The transmission probability of an ultracold cascade three-level atom through a micromaser cavity is calculated and analyzed. It is shown that the micromaser cavity can be used as a velocity selector for ultracold thr...The transmission probability of an ultracold cascade three-level atom through a micromaser cavity is calculated and analyzed. It is shown that the micromaser cavity can be used as a velocity selector for ultracold three-level atoms, and the velocity selectivity is better for three-level atoms than for two-level atoms.展开更多
[目的]采用HPLC-MS/MS建立检测65%甲基磺草酮·氯氟吡氧乙酸异辛酯·莠去津可湿性粉剂含量的方法。[方法]采用高效液相色谱-串联质谱法,以0.1%甲酸水溶液-乙腈为流动相梯度洗脱,使用以Eclipse Plus C18柱和MSD检测器,对试样中...[目的]采用HPLC-MS/MS建立检测65%甲基磺草酮·氯氟吡氧乙酸异辛酯·莠去津可湿性粉剂含量的方法。[方法]采用高效液相色谱-串联质谱法,以0.1%甲酸水溶液-乙腈为流动相梯度洗脱,使用以Eclipse Plus C18柱和MSD检测器,对试样中的甲基磺草酮、氯氟吡氧乙酸异辛酯和莠去津进行测定,外标法定量。[结果]该分析方法甲基磺草酮、氯氟吡氧乙酸异辛酯和莠去津线性相关系数分别为0.9998、0.9994和0.9998,变异系数分别为0.67%、2.01%和0.29%,平均回收率分别为103.52%、117.74%和115.75%。[结论]该方法的操作简单,精密度、准确度和灵敏度均满足要求,可用于65%甲基磺草酮·氯氟吡氧乙酸异辛酯·莠去津可湿性粉剂含量检测。展开更多
Background A new inhalable insulin aerosol （Inh-lns） was developed in China. The aim of this multicenter clinical study was to evaluate the efficacy and safety of this new Inh-lns as a treatment of type 2 diabetes. ...Background A new inhalable insulin aerosol （Inh-lns） was developed in China. The aim of this multicenter clinical study was to evaluate the efficacy and safety of this new Inh-lns as a treatment of type 2 diabetes. Regular porcine insulin （RI） was used as a control. Methods This study is a prospective, randomized, open-label, parallel-group multicenter clinical trial in which 253 qualified patients with type 2 diabetes received the insulin Glargine daily at bedtime plus either a pre-meal Inh-lns or a pre-meal subcutaneous RI for 12 weeks. HbAlc, fasting plasma glucose （FPG）, the 1-hour-postprandial blood glucose （1hPBG） and the 2-hour-postprandial blood glucose （2hPBG） were measured. Events were monitored for adverse effects. Results After 12 weeks, the HbAlc decreased significantly from baseline in both treatment groups, with no significant difference between the two regimens. In the Inh-lns group, FPG, both lhPBG and 2hPBG significantly declined from baseline after the 8th- and 12th-weeks of treatment. The reduced values of FPG or 1hPBG between the two groups showed a more significant hypoglycemic effect with the Inh-lns than the RI. After 12 weeks, the pulmonary carbon monoxide diffusing capacity （DLco） was significantly lower in Inh-lns group than in the RI. The main side effects of Inh-lns were coughing, excessive sputum, and hypoglycemia. Conclusions Inh-lns was effective in decreasing HbAlc like the RI. It was better in lowering the FPG and the lhPBG than the RI. Its main side effects were coughing, excessive sputum, and hypoglycemia. Also, Inh-lns slightly impaired DLco.展开更多
基金the Senior Visiting Scholor Project of Chinese Academy of Sciences。
文摘The transmission probability of an ultracold cascade three-level atom through a micromaser cavity is calculated and analyzed. It is shown that the micromaser cavity can be used as a velocity selector for ultracold three-level atoms, and the velocity selectivity is better for three-level atoms than for two-level atoms.
文摘[目的]采用HPLC-MS/MS建立检测65%甲基磺草酮·氯氟吡氧乙酸异辛酯·莠去津可湿性粉剂含量的方法。[方法]采用高效液相色谱-串联质谱法,以0.1%甲酸水溶液-乙腈为流动相梯度洗脱,使用以Eclipse Plus C18柱和MSD检测器,对试样中的甲基磺草酮、氯氟吡氧乙酸异辛酯和莠去津进行测定,外标法定量。[结果]该分析方法甲基磺草酮、氯氟吡氧乙酸异辛酯和莠去津线性相关系数分别为0.9998、0.9994和0.9998,变异系数分别为0.67%、2.01%和0.29%,平均回收率分别为103.52%、117.74%和115.75%。[结论]该方法的操作简单,精密度、准确度和灵敏度均满足要求,可用于65%甲基磺草酮·氯氟吡氧乙酸异辛酯·莠去津可湿性粉剂含量检测。
文摘Background A new inhalable insulin aerosol （Inh-lns） was developed in China. The aim of this multicenter clinical study was to evaluate the efficacy and safety of this new Inh-lns as a treatment of type 2 diabetes. Regular porcine insulin （RI） was used as a control. Methods This study is a prospective, randomized, open-label, parallel-group multicenter clinical trial in which 253 qualified patients with type 2 diabetes received the insulin Glargine daily at bedtime plus either a pre-meal Inh-lns or a pre-meal subcutaneous RI for 12 weeks. HbAlc, fasting plasma glucose （FPG）, the 1-hour-postprandial blood glucose （1hPBG） and the 2-hour-postprandial blood glucose （2hPBG） were measured. Events were monitored for adverse effects. Results After 12 weeks, the HbAlc decreased significantly from baseline in both treatment groups, with no significant difference between the two regimens. In the Inh-lns group, FPG, both lhPBG and 2hPBG significantly declined from baseline after the 8th- and 12th-weeks of treatment. The reduced values of FPG or 1hPBG between the two groups showed a more significant hypoglycemic effect with the Inh-lns than the RI. After 12 weeks, the pulmonary carbon monoxide diffusing capacity （DLco） was significantly lower in Inh-lns group than in the RI. The main side effects of Inh-lns were coughing, excessive sputum, and hypoglycemia. Conclusions Inh-lns was effective in decreasing HbAlc like the RI. It was better in lowering the FPG and the lhPBG than the RI. Its main side effects were coughing, excessive sputum, and hypoglycemia. Also, Inh-lns slightly impaired DLco.
