Oleanolic acid(OA),a pentacyclic triterpenoid,exhibits a broad spectrum of biological activities,including antitumor,antiviral,antibacterial,anti-inflammatory,hepatoprotective,hypoglycemic,and hypolipidemic effects.Si...Oleanolic acid(OA),a pentacyclic triterpenoid,exhibits a broad spectrum of biological activities,including antitumor,antiviral,antibacterial,anti-inflammatory,hepatoprotective,hypoglycemic,and hypolipidemic effects.Since its initial isolation and identification,numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives.Despite this,there has been a dearth of comprehensive reviews in the past two decades,leading to challenges in subsequent research on OA.Based on the main biological activities of OA,this paper comprehensively summarized the modification strategies and structureactivity relationships(SARs)of OA and its derivatives to provide valuable reference for future investigations into OA.展开更多
Fifteen novel 3-oxo-oleanolic acid esters bearing aryl substituted 1,2,3-triazolyl methyl moiety weresynthesized via the method of Copper（I）-catalyzed Huisgen cycloaddifion. The cytotoxicity evaluation results of th...Fifteen novel 3-oxo-oleanolic acid esters bearing aryl substituted 1,2,3-triazolyl methyl moiety weresynthesized via the method of Copper（I）-catalyzed Huisgen cycloaddifion. The cytotoxicity evaluation results of thesecompounds against five human tumor cell lines show that most of these compounds presented potent activity andselectivity against A375-S2 and HT1080 cells. Compound 6c, with a p-NO2 at the bezene ring, possesses the bestinhibitory activity against A375-S2（IC50=2.82 μmol/L） and HT1080（IC50=1.69 μmol/L）.展开更多
A series of pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione derivatives was designed and synthesized,and their neuroprotective activity against SH-SY5Y cell injury induced by N-methyl-D-aspartic acid(NMDA)was evaluated.A...A series of pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione derivatives was designed and synthesized,and their neuroprotective activity against SH-SY5Y cell injury induced by N-methyl-D-aspartic acid(NMDA)was evaluated.All the compounds showed significant neuroprotective effects,especially B16,which showed excellent performance and better activity than the positive control ifenprodil(B16:56.2%±0.6%;ifenprodil:41.0%±2.7%).Further investigation indicated that B16 could attenuate the Ca^(2+)influx induced by NMDA in SH-SY5Y cells and Western blotting also showed that B16 could attenuate the NR2B upregulation in SH-SY5Y cells induced by NMDA.The molecular docking results showed that compound B16 fitted in the binding pocket of NR2B-NMDAR well and could interact with binding sites of compounds 1 and 2 simultaneously.The ADME/Tox prediction results suggested that compound B16 had good blood-brain barrier(BBB)permeability and the zero alert of Pan Assay Interference Structures(PAINS)indicated that B16 could not elicit false-positive activities.These results strongly suggest that B16 is a promising and effective candidate neuroprotective compound,and that NR2B-NMDAR is a potential target of B16.展开更多
The management of a cooling-water supply system in a nuclear reactor is performed by valve and reactor coolant pump(RCP)control,which regulates both the pressure and the discharge between certain limits.However,the RC...The management of a cooling-water supply system in a nuclear reactor is performed by valve and reactor coolant pump(RCP)control,which regulates both the pressure and the discharge between certain limits.However,the RCP has a significant unsteady flow when operating at different conditions.The unsteady pressure pulsation and radial force vector are difficult to calculate because these are affected by the transient properties of the unsteady flow.This study explores the use of a commercial Computational Fluid Dynamics(CFD)code to comprehensively estimate the unsteady flow of the RCP.The full 3D-URANS equations were solved for different flow rates,and some optimised cases for the unsteady flow were proposed.The results showed that the numerical predictions were validated with the experimental data of a model pump.The code was used to estimate the velocity streamlines,pressure pulsation and radial force vector in the steady and transient conditions.The flow rates were not equal for the inner and outer passage in the double volute casing.Additionally,the pulsation of the pressure and radial force was effectively reduced by optimising the staggered angleα.An optimal case was observed whenα=30°.展开更多
基金supported by the Lianyungang Postdoctoral Research Funding Program(No.LYG20210018).
