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经硬质支气管镜冷冻肺活检对间质性肺疾病的诊断价值 被引量:7
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作者 余敏 李燕 +5 位作者 赵琪 丁晶晶 孟凡青 代静泓 蔡后荣 肖永龙 《临床肺科杂志》 2021年第12期1783-1787,1799,共6页
目的探讨经硬质支气管镜冷冻肺活检对间质性肺疾病的诊断价值和安全性。方法回顾性分析2017年12月至2019年12月期间就诊于南京大学医学院附属鼓楼医院行TBCB的91例间质性肺疾病患者及同期行TBLB的91例间质性肺疾病患者的临床影像病理资... 目的探讨经硬质支气管镜冷冻肺活检对间质性肺疾病的诊断价值和安全性。方法回顾性分析2017年12月至2019年12月期间就诊于南京大学医学院附属鼓楼医院行TBCB的91例间质性肺疾病患者及同期行TBLB的91例间质性肺疾病患者的临床影像病理资料,比较两种肺活检方法的手术情况、病理取材和诊断效率。结果TBCB组及TBLB组手术时间分别为(32.4±11.3)和(16.0±6.8)min(T=27.232,P=0.001),TBCB组及TBLB组活检标本大小分别为(9.8±3.8)和(1.8±1.2)mm 2(T=24.561,P<0.001),TBCB组及TBLB组病理诊断率分别为84.6%(77/91)和20.9%(19/91)(χ^(2)=74.158,P<0.001)。TBCB组使用球囊封堵预防性压迫止血,36例0级出血,40例1级出血,15例2级出血;TBLB组未使用球囊,56例0级出血,32例1级出血,3例2级出血(χ^(2)=13.237,P<0.001);TBCB组及TBLB组气胸发生率分别为11.0%(10/91)和8.8%(8/91)(χ^(2)=0.247,P=0.619)。结论经硬质支气管镜冷冻肺活检与常规经支气管镜肺活检相比,病理取材和诊断效率具有明显优势,安全可靠,是确诊间质性肺疾病的一种安全、有效的方法。 展开更多
关键词 硬质支气管镜 冷冻肺活检 间质性肺疾病
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血清KL-6水平在原发性干燥综合征继发间质性肺病患者诊断及病情评估中的作用 被引量:3
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作者 张君 王方萍 +6 位作者 石沈云 桂贤华 曹敏 姜涵毅 刘锐敏 蔡后荣 丁晶晶 《临床肺科杂志》 2022年第3期325-331,共7页
目的本研究旨在探讨血清学标志物在原发性干燥综合征继发间质性肺病(pSS-ILD)患者诊断和病情严重程度评估中的作用。方法回顾性分析2013年5月至2014年5月南京鼓楼医院31例间质性肺病继发干燥综合征患者的临床资料,并进行电话随访,肺炎... 目的本研究旨在探讨血清学标志物在原发性干燥综合征继发间质性肺病(pSS-ILD)患者诊断和病情严重程度评估中的作用。方法回顾性分析2013年5月至2014年5月南京鼓楼医院31例间质性肺病继发干燥综合征患者的临床资料,并进行电话随访,肺炎及健康体检者作为对照组,检测患者血清涎液化糖链抗6(KL-6)、白细胞介素-4(IL-4)、肺表面活性蛋白-D(SP-D)和转化生长因子-β(TGF-β)表达水平,分析其与疾病严重程度的关系。结果pSS-ILD患者血清KL-6水平显著高于肺炎组及健康对照组,KL-6 cut-off>858U/mL时,预测pSS-ILD敏感度、特异性分别为80.6%、100%,曲线下面积(AUC)为0.973。在KL-6水平≥1000 U/mL患者组中,血清IL-4水平显著下降,血清球蛋白、C反应蛋白(CRP)、CD4^(+)淋巴细胞数、二氧化碳分压(PaCO_(2))显著升高,用力肺活量(FVC)的值及占预计值的百分比均显著下降,以上均为P<0.05,差异有统计学意义。结论血清KL-6可作为pSS-ILD诊断及病情评估的理想血清标志物。 展开更多
关键词 原发性干燥综合征 间质性肺病 KL-6
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Pulmonary alveolar proteinosis in an indium-processing worker 被引量:22
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作者 XIAO Yong-long cai hou-rong +2 位作者 WANG Yi-hua MENG Fan-qing ZHANG De-ping 《Chinese Medical Journal》 SCIE CAS CSCD 2010年第10期1347-1350,共4页
With the increasing number of workers engaged in liquid-crystal displays (LCD) manufacturer, lung diseases related to this occupational exposure are attracting more attention. Herein we report a case of interstitial... With the increasing number of workers engaged in liquid-crystal displays (LCD) manufacturer, lung diseases related to this occupational exposure are attracting more attention. Herein we report a case of interstitial lung disease in a LCD processing worker, which was pathologically confirmed as pulmonary alveolar proteinosis (PAP). 展开更多
关键词 CHOLESTEROL INDIUM lung lavage pulmonary alveolar proteinosis
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An unusual case of welder's siderosis with local massive fibrosis: a case report 被引量:3
