Dietary Calcium Decreases Plasma Cholesterol Level only in Female but not in Male Hamster Fed a High Cholesterol Diet

Objective To investigate the effect of dietary calcium on plasma lipoprotein profile in castrated and ovariectomized hamsters. Methods Male, castrated, female and ovariectomized hamsters （n=36 each group） were randomly divided into three sub-groups （n=12） and fed one of the three diets containing O, 2, and B g calcium per kg diet for a period of six weeks. Changes in plasma lipoprotein profile were monitored at the end of week O, 3 and 6. Results Plasma total cholesterol （TC）, non-high density lipoprotein cholesterol （non-HDL-C）, triacylglycerols （TG） and TC/HDL-C were decreased only in intact female and ovariectomized hamsters. In contrast, three levels of dietary calcium had no effect on lipoprotein profiles in both intact male and castrated hamsters. Conclusion Beneficial modification of lipoprotein profile by dietary calcium was gender-dependent at least in hamsters.

血清HBsAg定量和半定量测定在临床运用中的比较

目的通过电化学发光法定量和半定量测定乙肝病毒表面抗原(HBsAg)的水平,找出更适于监控乙肝病人疾病进程的定值方法。方法采用电化学发光免疫测定法测定150例慢性乙型肝炎病人标本的HBsAg的定量与半定量值,病人分为两组:HBsAg临界值指数(COI)值小于2000组和COI大于2000组,用Spearman检验对其定量、半定量值进行相关性分析。结果受检标本中有44例HBsAg半定量结果COI<2000,二者呈正相关(R2=0.995,P<0.001),说明定量-半定量之间一致性好,二者均能准确测定HBsAg的含量;106例HBsAg半定量结果COI>2000,由于受到HOOK效应的影响,二者无显著相关(R^2=0.025,P>0.05)。结论HBsAg半定量检测,在COI值<2000时对临床疗效判别具有更高的灵敏度;在COI值>2000时,HBsAg定量检测具有较宽的检测范围(0~52000 IU/mL),可以避免HOOK效应的干扰,从而为临床治疗监测提供更为准确的结果。