糖尿病(diabetes mellitus,DM)是目前临床医学中最普遍的代谢性疾病之一,并且已经成为全球关注的公共卫生问题。沉默信息调节因子2相关酶1(silencing information regulator 2 related enzyme 1,SIRT1)是一种腺嘌呤二核苷酸依赖性去乙...糖尿病(diabetes mellitus,DM)是目前临床医学中最普遍的代谢性疾病之一,并且已经成为全球关注的公共卫生问题。沉默信息调节因子2相关酶1(silencing information regulator 2 related enzyme 1,SIRT1)是一种腺嘌呤二核苷酸依赖性去乙酰化酶,参与糖代谢和胰岛素的分泌过程,在DM的发病机制中扮演了重要角色。糖尿病主要是由于胰岛素分泌缺乏或者胰岛素抵抗导致的代谢紊乱综合征。SIRT1不仅在β细胞中通过p53、叉头盒转录因子O(forkhead box transcription factor class O,FoxO)、烟酰胺磷酸核糖转移酶(nicotinamide phosphoribose transferase,NAMPT)等相关靶点影响胰岛素分泌;还可以通过胰岛素受体、脂联素影响胰岛素敏感性从而干扰胰岛素抵抗。此外,SIRT1还可以通过抑制NF-κB信号通路,保护胰岛β细胞免受氧化应激和炎症细胞因子的刺激。同时,SIRT1通过促进线粒体的生物发生保证机体内所有细胞活动的供能,并避免脂质的积累。白色脂肪组织(white adipose tissue,WAT)、糖异生功能异常导致的糖尿病也受到SIRT1诸多影响。本文旨在探讨SIRT1与DM的关系及其中涉及的相关信号网络。展开更多
At the beginning of 2024,the cosmetic industry is bustling with prosperity and depression.On one hand,the perfume brand DOCUMENTS and the biotechnology company BIO-REGEN received financial investments.The medical comp...At the beginning of 2024,the cosmetic industry is bustling with prosperity and depression.On one hand,the perfume brand DOCUMENTS and the biotechnology company BIO-REGEN received financial investments.The medical company Trautec started pre-listing counseling.The first new raw material in the new year was registered.While on the other hand,the packaging material company Yiside declared bankruptcy.The beauty brand MAOGEPING failed to go public through an IPO again,after eight years’failure.Jinfa Labi,Watsons and Zhonghao Biology were all mired in recession.Hope and challenge hung over the first half month of 2024.With such a“magical”start,2024 will be definitely a year full of uncertainty.展开更多
对多机器人编队的路径规划以及编队运动控制问题进行研究,给出一种多机器人路径规划及编队控制策略。基于IPOPT(Interior Point Optimizer)对A^(*)算法规划的全局路径进行优化,得到轨迹平滑的路径。根据有向图结构给出领航-跟随者型仿...对多机器人编队的路径规划以及编队运动控制问题进行研究,给出一种多机器人路径规划及编队控制策略。基于IPOPT(Interior Point Optimizer)对A^(*)算法规划的全局路径进行优化,得到轨迹平滑的路径。根据有向图结构给出领航-跟随者型仿射编队控制方法,实现机器人编队队形的控制。最后,在二维空间的封闭有障碍空间下进行编队路径规划与编队运动仿真实验。实验结果表明,该策略能够得到轨迹平滑的路径,并且编队队形收敛快速。展开更多
Governments in different regions are attaching more and more importance to the makeup industry.Ever since“the 14th Five-Year Plan”set a keynote,provinces/municipalities such as Guangdong,Shanghai and Zhejiang have r...Governments in different regions are attaching more and more importance to the makeup industry.Ever since“the 14th Five-Year Plan”set a keynote,provinces/municipalities such as Guangdong,Shanghai and Zhejiang have released policy documents to promote high-quality development of the cosmetic industry successively.From their planning blueprints,we can catch a glimpse of the makeup industry blueprint for 2025:By 2025.展开更多
文摘At the beginning of 2024,the cosmetic industry is bustling with prosperity and depression.On one hand,the perfume brand DOCUMENTS and the biotechnology company BIO-REGEN received financial investments.The medical company Trautec started pre-listing counseling.The first new raw material in the new year was registered.While on the other hand,the packaging material company Yiside declared bankruptcy.The beauty brand MAOGEPING failed to go public through an IPO again,after eight years’failure.Jinfa Labi,Watsons and Zhonghao Biology were all mired in recession.Hope and challenge hung over the first half month of 2024.With such a“magical”start,2024 will be definitely a year full of uncertainty.
文摘对多机器人编队的路径规划以及编队运动控制问题进行研究,给出一种多机器人路径规划及编队控制策略。基于IPOPT(Interior Point Optimizer)对A^(*)算法规划的全局路径进行优化,得到轨迹平滑的路径。根据有向图结构给出领航-跟随者型仿射编队控制方法,实现机器人编队队形的控制。最后,在二维空间的封闭有障碍空间下进行编队路径规划与编队运动仿真实验。实验结果表明,该策略能够得到轨迹平滑的路径,并且编队队形收敛快速。
文摘Governments in different regions are attaching more and more importance to the makeup industry.Ever since“the 14th Five-Year Plan”set a keynote,provinces/municipalities such as Guangdong,Shanghai and Zhejiang have released policy documents to promote high-quality development of the cosmetic industry successively.From their planning blueprints,we can catch a glimpse of the makeup industry blueprint for 2025:By 2025.
