚型的患者预后不良。
