We investigated the size distribution of water-stable aggregates and the soil carbon, nitrogen and phosphorus concentration over aggregate size fractions based on a long-term （1990-2006） fertilization experiment in ...We investigated the size distribution of water-stable aggregates and the soil carbon, nitrogen and phosphorus concentration over aggregate size fractions based on a long-term （1990-2006） fertilization experiment in a reddish paddy soil. The results showed that the largest water-stable aggregate （WSA） （〉5 mm） and the smallest WSA （〈0.25 mm） took up the first largest proportion （38.3%） and the second largest proportion （23.3%）, respectively. Application of organic materials increased the proportion of the large WSA （〉2 mm） and decreased the proportion of the small WSA （〈1 ram）, resulting in an increase in the mean weight diameter of WSA, whereas application of chemical fertilizer had little effect. Application of organic materials, especially combined with chemical fertilizers, increased total carbon, nitrogen and phosphorus concentrations in all sizes of WSA, and total carbon, nitrogen and phosphorus were prone to concentrate in the large WSA. Further more, application of organic materials improved the supply effectiveness of available phosphorus, whereas had little influence on the labile carbon in WSA. Application of chemical fertilizers improved concentrations of total and available phosphorus in all sizes of WSA, whereas had little influence on total carbon and nitrogen contents. Economical fertilization model maintained the soil fertility when compared with full dose of chemical fertilizers, indicating that using organic materials could reduce chemical fertilizers by about one third.展开更多
三阴型乳腺癌(triple negative breast cancer,TNBC)为恶性程度最高、临床预后最差的乳腺癌亚型之一。其高侵袭转移能力是导致TNBC复发转移,改变患者临床预后的关键。基于人类基因组计划的完成,目前已认识到基因组水平并不能完全揭露TNB...三阴型乳腺癌(triple negative breast cancer,TNBC)为恶性程度最高、临床预后最差的乳腺癌亚型之一。其高侵袭转移能力是导致TNBC复发转移,改变患者临床预后的关键。基于人类基因组计划的完成,目前已认识到基因组水平并不能完全揭露TNBC肿瘤细胞各通路的作用机制。蛋白质组学作为新兴的研究手段,可以进行高通量筛选差异性表达蛋白质,完成相关肿瘤细胞恶性行为的功能学研究,探索TNBC高侵袭转移机制,为TNBC的临床诊疗研究提供了技术支持。该文旨在概述蛋白质组学在TNBC侵袭转移机制研究中的应用以及目前所取得的进展。展开更多
基金funded by the Knowledge Innovativation Program of the Chinese Academy of Sciences (KZCX2-YW-423)the National Basic Research Program of China (2005CB121106)
文摘We investigated the size distribution of water-stable aggregates and the soil carbon, nitrogen and phosphorus concentration over aggregate size fractions based on a long-term （1990-2006） fertilization experiment in a reddish paddy soil. The results showed that the largest water-stable aggregate （WSA） （〉5 mm） and the smallest WSA （〈0.25 mm） took up the first largest proportion （38.3%） and the second largest proportion （23.3%）, respectively. Application of organic materials increased the proportion of the large WSA （〉2 mm） and decreased the proportion of the small WSA （〈1 ram）, resulting in an increase in the mean weight diameter of WSA, whereas application of chemical fertilizer had little effect. Application of organic materials, especially combined with chemical fertilizers, increased total carbon, nitrogen and phosphorus concentrations in all sizes of WSA, and total carbon, nitrogen and phosphorus were prone to concentrate in the large WSA. Further more, application of organic materials improved the supply effectiveness of available phosphorus, whereas had little influence on the labile carbon in WSA. Application of chemical fertilizers improved concentrations of total and available phosphorus in all sizes of WSA, whereas had little influence on total carbon and nitrogen contents. Economical fertilization model maintained the soil fertility when compared with full dose of chemical fertilizers, indicating that using organic materials could reduce chemical fertilizers by about one third.
文摘三阴型乳腺癌(triple negative breast cancer,TNBC)为恶性程度最高、临床预后最差的乳腺癌亚型之一。其高侵袭转移能力是导致TNBC复发转移,改变患者临床预后的关键。基于人类基因组计划的完成,目前已认识到基因组水平并不能完全揭露TNBC肿瘤细胞各通路的作用机制。蛋白质组学作为新兴的研究手段,可以进行高通量筛选差异性表达蛋白质,完成相关肿瘤细胞恶性行为的功能学研究,探索TNBC高侵袭转移机制,为TNBC的临床诊疗研究提供了技术支持。该文旨在概述蛋白质组学在TNBC侵袭转移机制研究中的应用以及目前所取得的进展。
