AIM To investigate the role of apolipoprotein E (apoE) polymorphism in the lithogenesis of gallstone and the hereditary pathogenesis of the disease.METHODS Polymerase chain reaction (PCR)was used to study apoE phenoty...AIM To investigate the role of apolipoprotein E (apoE) polymorphism in the lithogenesis of gallstone and the hereditary pathogenesis of the disease.METHODS Polymerase chain reaction (PCR)was used to study apoE phenotypes and allelefrequencies in patients with gallstones and control, and the fasting serum lipids of subjectswere also measured by enzymatic methods.RESULTS The levels of triglyceride (TG) andvery low density lipoprotein cholesterol (VLDLC) were much higher in Ez/, patients than that inE,/, control. E,/, patients were accompanied withremarkably low levels of high density lipoproteincholesterol (HDLC) and its subforms. But in E,/#patients there were only slight changes in levelsof VLDLC and low density lipoprotein cholesterol (LDL--C).CONCLUSION Different apoE phenotype patientswith gallstones have different cheracteristics ofdyslipidemia and the average level of serum lipids in patients with gallstones are higher thansubjects without gallstones in the same apoEgene phenotype. EZ allele is possibly one of thedangerous factors in the lithogenesis of cholecystolithiasis.展开更多
Biliary papillomatosis （BP） is an extremely rare pathological condition, which is characterized by papillary proliferation of the bile duct epithelia. Although initially thought to be a benign entity, this tumor has...Biliary papillomatosis （BP） is an extremely rare pathological condition, which is characterized by papillary proliferation of the bile duct epithelia. Although initially thought to be a benign entity, this tumor has been shown to have a tendency for malignant transformation. As reported in the literature, malignant degeneration occurs in 20% to 35% of cases. Because patients typically present with abdominal pain, obstructive jaundice and fever, they are usually mistaken as having more serious pathology such as cholangiocarcinoma, cholangitis and so forth. In general, the rate of preoperative diagnosis is very low. At present, the number of published articles about this illness is limited, mainly as single case reports. In addition, the diagnosis, treatment and prognosis of BP have not been well known. We, therefore, discuss age, gender, clinical manifestations, diagnostic approaches, histopathological findings, treatments and prognosis by reviewing the clinical data of eighteen patients with BP treated in our hospital, so as to better understand this rare illness.展开更多
基金Project supported by National Natural Science Foundation of China,No.39670709.
文摘AIM To investigate the role of apolipoprotein E (apoE) polymorphism in the lithogenesis of gallstone and the hereditary pathogenesis of the disease.METHODS Polymerase chain reaction (PCR)was used to study apoE phenotypes and allelefrequencies in patients with gallstones and control, and the fasting serum lipids of subjectswere also measured by enzymatic methods.RESULTS The levels of triglyceride (TG) andvery low density lipoprotein cholesterol (VLDLC) were much higher in Ez/, patients than that inE,/, control. E,/, patients were accompanied withremarkably low levels of high density lipoproteincholesterol (HDLC) and its subforms. But in E,/#patients there were only slight changes in levelsof VLDLC and low density lipoprotein cholesterol (LDL--C).CONCLUSION Different apoE phenotype patientswith gallstones have different cheracteristics ofdyslipidemia and the average level of serum lipids in patients with gallstones are higher thansubjects without gallstones in the same apoEgene phenotype. EZ allele is possibly one of thedangerous factors in the lithogenesis of cholecystolithiasis.
文摘Biliary papillomatosis （BP） is an extremely rare pathological condition, which is characterized by papillary proliferation of the bile duct epithelia. Although initially thought to be a benign entity, this tumor has been shown to have a tendency for malignant transformation. As reported in the literature, malignant degeneration occurs in 20% to 35% of cases. Because patients typically present with abdominal pain, obstructive jaundice and fever, they are usually mistaken as having more serious pathology such as cholangiocarcinoma, cholangitis and so forth. In general, the rate of preoperative diagnosis is very low. At present, the number of published articles about this illness is limited, mainly as single case reports. In addition, the diagnosis, treatment and prognosis of BP have not been well known. We, therefore, discuss age, gender, clinical manifestations, diagnostic approaches, histopathological findings, treatments and prognosis by reviewing the clinical data of eighteen patients with BP treated in our hospital, so as to better understand this rare illness.
