Importance:Neonatal appendicitis(NA)is a rare and potentially fatal neonatal disease.However,misdiagnosis is common owing to atypical clinical manifestations and non-specific laboratory tests.Objective:The aim of this...Importance:Neonatal appendicitis(NA)is a rare and potentially fatal neonatal disease.However,misdiagnosis is common owing to atypical clinical manifestations and non-specific laboratory tests.Objective:The aim of this study was to summarize the clinical characteristics,treatments,and prognoses of infants with NA.Methods:This retrospective analysis included 69 patients diagnosed with NA admitted to Beijing Children’s Hospital between 1980 and 2019.The patients were divided into surgical and non-surgical groups based on whether surgery was performed.Their clinical characteristics were analyzed using the chi-square test,t-test,or the Mann-Whitney U test.Results:The study included 47 males and 22 females with NA.The primary symptoms were abdominal distension(n=36,52.2%),fever(n=19,27.5%),refusal to feed or decreased feeding(n=16,23.2%),and vomiting(n=15,21.7%).Sixty-five patients underwent abdominal ultrasound examinations;43 had definite appendiceal abnormalities,10 had right lower abdominal adhesive masses,and 14 had neonatal enterocolitis manifestations.Twenty-nine and 40 patients were in the surgical and non-surgical groups,respectively.No statistically significant differences were observed between the groups regarding sex,age at onset,birth weight,admission weight,or hospitalization time.However,parenteral nutrition was prolonged in the surgical group(P=0.001).Additionally,two patients(2.9%)died.Interpretation:NA is a rare neonatal disease with atypical clinical manifestations.Abdominal ultrasonography may aid in the diagnosis.Similarly,appropriate treatment can improve the prognosis.展开更多
文摘Importance:Neonatal appendicitis(NA)is a rare and potentially fatal neonatal disease.However,misdiagnosis is common owing to atypical clinical manifestations and non-specific laboratory tests.Objective:The aim of this study was to summarize the clinical characteristics,treatments,and prognoses of infants with NA.Methods:This retrospective analysis included 69 patients diagnosed with NA admitted to Beijing Children’s Hospital between 1980 and 2019.The patients were divided into surgical and non-surgical groups based on whether surgery was performed.Their clinical characteristics were analyzed using the chi-square test,t-test,or the Mann-Whitney U test.Results:The study included 47 males and 22 females with NA.The primary symptoms were abdominal distension(n=36,52.2%),fever(n=19,27.5%),refusal to feed or decreased feeding(n=16,23.2%),and vomiting(n=15,21.7%).Sixty-five patients underwent abdominal ultrasound examinations;43 had definite appendiceal abnormalities,10 had right lower abdominal adhesive masses,and 14 had neonatal enterocolitis manifestations.Twenty-nine and 40 patients were in the surgical and non-surgical groups,respectively.No statistically significant differences were observed between the groups regarding sex,age at onset,birth weight,admission weight,or hospitalization time.However,parenteral nutrition was prolonged in the surgical group(P=0.001).Additionally,two patients(2.9%)died.Interpretation:NA is a rare neonatal disease with atypical clinical manifestations.Abdominal ultrasonography may aid in the diagnosis.Similarly,appropriate treatment can improve the prognosis.
