盆腔器官脱垂(pelvic organ prolapse,POP)是中老年女性常见的妇科疾病,研究表明大约30%~50%的女性会出现POP,且随着年龄增长,患病风险增加。可以预见,随着人口的老龄化,POP对女性患者和医疗系统的负担将越来越重[1]。POP是一种多病因疾...盆腔器官脱垂(pelvic organ prolapse,POP)是中老年女性常见的妇科疾病,研究表明大约30%~50%的女性会出现POP,且随着年龄增长,患病风险增加。可以预见,随着人口的老龄化,POP对女性患者和医疗系统的负担将越来越重[1]。POP是一种多病因疾病,流行病学研究表明,POP与年龄、体内激素、长期腹压增加和产科因素(如产次、婴儿体重、会阴侧切等)密切相关[2]。展开更多
The synthesis,characterization and luminescent properties of aluminum complexes containing a dianionic N-aryloxo functionalized β-ketoiminate ligand are presented.4-(2-Hydroxy-5-R-phenyl)imino-2-pentanone (R=Me,L 1 H...The synthesis,characterization and luminescent properties of aluminum complexes containing a dianionic N-aryloxo functionalized β-ketoiminate ligand are presented.4-(2-Hydroxy-5-R-phenyl)imino-2-pentanone (R=Me,L 1 H 2;R=tert-butyl,L 2 H 2) ligands reacted with AlEt 3 in tetrahydrofuran to give the aluminum complexes (L 1 AlEt) 2 (1) and (L 2 AlEt) 2 (2) in reasonable isolated yields.X-ray diffraction revealed that complexes 1 and 2 have solvent-free centrosymmetric dimeric structures,and each aluminum center has distorted trigonal bipyramidal geometry.At room temperature,complexes 1 and 2 exhibit blue photoluminescence in acetonitrile with maximum emission wavelengths of 419 and 413 nm,respectively.展开更多
文摘目的研究孕期野百合碱(monocrotaline,MCT)暴露的胎鼠胆固醇水平改变及其原因。方法受孕Wistar大鼠于孕9～20天(gestation day,GD)每天灌胃给予20 mg·kg-1MCT,孕鼠于GD 20处死,取雌雄性胎鼠并收集母胎血、胎盘和胎肝,检测母血胆汁酸及母、胎血胆固醇水平,以及胎盘胆固醇转运和胎肝胆固醇合成、转运相关基因表达。结果与对照组相比,MCT组母血胆汁酸水平增高,总胆固醇(total cholesterol,TCH)水平升高。雄性胎血TCH和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平升高,雌雄性胎盘低密度脂蛋白受体(low-density lipoprotein receptor,LDLR)、B类I型清道夫受体(scavenger receptor class B type I,SR-B1)、三磷酸腺苷结合盒转运体A1(adenosine triphosphate binding cassette transporter A1,ABCA1)基因表达上调,而雌雄性胎肝3-羟基-3-甲基戊二酰辅酶A还原酶(3-hydroxy-3-methylglutaryl coenzyme A reductase,HMGCR)、SR-B1、LDLR mR NA表达下调。结论孕期MCT暴露所致母鼠血胆汁酸水平增高可引起母鼠高胆固醇血症,增加胎盘胆固醇转运体表达,导致胎鼠高胆固醇血症。胎肝胆固醇转运相关基因表达降低,提示孕期MCT暴露可造成胎肝的胆固醇代谢稳态改变。
文摘盆腔器官脱垂(pelvic organ prolapse,POP)是中老年女性常见的妇科疾病,研究表明大约30%~50%的女性会出现POP,且随着年龄增长,患病风险增加。可以预见,随着人口的老龄化,POP对女性患者和医疗系统的负担将越来越重[1]。POP是一种多病因疾病,流行病学研究表明,POP与年龄、体内激素、长期腹压增加和产科因素(如产次、婴儿体重、会阴侧切等)密切相关[2]。
基金supported by the National Natural Science Foundation of China (20771078 and 20972108)the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (07KJA15014)the Qing Lan Project
文摘The synthesis,characterization and luminescent properties of aluminum complexes containing a dianionic N-aryloxo functionalized β-ketoiminate ligand are presented.4-(2-Hydroxy-5-R-phenyl)imino-2-pentanone (R=Me,L 1 H 2;R=tert-butyl,L 2 H 2) ligands reacted with AlEt 3 in tetrahydrofuran to give the aluminum complexes (L 1 AlEt) 2 (1) and (L 2 AlEt) 2 (2) in reasonable isolated yields.X-ray diffraction revealed that complexes 1 and 2 have solvent-free centrosymmetric dimeric structures,and each aluminum center has distorted trigonal bipyramidal geometry.At room temperature,complexes 1 and 2 exhibit blue photoluminescence in acetonitrile with maximum emission wavelengths of 419 and 413 nm,respectively.
