目的探讨微波治疗术联合派特灵对尖锐湿疣患者外周血自然杀伤T细胞及相关细胞因子的影响。方法共128例尖锐湿疣患者,均为2018年1月-2019年6月期间在本院治疗患者,按照随机数表法分为对照组和研究组,各64例,对照组患者采用微波治疗术治疗...目的探讨微波治疗术联合派特灵对尖锐湿疣患者外周血自然杀伤T细胞及相关细胞因子的影响。方法共128例尖锐湿疣患者,均为2018年1月-2019年6月期间在本院治疗患者,按照随机数表法分为对照组和研究组,各64例,对照组患者采用微波治疗术治疗,研究组在对照组基础上使用派特灵治疗,观察记录两组患者治疗后3、6、9个月复发例数,并计算复发率,使用流式细胞仪检测患者细胞免疫学指标CD8^(+)、CD4^(+)、CD3^(+)、自然杀伤T细胞(natural killer T cell,NTK)水平,并计算CD4^(+)/CD8^(+)值,其中以NTK占淋巴细胞数目的比值进行分析,观察治疗前后患者CD8^(+)T细胞、CD4^(+)T细胞内白细胞介素-2(Interleukin-2,IL-2)、白细胞介素-4(Interleukin-4,IL-4)、白细胞介素-12(Interleukin-12,IL-12)及γ干扰素(IFN-γ)染色阳性细胞百分率,记录两组治疗效果。结果研究组患者治疗3个月后复发率为1.56%,治疗6个月后复发率为6.25%,治疗9个月后复发率为7.81%,低于对照组的14.06%、23.44%和35.94%,差异有统计学意义(P<0.05);治疗前,两组患者CD4^(+)/CD8^(+)、CD8^(+)、CD4^(+)、CD3^(+)和NTK差异无统计学意义(P>0.05),治疗后,两组患者CD4^(+)/CD8^(+)、CD8^(+)、CD4^(+)、CD3^(+)和NTK均升高,且研究组患者CD4^(+)/CD8^(+)、CD8^(+)、CD4^(+)、CD3^(+)和NTK均高于对照组,差异有统计学意义(P<0.05);治疗前,两组患者CD8^(+)T细胞、CD4^(+)T细胞中细胞因子IFN-γ、IL-12、IL-4和IL-2染色阳性细胞百分率差异无统计学意义(P>0.05),经过治疗,两组患者CD8^(+)T细胞、CD4^(+)T细胞中细胞因子IFN-γ、IL-12、IL-4和IL-2染色阳性细胞百分率均升高,且研究组患者均大于对照组,差异有统计学意义(P<0.05);研究组患者总有效率96.87%,高于对照组的79.69%,差异有统计学意义(P<0.05)。结论微波治疗术联合派特灵可降低尖锐湿疣患者复发率,提高患者外周血自然杀伤T细胞及相关细胞因子水平,增强免疫能力,提高治疗效果。展开更多
Tectonic and environmental patterns and evolution of the present North Tibetan Plateau （NTP） prior to the India collision with Asia is significant to understand the formation of the Tibetan Plateau and its influence...Tectonic and environmental patterns and evolution of the present North Tibetan Plateau （NTP） prior to the India collision with Asia is significant to understand the formation of the Tibetan Plateau and its influence on the environment.In this study,we integrated and analyzed the tectonostratigraphy and the special sedimentary layers whose climatic implications are clear in the NTP.Additionally,we stressed the tectonic and environmental events and their evolutions from the Mesozoic to the Early Cenozoic.Our results show that four tectonic phases,which sequentially took place during the Triassic,Jurassic,Cretaceous and Paleogene,played an important role on the formation of the North Tibet.The climate was basically dry and hot from the Triassic to the Eocene and became dry and cool since the Oligocene in this region.The climatic evolution was characterized by a transition from a wet and hot phase during the Triassic-Middle Jurassic,to a dry and hot phase during the Late Jurassic-Eocene.Both phases encompassed 5 wet and hot periods followed by 5 dry and hot climate events,respectively.In addition,we found that the tectonic deformation and the climatic conditions were spatially and temporally different.In detail,in the regions north of the PaleoTian Shan and Paleo-Qilian Mts.the tectonic deformation and climatic condition were stronger and wetter than in regions south of the Paleo-Tian Shan and Paleo-Qilian Mts.during the Late Triassic-Jurassic.Whereas in the Cretaceous,the tectonic movement was intensive in the west but steady in the east,and climate was dry in the south but wet in the north of NTP.The formation of the tectonic and climatic patterns in NTP were the consequence of either global climate change or regional tectonics,including the Paleo-Asian Ocean closure and the Qiangtang block,Lhasa block and India plate collision subsequently to Asia.Furthermore,the regional tectonic events occurred before any global climate change and drove the climatic change in the NTP.展开更多