文摘Oleanolic acid(OA),a pentacyclic triterpenoid,exhibits a broad spectrum of biological activities,including antitumor,antiviral,antibacterial,anti-inflammatory,hepatoprotective,hypoglycemic,and hypolipidemic effects.Since its initial isolation and identification,numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives.Despite this,there has been a dearth of comprehensive reviews in the past two decades,leading to challenges in subsequent research on OA.Based on the main biological activities of OA,this paper comprehensively summarized the modification strategies and structureactivity relationships(SARs)of OA and its derivatives to provide valuable reference for future investigations into OA.
文摘Fifteen novel 3-oxo-oleanolic acid esters bearing aryl substituted 1,2,3-triazolyl methyl moiety weresynthesized via the method of Copper（I）-catalyzed Huisgen cycloaddifion. The cytotoxicity evaluation results of thesecompounds against five human tumor cell lines show that most of these compounds presented potent activity andselectivity against A375-S2 and HT1080 cells. Compound 6c, with a p-NO2 at the bezene ring, possesses the bestinhibitory activity against A375-S2（IC50=2.82 μmol/L） and HT1080（IC50=1.69 μmol/L）.
基金This work was supported by the National Natural Science Foundation of China(No.21977074)the Science and Technology Projects from the Educational Department of Liaoning Province,China(No.2019LQN02).
文摘A series of pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione derivatives was designed and synthesized,and their neuroprotective activity against SH-SY5Y cell injury induced by N-methyl-D-aspartic acid(NMDA)was evaluated.All the compounds showed significant neuroprotective effects,especially B16,which showed excellent performance and better activity than the positive control ifenprodil(B16:56.2%±0.6%;ifenprodil:41.0%±2.7%).Further investigation indicated that B16 could attenuate the Ca^(2+)influx induced by NMDA in SH-SY5Y cells and Western blotting also showed that B16 could attenuate the NR2B upregulation in SH-SY5Y cells induced by NMDA.The molecular docking results showed that compound B16 fitted in the binding pocket of NR2B-NMDAR well and could interact with binding sites of compounds 1 and 2 simultaneously.The ADME/Tox prediction results suggested that compound B16 had good blood-brain barrier(BBB)permeability and the zero alert of Pan Assay Interference Structures(PAINS)indicated that B16 could not elicit false-positive activities.These results strongly suggest that B16 is a promising and effective candidate neuroprotective compound,and that NR2B-NMDAR is a potential target of B16.
基金the financial support provided by the National Natural Science Foundation of China(51806053)the University Synergy Innovation Program of Anhui Province under Grant No.GXXT-2019-004Anhui Provincial Key Research and Development Program(Grant No.201904a05020070,1804a09020012 and 1804a09020007)。
文摘The management of a cooling-water supply system in a nuclear reactor is performed by valve and reactor coolant pump(RCP)control,which regulates both the pressure and the discharge between certain limits.However,the RCP has a significant unsteady flow when operating at different conditions.The unsteady pressure pulsation and radial force vector are difficult to calculate because these are affected by the transient properties of the unsteady flow.This study explores the use of a commercial Computational Fluid Dynamics(CFD)code to comprehensively estimate the unsteady flow of the RCP.The full 3D-URANS equations were solved for different flow rates,and some optimised cases for the unsteady flow were proposed.The results showed that the numerical predictions were validated with the experimental data of a model pump.The code was used to estimate the velocity streamlines,pressure pulsation and radial force vector in the steady and transient conditions.The flow rates were not equal for the inner and outer passage in the double volute casing.Additionally,the pulsation of the pressure and radial force was effectively reduced by optimising the staggered angleα.An optimal case was observed whenα=30°.
