卵巢癌是威胁女性生命健康最常见的恶性肿瘤之一,死亡率居妇科肿瘤之首。乳腺癌易感基因(breast cancer susceptibility gene,BRCA)是重要的肿瘤遗传易感基因,参与调节DNA的损伤修复、细胞生长及凋亡,在维持细胞遗传稳定性方面发挥着不...卵巢癌是威胁女性生命健康最常见的恶性肿瘤之一,死亡率居妇科肿瘤之首。乳腺癌易感基因(breast cancer susceptibility gene,BRCA)是重要的肿瘤遗传易感基因,参与调节DNA的损伤修复、细胞生长及凋亡,在维持细胞遗传稳定性方面发挥着不可或缺的作用。BRCA基因突变导致约80%遗传相关性卵巢癌的发生,通过对BRCA基因突变进行筛查检测,能有效评估预测卵巢癌发病风险,干预降低发病率并指导精准治疗。BRCA基因突变存在明显的种族及地域特异性,且显著影响卵巢癌发病率及发病年龄,开展多中心研究、建立相关数据库、制定符合国人的诊治标准是必然趋势。展开更多
Objective:To observe the effects and safety of Tongyan Spray(通咽喷雾剂)on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia.Methods:Seventy-two patients with ischemic post-stroke dysp...Objective:To observe the effects and safety of Tongyan Spray(通咽喷雾剂)on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia.Methods:Seventy-two patients with ischemic post-stroke dysphagia were selected and randomly assigned to a treatment group(36 cases)and a control group(36 cases)by a random number table from January 2013 to October 2014.All patients swallowed 4 kinds of barium meals with different traits respectively,and each patient underwent video fluoroscopy(VF)examination twice.In the treatment group,Tongyan Spray was sprayed to the pharynx on both sides and the middle part once respectively.The spray was applied 30 min before the second examination.Purified water at room temperature was used as placebo in the control group.The changes in the range and time of hyoid motion in both groups were observed before and after treatment.Results:Six patients dropped out in each group,and 60 patients completed the study and were included in the final analysis.Significant improvement was observed in the range of superior hyoid excursion distance and the time of hyoid motion in the treatment group compared with the control group(P<0.05).There were no obvious adverse reactions observed in oral mucosa in both groups during the whole study.Conclusion:Tongyan Spray was an effective and safe medicine for improving swallowing function in patients with ischemic post-stroke dysphagia.展开更多
文摘卵巢癌是威胁女性生命健康最常见的恶性肿瘤之一,死亡率居妇科肿瘤之首。乳腺癌易感基因(breast cancer susceptibility gene,BRCA)是重要的肿瘤遗传易感基因,参与调节DNA的损伤修复、细胞生长及凋亡,在维持细胞遗传稳定性方面发挥着不可或缺的作用。BRCA基因突变导致约80%遗传相关性卵巢癌的发生,通过对BRCA基因突变进行筛查检测,能有效评估预测卵巢癌发病风险,干预降低发病率并指导精准治疗。BRCA基因突变存在明显的种族及地域特异性,且显著影响卵巢癌发病率及发病年龄,开展多中心研究、建立相关数据库、制定符合国人的诊治标准是必然趋势。
基金Supported by the National Natural Science Foundation of China(No.81273705)。
文摘Objective:To observe the effects and safety of Tongyan Spray(通咽喷雾剂)on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia.Methods:Seventy-two patients with ischemic post-stroke dysphagia were selected and randomly assigned to a treatment group(36 cases)and a control group(36 cases)by a random number table from January 2013 to October 2014.All patients swallowed 4 kinds of barium meals with different traits respectively,and each patient underwent video fluoroscopy(VF)examination twice.In the treatment group,Tongyan Spray was sprayed to the pharynx on both sides and the middle part once respectively.The spray was applied 30 min before the second examination.Purified water at room temperature was used as placebo in the control group.The changes in the range and time of hyoid motion in both groups were observed before and after treatment.Results:Six patients dropped out in each group,and 60 patients completed the study and were included in the final analysis.Significant improvement was observed in the range of superior hyoid excursion distance and the time of hyoid motion in the treatment group compared with the control group(P<0.05).There were no obvious adverse reactions observed in oral mucosa in both groups during the whole study.Conclusion:Tongyan Spray was an effective and safe medicine for improving swallowing function in patients with ischemic post-stroke dysphagia.