文摘目的探讨微波治疗术联合派特灵对尖锐湿疣患者外周血自然杀伤T细胞及相关细胞因子的影响。方法共128例尖锐湿疣患者,均为2018年1月-2019年6月期间在本院治疗患者,按照随机数表法分为对照组和研究组,各64例,对照组患者采用微波治疗术治疗,研究组在对照组基础上使用派特灵治疗,观察记录两组患者治疗后3、6、9个月复发例数,并计算复发率,使用流式细胞仪检测患者细胞免疫学指标CD8^(+)、CD4^(+)、CD3^(+)、自然杀伤T细胞(natural killer T cell,NTK)水平,并计算CD4^(+)/CD8^(+)值,其中以NTK占淋巴细胞数目的比值进行分析,观察治疗前后患者CD8^(+)T细胞、CD4^(+)T细胞内白细胞介素-2(Interleukin-2,IL-2)、白细胞介素-4(Interleukin-4,IL-4)、白细胞介素-12(Interleukin-12,IL-12)及γ干扰素(IFN-γ)染色阳性细胞百分率,记录两组治疗效果。结果研究组患者治疗3个月后复发率为1.56%,治疗6个月后复发率为6.25%,治疗9个月后复发率为7.81%,低于对照组的14.06%、23.44%和35.94%,差异有统计学意义(P<0.05);治疗前,两组患者CD4^(+)/CD8^(+)、CD8^(+)、CD4^(+)、CD3^(+)和NTK差异无统计学意义(P>0.05),治疗后,两组患者CD4^(+)/CD8^(+)、CD8^(+)、CD4^(+)、CD3^(+)和NTK均升高,且研究组患者CD4^(+)/CD8^(+)、CD8^(+)、CD4^(+)、CD3^(+)和NTK均高于对照组,差异有统计学意义(P<0.05);治疗前,两组患者CD8^(+)T细胞、CD4^(+)T细胞中细胞因子IFN-γ、IL-12、IL-4和IL-2染色阳性细胞百分率差异无统计学意义(P>0.05),经过治疗,两组患者CD8^(+)T细胞、CD4^(+)T细胞中细胞因子IFN-γ、IL-12、IL-4和IL-2染色阳性细胞百分率均升高,且研究组患者均大于对照组,差异有统计学意义(P<0.05);研究组患者总有效率96.87%,高于对照组的79.69%,差异有统计学意义(P<0.05)。结论微波治疗术联合派特灵可降低尖锐湿疣患者复发率,提高患者外周血自然杀伤T细胞及相关细胞因子水平,增强免疫能力,提高治疗效果。
基金supported by the Chinese NSFC funds (Nos. 41272127, 41330745, 41021091)
文摘Tectonic and environmental patterns and evolution of the present North Tibetan Plateau （NTP） prior to the India collision with Asia is significant to understand the formation of the Tibetan Plateau and its influence on the environment.In this study,we integrated and analyzed the tectonostratigraphy and the special sedimentary layers whose climatic implications are clear in the NTP.Additionally,we stressed the tectonic and environmental events and their evolutions from the Mesozoic to the Early Cenozoic.Our results show that four tectonic phases,which sequentially took place during the Triassic,Jurassic,Cretaceous and Paleogene,played an important role on the formation of the North Tibet.The climate was basically dry and hot from the Triassic to the Eocene and became dry and cool since the Oligocene in this region.The climatic evolution was characterized by a transition from a wet and hot phase during the Triassic-Middle Jurassic,to a dry and hot phase during the Late Jurassic-Eocene.Both phases encompassed 5 wet and hot periods followed by 5 dry and hot climate events,respectively.In addition,we found that the tectonic deformation and the climatic conditions were spatially and temporally different.In detail,in the regions north of the PaleoTian Shan and Paleo-Qilian Mts.the tectonic deformation and climatic condition were stronger and wetter than in regions south of the Paleo-Tian Shan and Paleo-Qilian Mts.during the Late Triassic-Jurassic.Whereas in the Cretaceous,the tectonic movement was intensive in the west but steady in the east,and climate was dry in the south but wet in the north of NTP.The formation of the tectonic and climatic patterns in NTP were the consequence of either global climate change or regional tectonics,including the Paleo-Asian Ocean closure and the Qiangtang block,Lhasa block and India plate collision subsequently to Asia.Furthermore,the regional tectonic events occurred before any global climate change and drove the climatic change in the NTP.
