Calculation of response and thindown of V-79 cell for ion irradiation

A cellular survival model and the cross section calculation with low and high LET for ion irradiation were presented. Based on our formula of surviving fraction calculation, the survival data of Chinese hamster cell (V-79 ) for ion irradiation including He, Li, B, C, O, Ne and Ar were calculated; the cross sections for ion irradiation includ- ing He, Ni, C, Ar, Kr, Xe and U were shown. The calculated results show that the presented model is a good descrip- tion of radiation effects of V-79 cell for different ion irradiation. In this model splitting energy between ion-kill mode and gamma-kill model is avoided, the calculated results of cross section needn’t be multiplied by a factor to fit the experimental data.

表皮生长因子和基质金属蛋白酶2、9在妊高征患者胎盘中表达水平与围产儿结局的相关性研究

目的探讨妊娠期高血压疾病患者胎盘组织中表皮生长因子(EGF)和基质金属蛋白酶2、9(MMP-2、MMP-9)的表达水平与围产儿结局的相关性。方法选择2015年7月-2018年12月温州市中医院妇产科收治住院的妊娠期高血压疾病患者48例为研究组,同期本院收治的正常孕妇45例为对照组。收集2组的胎盘组织标本,采用免疫组化法检测2组胎盘组织中EGF和MMP-2、MMP-9的表达。结果研究组患者胎盘组织中EGF和MMP-2、MMP-9蛋白阳性表达率均明显低于对照组(χ2=11.702、10.5019.340,P<0.01),围产儿结局不良患者胎盘组织中EGF和MMP-2、MMP-9蛋白阳性表达率明显低于围产儿结局正常患者(χ2值分别为8.682、6.603、13.850,P<0.05)。在研究组中,胎盘组织中EGF和MMP-2、MMP-9阳性表达均与围产儿出生孕周呈正相关(r=0.715,0.658,0.691,P<0.05),与胎盘重量呈正相关(r值分别为0.382、0.341、0.338,P<0.05),与新生儿体质量呈正相关(r值分别为0.412、0.3520.347,P<0.05)。在研究组胎盘组织中EGF分别和MMP-2、MMP-9的表达均呈正相关(r值分别为0.482、0.497,P<0.05),而MMP-2和MMP-9的表达之间也呈正相关性(r=0.418,P<0.05)。结论EGF和MMP-2、MMP-9在妊娠期高血压疾病患者胎盘组织中均存在表达不足或缺失,三者参与了妊娠期高血压疾病的发生及病情发展,且与围产儿结局密切相关。