目的:调查了解近10年国内外经颅直流电刺激治疗脑卒中领域相关研究现状、热点及趋势。方法:检索中国知网和Web of Science数据库中2013~2022年关于经颅直流电刺激治疗脑卒中的相关文献,用CiteSpace软件对文献的国家、机构、作者以及关...目的:调查了解近10年国内外经颅直流电刺激治疗脑卒中领域相关研究现状、热点及趋势。方法:检索中国知网和Web of Science数据库中2013~2022年关于经颅直流电刺激治疗脑卒中的相关文献,用CiteSpace软件对文献的国家、机构、作者以及关键词等进行可视化分析。结果:(1)Web of Science数据库共纳入946篇文献,发文量总体呈上升趋势。发文量最多的国家、机构和作者依次为:美国、哈佛大学和Fregni Felipe教授,热点关键词是运动皮质、恢复、康复、瘫痪手等。近2年突现词有系统综述、吞咽功能、障碍、模型等。(2)中国知网数据库共纳入392篇文献,发文量最多的机构和作者依次为:首都医科大学宣武医院康复医学科和宋为群作者,热点关键词是失语、上肢功能、吞咽障碍和运动功能等,近2年的突现词为非侵入性脑刺激、上肢功能和脑电图等。结论:tDCS治疗脑卒中的中文文献总体发文量不高,发文机构分布不平衡且缺乏合作,今后应加强不同地区、不同机构间的合作,开展多中心、跨区域研究,应进行更深层次的作用机制研究。展开更多
It is a challenge to make thorough but efficient experimental designs for the coupled mineral dissolution and precipitation studies in a multi-mineral system, because it is difficult to speculate the best experimental...It is a challenge to make thorough but efficient experimental designs for the coupled mineral dissolution and precipitation studies in a multi-mineral system, because it is difficult to speculate the best experimental duration, optimal sampling schedule, effects of different experimental conditions, and how to maximize the experimental outputs prior to the actual experiments. Geochemical modeling is an efficient and effective tool to assist the experimental design by virtually running all scenarios of interest for the studied system and predicting the experimental outcomes. Here we demonstrated an example of geochemical modeling assisted experimental design of coupled labradorite dissolution and calcite and clayey mineral precipitation using multiple isotope tracers. In this study, labradorite(plagioclase) was chosen as the reactant because it is both a major component and one of the most reactive minerals in basalt. Following our isotope doping studies of single minerals in the last ten years, initial solutions in the simulations were doped withmultiple isotopes(e.g., Ca and Si). Geochemical modeling results show that the use of isotope tracers gives us orders of magnitude more sensitivity than the conventional method based on concentrations and allows us to decouple dissolution and precipitation reactions at near-equilibrium condition. The simulations suggest that the precise unidirectional dissolution rates can inform us which rate laws plagioclase dissolution has followed. Calcite precipitation occurred at near-equilibrium and the multiple isotope tracer experiments would provide near-equilibrium precipitation rates, which was a challenge for the conventional concentration-based experiments. In addition, whether the precipitation of clayey phases is the rate-limiting step in some multi-mineral systems will be revealed. Overall, the modeling results of multimineral reaction kinetics will improve the understanding of the coupled dissolution–precipitation in the multi-mineral systems and the quality of geochemical modeling prediction of CO_(2) removal and storage efficacy in the basalt systems.展开更多
Objective:This study aims to explore the current research status,hotspots,and trends of the emerging nursing model of“Internet+nursing service”in China,and to provide theoretical references for further research and ...Objective:This study aims to explore the current research status,hotspots,and trends of the emerging nursing model of“Internet+nursing service”in China,and to provide theoretical references for further research and development.Methods:The literature related to“Internet+nursing service”was retrieved from the China National Knowledge Infrastructure(CNKI),Wanfang database,VIP database,and SinoMed.Subsequently,visual analysis was performed using the CiteSpace scientific knowledge mapping software.Results:A total of 1223 articles were included.The number of papers published in this field has been increasing yearly,and a core group of authors has been formed.Research institutions are mainly comprised of universities and hospitals and a high percentage of projects were funded provincially and municipally,while the least percentage of projects were funded nationally.The main research hotspots include the nurse standardized management for online appointments,the current application situation for the nursing model,and factors influencing its application amongst the elderly and also in women and children’s groups.Conclusion:Although the“Internet+nursing service”in China is still in its early stages,considerable progress has been made in relevant research.Future research should focus on identifying and omitting factors that hinder the industry’s growth,thereby establishing an effective long-term model of care.展开更多
目的总结芬太尼类药物制剂及临床应用的研究进展,为临床用药提供参考。方法采用计算机检索中国知网(CNKI)、维普(VIP)、万方(WanFang)及Web of Science,PubMed,Springer,Elsevier数据库和国家药品监督管理局(NMPA)、美国食品和药物管理...目的总结芬太尼类药物制剂及临床应用的研究进展,为临床用药提供参考。方法采用计算机检索中国知网(CNKI)、维普(VIP)、万方(WanFang)及Web of Science,PubMed,Springer,Elsevier数据库和国家药品监督管理局(NMPA)、美国食品和药物管理局(FDA)、欧洲药品管理局(EMA)官方网站2013年1月至2023年7月的芬太尼相关文献,从药物制剂、临床应用、药品不良反应、药物滥用等方向梳理研究概况。结果芬太尼作为阿片类麻醉镇痛药物,广泛用于联合麻醉、分娩镇痛,在大型手术镇痛治疗及癌痛管理方面具有独特优势,但引发的嗜睡、恶心、呼吸抑制、成瘾等ADR不容忽视。我国对芬太尼类药物实行整类列管;其已上市剂型主要有注射剂、口服制剂、透皮贴剂等,具有有效的疼痛缓解作用与良好的安全性和耐受性。临床使用过程中需根据制剂的特点进行选择,以减少ADR。结论开发芬太尼新剂型对提高芬太尼类药物的使用安全性和防止滥用具有重要意义。展开更多
