Owing to significantly prolonged survival,targeted therapy has become standardized recommendation for advanced non-small cell lung cancer patients with mutated driver genes.However,the genetic status of lung cancer pa...Owing to significantly prolonged survival,targeted therapy has become standardized recommendation for advanced non-small cell lung cancer patients with mutated driver genes.However,the genetic status of lung cancer patients is dynamic.By dynamically monitoring the evolution of genes status,differential genes and concomitant genes related to progressive disease could be confirmed early,so as to achieve a more accurate and comprehensive insight of the whole process management of targeted therapy for lung cancer patients.Under the guidance of accurate genetic testing results,it is helpful to provide patients with more effective,long-term,and stable individualized targeted therapy.展开更多
卡培他滨作为氟尿嘧啶类细胞毒药物,以手足综合征(hand and foot syndrome,HFS)为主要的不良反应,发生率相对较高,但重度的HFS发生率很低。HFS多表现为麻木、感觉异常,甚者表现为皮肤肿痛、水泡、脱皮等。卡培他滨引起HFS的发生机制仍...卡培他滨作为氟尿嘧啶类细胞毒药物,以手足综合征(hand and foot syndrome,HFS)为主要的不良反应,发生率相对较高,但重度的HFS发生率很低。HFS多表现为麻木、感觉异常,甚者表现为皮肤肿痛、水泡、脱皮等。卡培他滨引起HFS的发生机制仍在探讨中,现有研究认为与基因多态性、维生素B6缺乏、炎症反应等原因相关。基于此HFS的治疗措施亦不统一。文章通过报道中药泡洗治疗1例卡培他滨引起的以足底水泡破溃流脓,足跟外侧破溃流血为主要表现的重度HFS,对HFS的发生机制、中西医治疗策略进行了回顾总结。展开更多
基金National Natural Science Foundation of China(No.81873396)Capital Health Development Research Project(No.2018-2-4065)Project of China-Japan Friendship Hospital(No.2018-HX-26)。
文摘Owing to significantly prolonged survival,targeted therapy has become standardized recommendation for advanced non-small cell lung cancer patients with mutated driver genes.However,the genetic status of lung cancer patients is dynamic.By dynamically monitoring the evolution of genes status,differential genes and concomitant genes related to progressive disease could be confirmed early,so as to achieve a more accurate and comprehensive insight of the whole process management of targeted therapy for lung cancer patients.Under the guidance of accurate genetic testing results,it is helpful to provide patients with more effective,long-term,and stable individualized targeted therapy.
文摘卡培他滨作为氟尿嘧啶类细胞毒药物,以手足综合征(hand and foot syndrome,HFS)为主要的不良反应,发生率相对较高,但重度的HFS发生率很低。HFS多表现为麻木、感觉异常,甚者表现为皮肤肿痛、水泡、脱皮等。卡培他滨引起HFS的发生机制仍在探讨中,现有研究认为与基因多态性、维生素B6缺乏、炎症反应等原因相关。基于此HFS的治疗措施亦不统一。文章通过报道中药泡洗治疗1例卡培他滨引起的以足底水泡破溃流脓,足跟外侧破溃流血为主要表现的重度HFS,对HFS的发生机制、中西医治疗策略进行了回顾总结。
