For the diagnosis of glaucoma,optical coherence tomography(OCT)is a noninvasive imaging technique for the assessment of retinal layers.To accurately segment intraretinal layers in an optic nerve head(ONH)region,we pro...For the diagnosis of glaucoma,optical coherence tomography(OCT)is a noninvasive imaging technique for the assessment of retinal layers.To accurately segment intraretinal layers in an optic nerve head(ONH)region,we proposed an automatic method for the segmentation of three intraretinal layers in eye OCT scans centered on ONH.The internal limiting membrane,inner segment and outer segment,Bruch’s membrane surfaces under vascular shadows,and interaction of multiple high-reflectivity regions in the OCT image can be accurately segmented through this method.Then,we constructed a novel spatial-gradient continuity constraint,termed spatial-gradient continuity constraint,for the correction of discontinuity between adjacent image segmentation results.In our experiment,we randomly selected 20 B-scans,each annotated three retinal layers by experts.Signed distance errors of?0.80μm obtained through this method are lower than those obtained through the state-of-art method(?1.43μm).Meanwhile,the segmentation results can be used as bases for the diagnosis of glaucoma.展开更多
Taking advantage of the new standard HTML5,we designed an online tool called a browser/server-based glaucoma image database builder(BGIDB)for the demarcation of the optic disk and cup’s ellipse-like boundaries.The B-...Taking advantage of the new standard HTML5,we designed an online tool called a browser/server-based glaucoma image database builder(BGIDB)for the demarcation of the optic disk and cup’s ellipse-like boundaries.The B-spline interpolation algorithm is used,and a specially designed algorithm is proposed for classifying the disease grade according to the disc damage likelihood scale criterion,which is correlated strongly with the glaucoma process by quantity.This tool exhibits the best performance with a low overlapping error of 4.34%for the optic disk demarcation and 8.31%for the optic cup demarcation.It also has preferable time-consuming as compared to other tools and is a cross-platform system.This tool has already been utilized in building the ophthalmic image database in the cooperation of Center for Ophthalmic Imaging Research and The Second Xiangya Hospital.展开更多
基金Projects(61672542,61573380)supported by the National Natural Science Foundation of China
文摘For the diagnosis of glaucoma,optical coherence tomography(OCT)is a noninvasive imaging technique for the assessment of retinal layers.To accurately segment intraretinal layers in an optic nerve head(ONH)region,we proposed an automatic method for the segmentation of three intraretinal layers in eye OCT scans centered on ONH.The internal limiting membrane,inner segment and outer segment,Bruch’s membrane surfaces under vascular shadows,and interaction of multiple high-reflectivity regions in the OCT image can be accurately segmented through this method.Then,we constructed a novel spatial-gradient continuity constraint,termed spatial-gradient continuity constraint,for the correction of discontinuity between adjacent image segmentation results.In our experiment,we randomly selected 20 B-scans,each annotated three retinal layers by experts.Signed distance errors of?0.80μm obtained through this method are lower than those obtained through the state-of-art method(?1.43μm).Meanwhile,the segmentation results can be used as bases for the diagnosis of glaucoma.
基金Projects(61672542,61573380)supported by the National Natural Science Foundation of ChinaProject(2016zzts055)supported by Fundamental Research Funds for the Central Universities,China
文摘Taking advantage of the new standard HTML5,we designed an online tool called a browser/server-based glaucoma image database builder(BGIDB)for the demarcation of the optic disk and cup’s ellipse-like boundaries.The B-spline interpolation algorithm is used,and a specially designed algorithm is proposed for classifying the disease grade according to the disc damage likelihood scale criterion,which is correlated strongly with the glaucoma process by quantity.This tool exhibits the best performance with a low overlapping error of 4.34%for the optic disk demarcation and 8.31%for the optic cup demarcation.It also has preferable time-consuming as compared to other tools and is a cross-platform system.This tool has already been utilized in building the ophthalmic image database in the cooperation of Center for Ophthalmic Imaging Research and The Second Xiangya Hospital.