文摘目的:调查了解近10年国内外经颅直流电刺激治疗脑卒中领域相关研究现状、热点及趋势。方法:检索中国知网和Web of Science数据库中2013~2022年关于经颅直流电刺激治疗脑卒中的相关文献,用CiteSpace软件对文献的国家、机构、作者以及关键词等进行可视化分析。结果:(1)Web of Science数据库共纳入946篇文献,发文量总体呈上升趋势。发文量最多的国家、机构和作者依次为:美国、哈佛大学和Fregni Felipe教授,热点关键词是运动皮质、恢复、康复、瘫痪手等。近2年突现词有系统综述、吞咽功能、障碍、模型等。(2)中国知网数据库共纳入392篇文献,发文量最多的机构和作者依次为:首都医科大学宣武医院康复医学科和宋为群作者,热点关键词是失语、上肢功能、吞咽障碍和运动功能等,近2年的突现词为非侵入性脑刺激、上肢功能和脑电图等。结论:tDCS治疗脑卒中的中文文献总体发文量不高,发文机构分布不平衡且缺乏合作,今后应加强不同地区、不同机构间的合作,开展多中心、跨区域研究,应进行更深层次的作用机制研究。
基金partially supported by U.S. National Science Foundation grants EAR-2221907partly sponsored by agencies of the United States Government。
文摘It is a challenge to make thorough but efficient experimental designs for the coupled mineral dissolution and precipitation studies in a multi-mineral system, because it is difficult to speculate the best experimental duration, optimal sampling schedule, effects of different experimental conditions, and how to maximize the experimental outputs prior to the actual experiments. Geochemical modeling is an efficient and effective tool to assist the experimental design by virtually running all scenarios of interest for the studied system and predicting the experimental outcomes. Here we demonstrated an example of geochemical modeling assisted experimental design of coupled labradorite dissolution and calcite and clayey mineral precipitation using multiple isotope tracers. In this study, labradorite(plagioclase) was chosen as the reactant because it is both a major component and one of the most reactive minerals in basalt. Following our isotope doping studies of single minerals in the last ten years, initial solutions in the simulations were doped withmultiple isotopes(e.g., Ca and Si). Geochemical modeling results show that the use of isotope tracers gives us orders of magnitude more sensitivity than the conventional method based on concentrations and allows us to decouple dissolution and precipitation reactions at near-equilibrium condition. The simulations suggest that the precise unidirectional dissolution rates can inform us which rate laws plagioclase dissolution has followed. Calcite precipitation occurred at near-equilibrium and the multiple isotope tracer experiments would provide near-equilibrium precipitation rates, which was a challenge for the conventional concentration-based experiments. In addition, whether the precipitation of clayey phases is the rate-limiting step in some multi-mineral systems will be revealed. Overall, the modeling results of multimineral reaction kinetics will improve the understanding of the coupled dissolution–precipitation in the multi-mineral systems and the quality of geochemical modeling prediction of CO_(2) removal and storage efficacy in the basalt systems.
基金Policy Theory Research Project of Zhejiang Provincial Civil Affairs Department(No.ZMKT202211)Medical and Health Technology Plan of Zhejiang Province(No.2022507615)。
文摘Objective:This study aims to explore the current research status,hotspots,and trends of the emerging nursing model of“Internet+nursing service”in China,and to provide theoretical references for further research and development.Methods:The literature related to“Internet+nursing service”was retrieved from the China National Knowledge Infrastructure(CNKI),Wanfang database,VIP database,and SinoMed.Subsequently,visual analysis was performed using the CiteSpace scientific knowledge mapping software.Results:A total of 1223 articles were included.The number of papers published in this field has been increasing yearly,and a core group of authors has been formed.Research institutions are mainly comprised of universities and hospitals and a high percentage of projects were funded provincially and municipally,while the least percentage of projects were funded nationally.The main research hotspots include the nurse standardized management for online appointments,the current application situation for the nursing model,and factors influencing its application amongst the elderly and also in women and children’s groups.Conclusion:Although the“Internet+nursing service”in China is still in its early stages,considerable progress has been made in relevant research.Future research should focus on identifying and omitting factors that hinder the industry’s growth,thereby establishing an effective long-term model of care.
文摘目的总结芬太尼类药物制剂及临床应用的研究进展,为临床用药提供参考。方法采用计算机检索中国知网(CNKI)、维普(VIP)、万方(WanFang)及Web of Science,PubMed,Springer,Elsevier数据库和国家药品监督管理局(NMPA)、美国食品和药物管理局(FDA)、欧洲药品管理局(EMA)官方网站2013年1月至2023年7月的芬太尼相关文献,从药物制剂、临床应用、药品不良反应、药物滥用等方向梳理研究概况。结果芬太尼作为阿片类麻醉镇痛药物,广泛用于联合麻醉、分娩镇痛,在大型手术镇痛治疗及癌痛管理方面具有独特优势,但引发的嗜睡、恶心、呼吸抑制、成瘾等ADR不容忽视。我国对芬太尼类药物实行整类列管;其已上市剂型主要有注射剂、口服制剂、透皮贴剂等,具有有效的疼痛缓解作用与良好的安全性和耐受性。临床使用过程中需根据制剂的特点进行选择,以减少ADR。结论开发芬太尼新剂型对提高芬太尼类药物的使用安全性和防止滥用具有重要意义。
