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脂质代谢在哮喘中作用机制的研究进展
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作者 陈少甜(综述) 杨男(审校) 《临床儿科杂志》 CAS CSCD 北大核心 2024年第5期461-466,共6页
哮喘是最常见的慢性呼吸系统疾病之一,累及全年龄段,其患病率与社会医疗费用逐年升高。近年来大量研究证实,脂质分子作为调节多种细胞生物过程强有力的信号分子,通过对哮喘患者气道不同细胞的调节,影响疾病的发生发展。因此,本文从近年... 哮喘是最常见的慢性呼吸系统疾病之一,累及全年龄段,其患病率与社会医疗费用逐年升高。近年来大量研究证实,脂质分子作为调节多种细胞生物过程强有力的信号分子,通过对哮喘患者气道不同细胞的调节,影响疾病的发生发展。因此,本文从近年来不断发展的脂质组学与哮喘的研究出发,总结哮喘中潜在的代谢生物标志物,探讨脂质代谢在哮喘发病过程对不同细胞发挥的作用机制,为哮喘的个性化治疗提供思路。 展开更多
关键词 哮喘 脂质代谢 脂质组学 脂肪酸 免疫细胞
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Lessons from Coronavirus Disease 2019 Infections in Children
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作者 WU Xiayu chen shaotian +2 位作者 chenG Jiaoni KAN Xiangxu FAN Dongmei 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2020年第6期555-564,共10页
The novel coronavirus disease 2019(COVID-19)in human caused by novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is currently rampant across the world,causing an international concern for public health ... The novel coronavirus disease 2019(COVID-19)in human caused by novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is currently rampant across the world,causing an international concern for public health emergency.At the time of July,2020,about 8380000 confirmed cases and more than 450000 deaths have been reported worldwide.This is the third outbreak of severe coronavirus family after the Middle East respiratory syndrome(MERS)and severe acute respiratory syndrome(SARS).Young victims(<12 years)in clinical course and prognosis of pediatric COVID-19 appear symptomatically milder than do teenage and adult patients,and many children with asymptomatic infections or showing only mild symptoms may be transmitter as well.Thus,the children with COVID-19 infection deserve more attention.This review is cautiously designed to report the clinical characteristics and symptoms of three kinds of coronaviruses(SARS-CoV,MERS-CoV,and SARS-CoV-2)in children and to summarize some recommended tactics to reduce COVID-19 transmission and/or to attain improved prevention in children. 展开更多
关键词 CORONAVIRUS COVID-19 Middle East respiratory syndrome(MERS) SARS CHILDREN recommendations
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