Study on the Size Distribution and Similarity Law of Bubble Nuclei in Water

To study the distribution characteristics and similarity laws of nuclei under different pressures,based on the selfdesigned decompression chamber and the acoustic measuring system,the size distributions of nuclei in the degassed tap water under negative ambient pressures were measured.A number density distribution function of nuclei based on the modified Weibull distribution function was proposed and verified by the experimental measurement results and some published data of nuclei size distribution.Based on this nuclei number density distribution function,the similarity law of the nuclei size distribution was analyzed:in the scale experiment,the value of exponential in the similarity law of the nuclei number density should be determined by the nuclei size distribution of the water in the prototype experiment and the actual nuclei size distribution of the water in the model experiment.And a precondition is that the nuclei size distributions are similar.

磷酸奥司他韦对甲型流感病毒感染患儿淋巴细胞亚群及临床疗效影响

目的通过对比分析磷酸奥司他韦对甲型流感病毒感染患儿淋巴细胞亚群及临床疗效的影响,为治疗甲型流感病毒感染提供理论依据。方法选取2016年1月~2018年1月丽水市中心医院接诊的91例甲型流感病毒感染患儿为研究对象,均按照预防控制要求处理;按照随机数字表法随机分为对照组和研究组,对照组45例,使用病毒唑注射液治疗,研究组46例,在对照组基础上添加磷酸奥司他韦颗粒治疗;观察记录患儿的淋巴细胞亚群表达水平、血细胞表达水平、免疫学指标表达水平、炎症因子表达水平、临床症状改善情况、患儿治疗效果和不良反应发生情况。结果研究组患儿总有效率高达95.65%,显著高于对照组患儿的68.89%,差异有统计学意义(P<0.05);研究组患儿CD3+T细胞、CD4+T细胞、NK细胞和CD8+T细胞均显著高于对照组患儿,差异有统计学意义(P<0.05);研究组患儿白细胞和血小板水平高于对照组患儿,嗜中性粒细胞低于对照组患儿,差异有统计学意义(P<0.05);研究组患儿IgM和IgG高于对照组患儿,补体C4和补体C3低于对照组患儿,差异有统计学意义(P<0.05);研究组患儿IL-6、IL-8、IL-12、IL-18、TNF-α表达水平均低于对照组患儿,差异有统计学意义(P<0.05);研究组患儿病毒核酸转阴时间、乏力缓解时间和发热消退时间均短于对照组患儿,差异有统计学意义(P<0.05)。结论磷酸奥司他韦可明显提高甲型流感病毒感染患儿淋巴细胞亚群比例,降低患儿炎症反应,提高患儿免疫能力,改善患儿临床症状,治疗效果显著。