目的:观察炙甘草汤联合针刺治疗老年肿瘤相关性贫血的临床疗效。方法:选择2018年12月至2021年12月在上海德济医院治疗的老年肿瘤相关性贫血患者60例,按照随机数字表法分为对照组和观察组,每组各30例。对照组给予常规西医支持治疗,观察...目的:观察炙甘草汤联合针刺治疗老年肿瘤相关性贫血的临床疗效。方法:选择2018年12月至2021年12月在上海德济医院治疗的老年肿瘤相关性贫血患者60例,按照随机数字表法分为对照组和观察组,每组各30例。对照组给予常规西医支持治疗,观察组在对照组治疗的基础上给予炙甘草汤联合针刺治疗。观察两组治疗前后血红蛋白、Karnofsky功能状态评分(Karnofsky performance status score, KPS)、外周血T细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))变化情况及临床疗效、不良反应发生情况。结果:观察组有效率为100.00%,对照组有效率为93.33%,观察组有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后血红蛋白、KPS评分均高于对照组,差异有统计学意义(P<0.05);观察组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为10.00%,对照组不良反应发生率为6.67%,两组比较差异无统计学意义(P>0.05)。结论:炙甘草汤联合针刺治疗老年肿瘤相关性贫血,可以提高临床疗效,改善患者生活质量、血红蛋白水平、外周血T细胞亚群水平。展开更多
Surface modification,as a promising approach to improve biocompatibility of biomaterials,has captured extensive close attention among many researchers.Here,micro-milling technology was used in constructing pyramid mic...Surface modification,as a promising approach to improve biocompatibility of biomaterials,has captured extensive close attention among many researchers.Here,micro-milling technology was used in constructing pyramid micro-structures on the surface of Ti-6Al-4Vimplant.Cutting parameters,including spindle speed,feed rate and depth of cut,were optimized to control the generation of burrs.In addition,low melting point alloy was selected to extend the boundary of the workpiece as supporting material to prevent the generation of top burrs.The surface topographies were characterized using scanning electron microscope and laser scanning microscope.Results showed that the dimension of burrs decreased with the decrease of depth of cut,and the size of burrs decreased with the increase of feed rate.Moreover,burrs nearly not appeared on both sides of the micro-grooves machined with low melting point alloy(LMPA)coating.Pyramid micro-structure on the workpiece surface was built successfully by combining optimized cutting parameters(S=35kr/min,Vf=60mm/min,ap=5μm)and LMPA coating.展开更多
文摘目的:观察炙甘草汤联合针刺治疗老年肿瘤相关性贫血的临床疗效。方法:选择2018年12月至2021年12月在上海德济医院治疗的老年肿瘤相关性贫血患者60例,按照随机数字表法分为对照组和观察组,每组各30例。对照组给予常规西医支持治疗,观察组在对照组治疗的基础上给予炙甘草汤联合针刺治疗。观察两组治疗前后血红蛋白、Karnofsky功能状态评分(Karnofsky performance status score, KPS)、外周血T细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))变化情况及临床疗效、不良反应发生情况。结果:观察组有效率为100.00%,对照组有效率为93.33%,观察组有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后血红蛋白、KPS评分均高于对照组,差异有统计学意义(P<0.05);观察组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为10.00%,对照组不良反应发生率为6.67%,两组比较差异无统计学意义(P>0.05)。结论:炙甘草汤联合针刺治疗老年肿瘤相关性贫血,可以提高临床疗效,改善患者生活质量、血红蛋白水平、外周血T细胞亚群水平。
基金supported by the National Natural Science Foundations of China(Nos.51175306,51425503)the Tai Shan Scholar Foundation,the Fundamental Research Funds for the Central Universities(No.2014JC020)the Opening fund of State Key Laboratory of Nonlinear Mechanics
文摘Surface modification,as a promising approach to improve biocompatibility of biomaterials,has captured extensive close attention among many researchers.Here,micro-milling technology was used in constructing pyramid micro-structures on the surface of Ti-6Al-4Vimplant.Cutting parameters,including spindle speed,feed rate and depth of cut,were optimized to control the generation of burrs.In addition,low melting point alloy was selected to extend the boundary of the workpiece as supporting material to prevent the generation of top burrs.The surface topographies were characterized using scanning electron microscope and laser scanning microscope.Results showed that the dimension of burrs decreased with the decrease of depth of cut,and the size of burrs decreased with the increase of feed rate.Moreover,burrs nearly not appeared on both sides of the micro-grooves machined with low melting point alloy(LMPA)coating.Pyramid micro-structure on the workpiece surface was built successfully by combining optimized cutting parameters(S=35kr/min,Vf=60mm/min,ap=5μm)and LMPA coating.
