To the Editor：A 66-year-old male was seen in the outpatient clinics of Beijing Friendship Hospital with the complaint of right flank pain for the past 5 months.Computed tomography （CT）revealed the presence of adren...To the Editor：A 66-year-old male was seen in the outpatient clinics of Beijing Friendship Hospital with the complaint of right flank pain for the past 5 months.Computed tomography （CT）revealed the presence of adrenal masses [Figure la].Serum norepinephrine,epinephrine,and dopamine levels were normal,while cortisol,renin,and angiotensin levels were elevated.He was then admitted to the hospital.This patient had a history of controlled hypertension under drug treatment and noninsulin-dependent Type Ⅱ diabetes.展开更多
Dear Editor,Electroporation(EP)is a non-viral method for introducing macromolecules such as DNA,protein,and messenger RNA(mRNA)into mammalian cells for both basic research and ex vivo therapy(Glass et al.,2018).Due to...Dear Editor,Electroporation(EP)is a non-viral method for introducing macromolecules such as DNA,protein,and messenger RNA(mRNA)into mammalian cells for both basic research and ex vivo therapy(Glass et al.,2018).Due to its nature,EP offers great promise as a delivery method for gene therapy without causing risks associated with the viral vector-mediated delivery(Yin et al.,2017;Qiu et al.,2022).展开更多
文摘To the Editor：A 66-year-old male was seen in the outpatient clinics of Beijing Friendship Hospital with the complaint of right flank pain for the past 5 months.Computed tomography （CT）revealed the presence of adrenal masses [Figure la].Serum norepinephrine,epinephrine,and dopamine levels were normal,while cortisol,renin,and angiotensin levels were elevated.He was then admitted to the hospital.This patient had a history of controlled hypertension under drug treatment and noninsulin-dependent Type Ⅱ diabetes.
基金supported by the National Key Research and Development Program of China(2022YFF1002801 to Y.Z.,2019YFA0802801 and 2018YFA0801401 to H.Y.)the National Natural Science Foundation of China(31972936 to Y.Z.)+3 种基金Medical Science Advancement Program(Basic Medical Sciences)of Wuhan University(TFJC2018005)the Fundamental Research Funds for the Central Universities(to Y.Z.)the startup funding from Wuhan University(to Y.Z.)Y.Z.,H.Y.,C.-P.Z.,and J.A.have filed a patent application on buffer composition through Wuhan University(PCT International Application No.PCT/CN2022/106565)。
文摘Dear Editor,Electroporation(EP)is a non-viral method for introducing macromolecules such as DNA,protein,and messenger RNA(mRNA)into mammalian cells for both basic research and ex vivo therapy(Glass et al.,2018).Due to its nature,EP offers great promise as a delivery method for gene therapy without causing risks associated with the viral vector-mediated delivery(Yin et al.,2017;Qiu et al.,2022).
