目的通过meta分析对比任务导向性训练(task-oriented training,TOT)与常规康复训练治疗卒中后患者平衡功能的疗效差异,探讨TOT治疗卒中患者平衡功能的效果。方法计算机检索Embase、PubMed、Cochrane、Web of Science以及中国知网、万方...目的通过meta分析对比任务导向性训练(task-oriented training,TOT)与常规康复训练治疗卒中后患者平衡功能的疗效差异,探讨TOT治疗卒中患者平衡功能的效果。方法计算机检索Embase、PubMed、Cochrane、Web of Science以及中国知网、万方、维普数据库中从建库至2022年12月正式发表的关于TOT对卒中平衡功能影响的随机对照试验。结局指标包括Berg平衡量表(Berg balance scale,BBS)、起立-行走计时测试(timed up and go test,TUGT)、改良Barthel指数(modified Barthel index,MBI)、6分钟步行测试(6 minute walk test,6MWT)以及Fugl-Meyer评定量表下肢部分(Fugl-Meyer assessment-lower extremity,FMA-LE)。由两名研究者独立筛选文献,使用Cochrane偏倚风险评估工具评估文献质量并提取数据,采用RevMan 5.4软件对各项指标进行meta分析。结果本研究共纳入9项随机对照试验,包括474例受试者,其中TOT组238例,对照组(常规治疗)236例。meta分析结果显示,TOT组BBS评分(MD4.11,95%CI2.76~5.45,P<0.001),TUGT评分(MD-3.24,95%CI-4.72~-1.75,P<0.001),MBI评分(MD9.55,95%CI5.05~14.05,P<0.001),FMA-LE评分(MD3.92,95%CI2.50~5.35,P<0.001)与对照组相比,差异均有统计学意义,TOT组的改善更显著。在6MWT方面,TOT组与对照组的改善差异无统计学意义。结论TOT能改善卒中后患者的平衡控制能力,且比常规训练更有效,对患者下肢运动功能、功能灵活性和日常生活活动能力方面也有积极的影响,但对心肺功能无显著影响。展开更多
Objective: To find a more effective method of topical transdermal delivery of curcumin. Methods: We prepared curcumin carbopol(CRB) 974P and hydroxypropylcellulose(HPC) gel formulations containing menthol or Azone as ...Objective: To find a more effective method of topical transdermal delivery of curcumin. Methods: We prepared curcumin carbopol(CRB) 974P and hydroxypropylcellulose(HPC) gel formulations containing menthol or Azone as permeation enhancers. In this study, negative mode electrospray ionization and a triple quadruple LC/MS/MS instrument operated in multiple reaction mode was used for curcumin detection. The assay was linear over a concentration range of 10 ng/mL to 400 ng/mL for curcumin(average R2= 0.997 2). Excised nude mouse dorsal side skin was used in an in vitro skin permeation study performed using the method of Franz. Results: Our results showed that all of the topical gel formulations we developed were free from skin irritation. The percutaneous flux and enhancement ratio of curcumin across nude mouse epidermis were enhanced markedly by the addition of menthol or Azone to both types of gel formulations. We found that the HPC gels containing quantities of Azone showed an enhanced permeation effect as compared to gels containing menthol. In the case of HPC gels containing Azone, the increase in permeability was significant(P<0.05) as compared to the gels containing menthol. Conclusion: Azone shows a significantly more remarkable permeation effect than menthol. As such, this novel delivery strategy offers significant promise and is worthy of further exploration in attempts to enhance the medicinal application of curcumin.展开更多
文摘目的通过meta分析对比任务导向性训练(task-oriented training,TOT)与常规康复训练治疗卒中后患者平衡功能的疗效差异,探讨TOT治疗卒中患者平衡功能的效果。方法计算机检索Embase、PubMed、Cochrane、Web of Science以及中国知网、万方、维普数据库中从建库至2022年12月正式发表的关于TOT对卒中平衡功能影响的随机对照试验。结局指标包括Berg平衡量表(Berg balance scale,BBS)、起立-行走计时测试(timed up and go test,TUGT)、改良Barthel指数(modified Barthel index,MBI)、6分钟步行测试(6 minute walk test,6MWT)以及Fugl-Meyer评定量表下肢部分(Fugl-Meyer assessment-lower extremity,FMA-LE)。由两名研究者独立筛选文献,使用Cochrane偏倚风险评估工具评估文献质量并提取数据,采用RevMan 5.4软件对各项指标进行meta分析。结果本研究共纳入9项随机对照试验,包括474例受试者,其中TOT组238例,对照组(常规治疗)236例。meta分析结果显示,TOT组BBS评分(MD4.11,95%CI2.76~5.45,P<0.001),TUGT评分(MD-3.24,95%CI-4.72~-1.75,P<0.001),MBI评分(MD9.55,95%CI5.05~14.05,P<0.001),FMA-LE评分(MD3.92,95%CI2.50~5.35,P<0.001)与对照组相比,差异均有统计学意义,TOT组的改善更显著。在6MWT方面,TOT组与对照组的改善差异无统计学意义。结论TOT能改善卒中后患者的平衡控制能力,且比常规训练更有效,对患者下肢运动功能、功能灵活性和日常生活活动能力方面也有积极的影响,但对心肺功能无显著影响。
基金Supported by the National Natural Science Foundation of China(81173130)
文摘Objective: To find a more effective method of topical transdermal delivery of curcumin. Methods: We prepared curcumin carbopol(CRB) 974P and hydroxypropylcellulose(HPC) gel formulations containing menthol or Azone as permeation enhancers. In this study, negative mode electrospray ionization and a triple quadruple LC/MS/MS instrument operated in multiple reaction mode was used for curcumin detection. The assay was linear over a concentration range of 10 ng/mL to 400 ng/mL for curcumin(average R2= 0.997 2). Excised nude mouse dorsal side skin was used in an in vitro skin permeation study performed using the method of Franz. Results: Our results showed that all of the topical gel formulations we developed were free from skin irritation. The percutaneous flux and enhancement ratio of curcumin across nude mouse epidermis were enhanced markedly by the addition of menthol or Azone to both types of gel formulations. We found that the HPC gels containing quantities of Azone showed an enhanced permeation effect as compared to gels containing menthol. In the case of HPC gels containing Azone, the increase in permeability was significant(P<0.05) as compared to the gels containing menthol. Conclusion: Azone shows a significantly more remarkable permeation effect than menthol. As such, this novel delivery strategy offers significant promise and is worthy of further exploration in attempts to enhance the medicinal application of curcumin.
