Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulatio...Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulation techniques offer accurate manipulation of targeted areas,even selectively modulating specific neurons,in the brain.This makes it possible to investigate the cause-and-effect connections between neural activity and behavior,allowing for a better comprehension of the intricate brain dynamics towards complex environments.Non-human primates serve as an essential animal model for investigating these complex functions in brain research,bridging the gap between the basic research and clinical applications.One of the earliest optical studies utilizing optogenetic neuromodulation in monkeys was conducted in 2009.Since then,the optical-neural stimulations have been effectively applied in non-human primates.This review summarises recent research that employed optogenetics or infrared neurostimulation techniques to regulate brain function and behavior in non-human primates.The current state of optical-neural stimulations discussed here demonstrates their efficacy in advancing the understanding of brain systems.Nevertheless,there are still challenges that need to be addressed before they can fully achieve their potential.展开更多
目的对淫羊藿苷相关的文献数据进行分析,挖掘淫羊藿苷的研究热点和未来研究方向。方法通过R语言和VOSviewer软件对Web of Science数据库核心集中淫羊藿苷的研究性和综述文献进行计量学分析,结果以可视化形式呈现,分析该领域年发文量趋...目的对淫羊藿苷相关的文献数据进行分析,挖掘淫羊藿苷的研究热点和未来研究方向。方法通过R语言和VOSviewer软件对Web of Science数据库核心集中淫羊藿苷的研究性和综述文献进行计量学分析,结果以可视化形式呈现,分析该领域年发文量趋势、国家机构间合作和未来研究热点。结果共检索到1060篇文献,2012—2021年发文量占比81.69%,主要集中在以中国为主的亚洲国家,且各国之间合作密切。机构发文量分析显示复旦大学发文量最多达52篇,接收文章最多的期刊为Molecular Medicine Reports和Molecules,均为28篇。关键词演化分析表明淫羊藿苷的研究主要集中在抗炎、抗氧化、抗凋亡等机制和信号通路方面。随着中医药学和多学科的交叉融合发展,尤其以先进药物递送系统为基础改善淫羊藿苷水溶性差等问题将成为未来热点研究领域。结论淫羊藿苷的年发文量呈递增趋势,主要研究机构分布在国内多个高校和科研院所。以分子生物学技术深入解析淫羊藿苷的药理作用机制,通过化学修饰和制剂学手段改善和提高淫羊藿苷的药效学将为淫羊藿苷的应用提供理论依据和解决方案。对从事淫羊藿苷研究的科研人员具有重要的参考价值。展开更多
基金supported by grants from National Key R&D Program of China(2022YFB4700101)STI2030-Major Projects(2022ZD0204800)The National Natural Science Foundation of China(32070987)。
文摘Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulation techniques offer accurate manipulation of targeted areas,even selectively modulating specific neurons,in the brain.This makes it possible to investigate the cause-and-effect connections between neural activity and behavior,allowing for a better comprehension of the intricate brain dynamics towards complex environments.Non-human primates serve as an essential animal model for investigating these complex functions in brain research,bridging the gap between the basic research and clinical applications.One of the earliest optical studies utilizing optogenetic neuromodulation in monkeys was conducted in 2009.Since then,the optical-neural stimulations have been effectively applied in non-human primates.This review summarises recent research that employed optogenetics or infrared neurostimulation techniques to regulate brain function and behavior in non-human primates.The current state of optical-neural stimulations discussed here demonstrates their efficacy in advancing the understanding of brain systems.Nevertheless,there are still challenges that need to be addressed before they can fully achieve their potential.
文摘目的对淫羊藿苷相关的文献数据进行分析,挖掘淫羊藿苷的研究热点和未来研究方向。方法通过R语言和VOSviewer软件对Web of Science数据库核心集中淫羊藿苷的研究性和综述文献进行计量学分析,结果以可视化形式呈现,分析该领域年发文量趋势、国家机构间合作和未来研究热点。结果共检索到1060篇文献,2012—2021年发文量占比81.69%,主要集中在以中国为主的亚洲国家,且各国之间合作密切。机构发文量分析显示复旦大学发文量最多达52篇,接收文章最多的期刊为Molecular Medicine Reports和Molecules,均为28篇。关键词演化分析表明淫羊藿苷的研究主要集中在抗炎、抗氧化、抗凋亡等机制和信号通路方面。随着中医药学和多学科的交叉融合发展,尤其以先进药物递送系统为基础改善淫羊藿苷水溶性差等问题将成为未来热点研究领域。结论淫羊藿苷的年发文量呈递增趋势,主要研究机构分布在国内多个高校和科研院所。以分子生物学技术深入解析淫羊藿苷的药理作用机制,通过化学修饰和制剂学手段改善和提高淫羊藿苷的药效学将为淫羊藿苷的应用提供理论依据和解决方案。对从事淫羊藿苷研究的科研人员具有重要的参考价值。
