Cervical cancer(CESC)is one of the most common cancers and affects the female genital tract.Consistent HPV infection status has been determined to be a vital cause of tumorigenesis.HPV infection may induce changes to ...Cervical cancer(CESC)is one of the most common cancers and affects the female genital tract.Consistent HPV infection status has been determined to be a vital cause of tumorigenesis.HPV infection may induce changes to the immune system and limit the host’s immune response.Immunotherapy is therefore essential to improving the overall survival of both locally advanced and recurrent CESC patients.Using 304 relevant samples from TCGA,we assessed immune cell function in CESC patients to better understand the status of both tumor micro-environment cells and immune cells in CESC.Functional enrichment analysis,pathway enrichment analysis,and PPI network construction were performed to explore the differentially expressed genes(DEGs).The analysis identified 425 DEGs,which included 295 up-regulated genes and 130 down-regulated genes.We established that upregulation of CCL5 was correlated with significantly better survival,meaning that CCL5 expression could serve as a novel prognostic biomarker for CESC patients.We further focused on CCL5 as a hub gene in CESC,as it had significant correlations with increased numbers of several types of immune cells.Cell-type fractions of M1 macrophages were significantly higher in the high-immune-scores group,which was associated with better overall survival.Finally,we concluded that CCL5 is a promising prognostic biomarker for CESC,as well as a novel chemotherapeutic target.展开更多
Ionic liquids(ILs),also known as room-temperature molten salts,are solely composed of ions with melting points usually below 100℃.Because of their low volatility and vast amounts of species,ILs can serve as’green so...Ionic liquids(ILs),also known as room-temperature molten salts,are solely composed of ions with melting points usually below 100℃.Because of their low volatility and vast amounts of species,ILs can serve as’green solvents’and’designer solvents’to meet the requirements of various applications by fine-tuning their molecular structures.A good understanding of the phase behaviors of ILs is certainly fundamentally important in terms of their wide applications.This review intends to summarize the major conclusions so far drawn on phase behaviors of ILs by computational,theoretical,and experimental studies,illustrating the intrinsic relationship between their dual ionic and organic nature and the crystalline phases,nanoscale segregation liquid phase,IL crystal phases,as well as phase behaviors of their mixture with small organic molecules.展开更多
基金the National Natural Science Foundation of China(No.81802606)Key Technology Research Project of Nantong Science and Technology Bureau(MS12017013-1)Training Program of Innovation and Entrepreneurship for College Students in Jiangsu(Nos.201913993001Y and 201913993021H).
文摘Cervical cancer(CESC)is one of the most common cancers and affects the female genital tract.Consistent HPV infection status has been determined to be a vital cause of tumorigenesis.HPV infection may induce changes to the immune system and limit the host’s immune response.Immunotherapy is therefore essential to improving the overall survival of both locally advanced and recurrent CESC patients.Using 304 relevant samples from TCGA,we assessed immune cell function in CESC patients to better understand the status of both tumor micro-environment cells and immune cells in CESC.Functional enrichment analysis,pathway enrichment analysis,and PPI network construction were performed to explore the differentially expressed genes(DEGs).The analysis identified 425 DEGs,which included 295 up-regulated genes and 130 down-regulated genes.We established that upregulation of CCL5 was correlated with significantly better survival,meaning that CCL5 expression could serve as a novel prognostic biomarker for CESC patients.We further focused on CCL5 as a hub gene in CESC,as it had significant correlations with increased numbers of several types of immune cells.Cell-type fractions of M1 macrophages were significantly higher in the high-immune-scores group,which was associated with better overall survival.Finally,we concluded that CCL5 is a promising prognostic biomarker for CESC,as well as a novel chemotherapeutic target.
基金supported by the National Natural Science Foundation of China(Nos.11774357,22011530390,12047503)the Chinese Academy of Sciences(No.QYZDJ-SSWSYS01)
文摘Ionic liquids(ILs),also known as room-temperature molten salts,are solely composed of ions with melting points usually below 100℃.Because of their low volatility and vast amounts of species,ILs can serve as’green solvents’and’designer solvents’to meet the requirements of various applications by fine-tuning their molecular structures.A good understanding of the phase behaviors of ILs is certainly fundamentally important in terms of their wide applications.This review intends to summarize the major conclusions so far drawn on phase behaviors of ILs by computational,theoretical,and experimental studies,illustrating the intrinsic relationship between their dual ionic and organic nature and the crystalline phases,nanoscale segregation liquid phase,IL crystal phases,as well as phase behaviors of their mixture with small organic molecules.
