目的:对中国知网(CNKI)和Web of Science核心合集已发表的国内外糖尿病前期护理相关文献进行可视化分析,了解当前糖尿病前期在护理领域的研究现状、研究热点和发展趋势。方法:采用文献计量学研究方法,检索数据库中自建库至2023年5月1日...目的:对中国知网(CNKI)和Web of Science核心合集已发表的国内外糖尿病前期护理相关文献进行可视化分析,了解当前糖尿病前期在护理领域的研究现状、研究热点和发展趋势。方法:采用文献计量学研究方法,检索数据库中自建库至2023年5月1日以“糖尿病前期”和“护理”为关键词的文献,运用CiteSpace 6.2可视化软件进行分析。结果:国内外发文量呈增长趋势,但总体发文量较少。美国在该领域发文量最多;作者和机构间合作不够紧密。关键词主要以糖尿病前期相关疾病、糖尿病前期健康管理和糖尿病前期干预预防为主。糖尿病前期和健康管理是国内近年来的研究热点,生活方式干预和血糖控制是国外近年来的研究热点。结论:糖尿病前期护理研究领域仍处于上升发展阶段,学者应展开深入研究,探索和构建适应我国国情的糖尿病前期病人的综合健康管理模式。展开更多
OBJECTIVE To assess whether N-acetylcysteine(NAC)and reduced glutathione(GSH)are effective in reversing flupirtine-induced hepatotoxicity and whether they have other beneficial effects when combined with flupirtine.ME...OBJECTIVE To assess whether N-acetylcysteine(NAC)and reduced glutathione(GSH)are effective in reversing flupirtine-induced hepatotoxicity and whether they have other beneficial effects when combined with flupirtine.METHODS The analgesic effects of NAC and flupirtine were first evaluated in carrageenaninduced inflammatory pain and paclitaxel-induced neuropathic pain.The combination subthreshold⁃ing approach was then used to determine whether the combination of NAC and flupirtine produced synergistic analgesic effects.Hepatotoxicity markers and histopathological examination of the liver were used to assess the efficacy of NAC and GSH in reversing flupirtine-induced hepato⁃toxicity.Finally,the effect of GSH on the safe range of flupirtine was assessed in an acute tox⁃icity assay.RESULTS Flupirtine and NAC pro⁃duced dose-dependent antiallodynic effects evoked by carrageenan and paclitaxel in mice.In the above model,the combination of NAC and flupirtine produced an unexpected synergistic analgesic effect.There were no significant differ⁃ences observed in the hepatotoxicity markers and liver histopathology between the experimen⁃tal group and the control group under NAC and GSH treatment.Finally,GSH(200 mg·kg^(-1))expanded the therapeutic index of flupirtine by 1.77 times.CONCLUSION NAC and GSH are effective in preventing liver damage caused by long-term flupirtine use,which provides a solu⁃tion for the safe and effective treatment of chronic pain with flupirtine.In addition,the other benefi⁃cial effects of NAC and GSH when combined with flupirtine may provide the basis for the devel⁃opment of a new therapy with minimal sideeffects and good efficacy.展开更多
文摘目的:对中国知网(CNKI)和Web of Science核心合集已发表的国内外糖尿病前期护理相关文献进行可视化分析,了解当前糖尿病前期在护理领域的研究现状、研究热点和发展趋势。方法:采用文献计量学研究方法,检索数据库中自建库至2023年5月1日以“糖尿病前期”和“护理”为关键词的文献,运用CiteSpace 6.2可视化软件进行分析。结果:国内外发文量呈增长趋势,但总体发文量较少。美国在该领域发文量最多;作者和机构间合作不够紧密。关键词主要以糖尿病前期相关疾病、糖尿病前期健康管理和糖尿病前期干预预防为主。糖尿病前期和健康管理是国内近年来的研究热点,生活方式干预和血糖控制是国外近年来的研究热点。结论:糖尿病前期护理研究领域仍处于上升发展阶段,学者应展开深入研究,探索和构建适应我国国情的糖尿病前期病人的综合健康管理模式。
基金Priority Academic Program Development of Jiangsu Higher Education Institutions(2022JSPAPD006)。
文摘OBJECTIVE To assess whether N-acetylcysteine(NAC)and reduced glutathione(GSH)are effective in reversing flupirtine-induced hepatotoxicity and whether they have other beneficial effects when combined with flupirtine.METHODS The analgesic effects of NAC and flupirtine were first evaluated in carrageenaninduced inflammatory pain and paclitaxel-induced neuropathic pain.The combination subthreshold⁃ing approach was then used to determine whether the combination of NAC and flupirtine produced synergistic analgesic effects.Hepatotoxicity markers and histopathological examination of the liver were used to assess the efficacy of NAC and GSH in reversing flupirtine-induced hepato⁃toxicity.Finally,the effect of GSH on the safe range of flupirtine was assessed in an acute tox⁃icity assay.RESULTS Flupirtine and NAC pro⁃duced dose-dependent antiallodynic effects evoked by carrageenan and paclitaxel in mice.In the above model,the combination of NAC and flupirtine produced an unexpected synergistic analgesic effect.There were no significant differ⁃ences observed in the hepatotoxicity markers and liver histopathology between the experimen⁃tal group and the control group under NAC and GSH treatment.Finally,GSH(200 mg·kg^(-1))expanded the therapeutic index of flupirtine by 1.77 times.CONCLUSION NAC and GSH are effective in preventing liver damage caused by long-term flupirtine use,which provides a solu⁃tion for the safe and effective treatment of chronic pain with flupirtine.In addition,the other benefi⁃cial effects of NAC and GSH when combined with flupirtine may provide the basis for the devel⁃opment of a new therapy with minimal sideeffects and good efficacy.