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作者 Ji Cheng Chen Gang +5 位作者 cai hou-rong Meng Fan-qin Chen Yan-bin Guo Ling-chuan Huang Jian-an Ling Chun-hua 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第3期552-554,共3页
Welder's siderosis was traditionally described as "benign pneumoconiosis" because of the absence of associated symptoms, functional impairment or pulmonary fibrosis. Although several authors have reported evidence ... Welder's siderosis was traditionally described as "benign pneumoconiosis" because of the absence of associated symptoms, functional impairment or pulmonary fibrosis. Although several authors have reported evidence of fibrosis in the lungs of welders, sJderosJs with local massJve fibrosis has been rarely descrJbed. In this paper, we present a case of Welder's siderosis with local massive fibrosis mimicking lung cancer. 展开更多
关键词 SIDEROSIS occupational disease FIBROSIS WELDING
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Serum cytokine levels in patients with advanced non-small cell lung cancer: correlation with clinical outcome of erlotinib treatment 被引量:2
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作者 Wang Yong-sheng Miao Li-yun +5 位作者 Liu Lu cai hou-rong Ding Jing-jing Ren Sheng-xiang Zhou cai-cun Schmid-Bindert, Gerald 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第20期3931-3935,共5页
Background Serum expression of cytokines may provide information about the clinical outcome of advanced non-small cell lung cancer (NSCLC) patients. This study aimed to investigate the relationship between serum cyt... Background Serum expression of cytokines may provide information about the clinical outcome of advanced non-small cell lung cancer (NSCLC) patients. This study aimed to investigate the relationship between serum cytokine levels and the clinical outcome of erlotinib treatment in a second or third line setting in patients with advanced NSCLC. 展开更多
关键词 lung cancer erlotinib serum cytokine clinical outcome
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Organizing pneumonia associated with common variable immunodeficiency
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作者 CAO Meng-shu cai hou-rong +2 位作者 ZHANG Ying-wei MENG Fan-qing SUN Ling-yun 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第17期3195-3197,共3页
Common variable immunodeficiency (CVID) is a rare disease characterized by recurrent pulmonary infections, hypogammaglobulinemia, and diminished specific antibody response to immunization. The estimated prevalence r... Common variable immunodeficiency (CVID) is a rare disease characterized by recurrent pulmonary infections, hypogammaglobulinemia, and diminished specific antibody response to immunization. The estimated prevalence rate of CVID ranged from 1/50 000 to 1/200 000.I The common clinical manifestations of CVID are repeated and prolonged respiratory infections. 展开更多
关键词 organizing pneumonia common variable immunodeficiency surgical lung biopsy
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