Objective To investigate the influence of the polluted SY River on children＇s growth and sex hormones, and provide scientific data for assessment of the polluted status of the SY River. Methods The study areas were s...Objective To investigate the influence of the polluted SY River on children＇s growth and sex hormones, and provide scientific data for assessment of the polluted status of the SY River. Methods The study areas were selected randomly from the SY River Basin. Lead （Pb）, mercury （Hg）, arsenic （As）, phthalates （DEP, DBP, DMP, DEHP）, and bisphenol A （BPA） were measured both in the river water and in the drinking water. School children were selected by cluster sampling （n=254）. Physical development indexes （height, weight, bust-circumference, and skinfold thickness） and sex hormones [testosterone （T） and estradiol （E2）] were measured for all the children. Results The contents of Pb and Hg exceeded Class V standards of surface water quality in each section of the river and other indicators exceeded Class Ill. Compared to the control area, the concentrations of Pb, Hg, As, BPA, DEP, and DBP in the drinking water were significantly higher than in the polluted area （P〈0.05）. Children from the control area had significantly lower E2 and T than children from the polluted area （P〈O.05）. Among anthropometric results, only skinfold thickness had statistically significant difference between the two groups （P〈0.05）, while the other indexes showed no significant differences between the two groups （P〉0.05）. Conclusion The drinking water has been polluted by the SY River and affected serum sex hormone levels of children living in the polluted area.展开更多
The effects of fluoride exposure on thefunctions of reproductive and endocrine systemshave attracted widespread attention in academiccircle nowadays. However, it is unclear whether thegene-environment interaction may ...The effects of fluoride exposure on thefunctions of reproductive and endocrine systemshave attracted widespread attention in academiccircle nowadays. However, it is unclear whether thegene-environment interaction may modify thesecretion and activity of hypothalamus-pituitary-ovarian （HPO） axis hormones. Thus, the aim of thisstudy was to explore the influence of fluorideexposure and follicle stimulating hormone receptor（FSHR） gene polymorphism on reproductivehormones in Chinese women. A cross sectionalstudy was conducted in seven villages of HenanProvince, China during 2010-2011. A total of 679women aged 18-48 years were recruited throughcluster sampling and divided into three groups, i.e.endemic fluorosis group （EFG）, defluoridationproject group （DFPG）, and control group （CG） basedon the local fluoride concentration in drinkingwater. The serum levels of gonadotropin releasinghormone （GnRH）, follicle stimulating hormone（FSH）, luteinizing hormone （LH）, and estradiol （E2）were determined respectively and the FSHRpolymorphism was detected by real time PCR assay.The results provided the preliminary evidenceindicating the gene-environment interaction onHPO axishormones in women.展开更多
基金supported by National Major Projects of Water Issues,2009ZX07210-006-3-3
文摘Objective To investigate the influence of the polluted SY River on children＇s growth and sex hormones, and provide scientific data for assessment of the polluted status of the SY River. Methods The study areas were selected randomly from the SY River Basin. Lead （Pb）, mercury （Hg）, arsenic （As）, phthalates （DEP, DBP, DMP, DEHP）, and bisphenol A （BPA） were measured both in the river water and in the drinking water. School children were selected by cluster sampling （n=254）. Physical development indexes （height, weight, bust-circumference, and skinfold thickness） and sex hormones [testosterone （T） and estradiol （E2）] were measured for all the children. Results The contents of Pb and Hg exceeded Class V standards of surface water quality in each section of the river and other indicators exceeded Class Ill. Compared to the control area, the concentrations of Pb, Hg, As, BPA, DEP, and DBP in the drinking water were significantly higher than in the polluted area （P〈0.05）. Children from the control area had significantly lower E2 and T than children from the polluted area （P〈O.05）. Among anthropometric results, only skinfold thickness had statistically significant difference between the two groups （P〈0.05）, while the other indexes showed no significant differences between the two groups （P〉0.05）. Conclusion The drinking water has been polluted by the SY River and affected serum sex hormone levels of children living in the polluted area.
基金supported by the National Natural Science Foundation of China(No.81072247)the Education Department of Henan Province,China(No.13A330653)
文摘The effects of fluoride exposure on thefunctions of reproductive and endocrine systemshave attracted widespread attention in academiccircle nowadays. However, it is unclear whether thegene-environment interaction may modify thesecretion and activity of hypothalamus-pituitary-ovarian （HPO） axis hormones. Thus, the aim of thisstudy was to explore the influence of fluorideexposure and follicle stimulating hormone receptor（FSHR） gene polymorphism on reproductivehormones in Chinese women. A cross sectionalstudy was conducted in seven villages of HenanProvince, China during 2010-2011. A total of 679women aged 18-48 years were recruited throughcluster sampling and divided into three groups, i.e.endemic fluorosis group （EFG）, defluoridationproject group （DFPG）, and control group （CG） basedon the local fluoride concentration in drinkingwater. The serum levels of gonadotropin releasinghormone （GnRH）, follicle stimulating hormone（FSH）, luteinizing hormone （LH）, and estradiol （E2）were determined respectively and the FSHRpolymorphism was detected by real time PCR assay.The results provided the preliminary evidenceindicating the gene-environment interaction onHPO axishormones in women.
