目的循证评价黏菌素静脉联合雾化吸入治疗VAP的有效性与安全性。方法检索时间从建库截止至2018年3月。计算机检索数据库:Pubmed、Embase(Ovid)、Cochrane library(2018年3期),中国知网(China National Knowledge Infrastructure,CNKI)...目的循证评价黏菌素静脉联合雾化吸入治疗VAP的有效性与安全性。方法检索时间从建库截止至2018年3月。计算机检索数据库:Pubmed、Embase(Ovid)、Cochrane library(2018年3期),中国知网(China National Knowledge Infrastructure,CNKI)、维普数据库(VIP Database for Chinese Technical Periodicals,VIP)、万方数据库(Wan Fang Data),中国生物医学文献数据库(Chinese Biomedical Literature Database,CBM),收集关于黏菌素静脉联合吸入治疗VAP的临床对照研究。采用Mircosoft Excel、RevMan 5.3进行数据分析。结果有效性方面:①临床治愈率:静脉联合雾化吸入组总有效率显著增加[RR=1.23,95%CI(1.07,1.41),P=0.003];②微生物根除率:两组患者微生物根除率差异无统计学意义[RR=1.07,95%CI(0.92,1.24),P=0.38];③死亡率:相比对照组,试验组死亡率虽降低,但差异无统计学意义[RR=0.93,95%CI(0.79,1.09),P=0.37]。安全性方面:①急性肾损伤发生率:两组患者发生急性肾损伤的风险无明显差异(P=0.97)。结论由此可知,IV+AS联合方案在VAP治疗过程中有一定优势,但在降低死亡率、减少急性肾损伤的发生及根除微生物方面无显著差异,鉴于本研究的局限性,该结论尚待进一步验证。展开更多
Background Based on our clinical experience, the number of dorsal penile nerves in patients with primary premature ejaculation （PPE） is not consistent with the average number （2 branches）. In this study, we evalua...Background Based on our clinical experience, the number of dorsal penile nerves in patients with primary premature ejaculation （PPE） is not consistent with the average number （2 branches）. In this study, we evaluated the number and distribution of dorsal penile nerves among healthy Chinese adults and patients with PPE. Methods The dorsal nerve of the penis, the deep dorsal vein of the penis, and the dorsal artery of the penis between the deep fascia of the penis and the albuginea penis were carefully educed, observed, and counted in 38 adult autopsy specimens. The number and distribution of the dorsal penile nerve in 128 surgical patients with PPE were determined. Results The numbers of dorsal penile nerves of the 38 cases were as follows： 7 branches in 1 case; 6 branches in 1 case; 5 branches in 6 cases; 4 branches in 9 cases; 3 branches in 14 cases; and 2 branches in 7 cases. Most of the dorsal nerves were parallel to each other and in the dorsum of the penis. In only 8 cases, the branches were connected by some communicating branches. In 4 cases, 1 or 2 thin dorsal nerves continued their pathway over the ventral aspect of the penis. The average number of branches of the dorsal penile nerve in patients with PPE was 7.16. Conclusions Based on the study of 38 cases, the average number of dorsal penile nerves was 3.55 branches and that of patients with PPE was greater. These preliminary results suggest that the excessive dorsal penile nerves may have an impact on PPE via increased sensitivity and provide topographic data for the possible treatment of PPE.展开更多
文摘目的循证评价黏菌素静脉联合雾化吸入治疗VAP的有效性与安全性。方法检索时间从建库截止至2018年3月。计算机检索数据库:Pubmed、Embase(Ovid)、Cochrane library(2018年3期),中国知网(China National Knowledge Infrastructure,CNKI)、维普数据库(VIP Database for Chinese Technical Periodicals,VIP)、万方数据库(Wan Fang Data),中国生物医学文献数据库(Chinese Biomedical Literature Database,CBM),收集关于黏菌素静脉联合吸入治疗VAP的临床对照研究。采用Mircosoft Excel、RevMan 5.3进行数据分析。结果有效性方面:①临床治愈率:静脉联合雾化吸入组总有效率显著增加[RR=1.23,95%CI(1.07,1.41),P=0.003];②微生物根除率:两组患者微生物根除率差异无统计学意义[RR=1.07,95%CI(0.92,1.24),P=0.38];③死亡率:相比对照组,试验组死亡率虽降低,但差异无统计学意义[RR=0.93,95%CI(0.79,1.09),P=0.37]。安全性方面:①急性肾损伤发生率:两组患者发生急性肾损伤的风险无明显差异(P=0.97)。结论由此可知,IV+AS联合方案在VAP治疗过程中有一定优势,但在降低死亡率、减少急性肾损伤的发生及根除微生物方面无显著差异,鉴于本研究的局限性,该结论尚待进一步验证。
文摘Background Based on our clinical experience, the number of dorsal penile nerves in patients with primary premature ejaculation （PPE） is not consistent with the average number （2 branches）. In this study, we evaluated the number and distribution of dorsal penile nerves among healthy Chinese adults and patients with PPE. Methods The dorsal nerve of the penis, the deep dorsal vein of the penis, and the dorsal artery of the penis between the deep fascia of the penis and the albuginea penis were carefully educed, observed, and counted in 38 adult autopsy specimens. The number and distribution of the dorsal penile nerve in 128 surgical patients with PPE were determined. Results The numbers of dorsal penile nerves of the 38 cases were as follows： 7 branches in 1 case; 6 branches in 1 case; 5 branches in 6 cases; 4 branches in 9 cases; 3 branches in 14 cases; and 2 branches in 7 cases. Most of the dorsal nerves were parallel to each other and in the dorsum of the penis. In only 8 cases, the branches were connected by some communicating branches. In 4 cases, 1 or 2 thin dorsal nerves continued their pathway over the ventral aspect of the penis. The average number of branches of the dorsal penile nerve in patients with PPE was 7.16. Conclusions Based on the study of 38 cases, the average number of dorsal penile nerves was 3.55 branches and that of patients with PPE was greater. These preliminary results suggest that the excessive dorsal penile nerves may have an impact on PPE via increased sensitivity and provide topographic data for the possible treatment of PPE.
