部分ESCRT亚基通过调控STING的降解调节其活性

Stimulator of interferon genes(STING),also known as MITA,ERIS,MPYS or TMEM173,is a key player in innate immunity,specifically in the typeⅠinterferon response[1-3].It is also involved in a range of non-canonical biological functions,including autophagy,cellular metabolism,translation,and DNA repair,and has implications in many diseases[4-9].After activation by its ligands,STING translocates from endoplasmic reticulum(ER),via ERGIC,Golgi apparatus and endosomes,finally to lysosomes for degradation[4-9].However,the mechanisms by which STING is delivered to lysosomes and whether this delivery process regulates STING activity remain elusive.

Fe-Based Metal-Organic Framework and Its Derivatives for Reversible Lithium Storage

The use of a Fe-based metal organic framework（MOF）, namely MIL-88B（Fe）, as active material for lithium ion batteries（LIBs） is reported for the first time in the present work. Fe-based MOF demonstrated high capacity, excellent cycling stability and rate performance when used as anode. A highly reversible capacity of 680 mAhg^（-1） after 500 cycles at a current density of 200 m A g^（-1） was obtained. In addition, Fe2O3 and Fe3O4/C composites were obtained from Fe-based MOFs through thermal treatment. Both Fe2O3 and Fe3O4/C composites demonstrated high capacity and excellent cycling stability.

Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils

Inhibitory immune receptors set thresholds for immune cell activation,and their deficiency predisposes a person to autoimmune responses.However,the agonists of inhibitory immune receptors remain largely unknown,representing untapped sources of treatments for autoimmune diseases.Here,we show that V-set and transmembrane domain-containing 1(VSTM1)is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1(Gal1)is essential for maintaining neutrophil viability mediated by downregulated reactive oxygen species production.However,in patients with systemic lupus erythematosus(SLE),circulating Gal1 is oxidized and cannot be recognized by VSTM1,leading to increased intracellular reactive oxygen species levels and reduced neutrophil viability.Dysregulated neutrophil function or death contributes significantly to the pathogenesis of SLE by providing danger molecules and autoantigens that drive the production of inflammatory cytokines and the activation of autoreactive lymphocytes.Interestingly,serum levels of glutathione,an antioxidant able to convert oxidized Gal1 to its reduced form,were negatively correlated with SLE disease activity.Taken together,our findings reveal failed inhibitory Gal1/VSTM1 pathway activation in patients with SLE and provide important insights for the development of effective targeted therapies.

Expression of the inactive ZmMEK1 induces salicylic acid accumulation and salicylic acid-dependent leaf senescence

Leaf senescence is the final leaf developmental process that is regulated by both intracellular factors and environmental conditions. The mitogen-activated protein kinase（MAPK） signaling cascades have been shown to play important roles in regulating leaf senescence; however, the component（s） downstream of the MAPK cascades in regulating leaf senescence are not fully understood. Here we showed that the transcriptions of Zm MEK1, Zm SIMK1, and Zm MPK3 were induced during dark-induced maize leaf senescence.Furthermore, in-gel kinase analysis revealed the 42 k Da MAPK was activated. Zm MEK1 interacted with Zm SIMK1 in yeast and maize mesophyll protoplasts and Zm SIMK1 was activated by Zm MEK1 in vitro. Expression of a dominant negative mutant of Zm MEK1 in Arabidopsis transgenic plants induced salicylic acid（SA） accumulation and SA-dependent leaf senescence.Zm MEK1 interacted with Arabidopsis MPK4 in yeast and High-Im pact activated MPK4 in vitro. SA treatment accelerated darkinduced maize leaf senescence. Moreover, blockage of MAPK signaling increased endogenous SA accumulation in maize leaves. These findings suggest that Zm MEK1-Zm SIMK1 cascade and its modulating SA levels play important roles in regulating leaf senescence.

Fabrication and properties of high quality InGaN-based LEDs with highly reflective nanoporous GaN mirrors

Distributed Bragg reflectors (DBRs) are essential components for the development of optoelectronic devices.In this paper, we first report the use of the nanoporous GaN (NP-GaN) DBR as a template for regrowth of InGaN-based light-emitting diodes (LEDs). The wafer-scale NP-GaN DBR, which is fabricated by electrochemical etching in a neutral solution, has a smooth surface, high reflectivity (>99.5%), and wide spectral stop band width (>70 nm). The chemical composition of the regrown LED thin film is similar to that of the reference LED, but the photoluminescence (PL) lifetime, PL intensity, and electroluminescence intensity of the LED with the DBR are enhanced several times compared to those of the reference LED. The intensity enhancement is attributed to the light reflection effect of the NP-GaN DBR and improved crystalline quality as a result of the etching scheme, whereas the enhancement of PL lifetime is attributable to the latter.