In this paper, we extend a descent algorithm without line search for solving unconstrained optimization problems. Under mild conditions, its global convergence is established. Further, we generalize the search directi...In this paper, we extend a descent algorithm without line search for solving unconstrained optimization problems. Under mild conditions, its global convergence is established. Further, we generalize the search direction to more general form, and also obtain the global convergence of corresponding algorithm. The numerical results illustrate that the new algorithm is effective.展开更多
In this paper, we discuss the nonemptyness and boundedness of the solution set for P*-semidefinite complementarity problem by using the concept of exceptional family of elements for complementarity problems over the c...In this paper, we discuss the nonemptyness and boundedness of the solution set for P*-semidefinite complementarity problem by using the concept of exceptional family of elements for complementarity problems over the cone of semidefinite matrices, and obtain a main result that if the corresponding problem has a strict feasible point, then its solution set is nonemptyness and boundedness.展开更多
The highly conserved doublesex(dsx) and doublesex/mab-3 related(Dmrt) genes control sexually dimorphic traits across animals. The dsx gene encodes sex-specific transcription factors, Dsx^(M) in males and Dsx^(F) in fe...The highly conserved doublesex(dsx) and doublesex/mab-3 related(Dmrt) genes control sexually dimorphic traits across animals. The dsx gene encodes sex-specific transcription factors, Dsx^(M) in males and Dsx^(F) in females, which function differentially and often oppositely to establish sexual dimorphism. Here, we report that mutations in dsx, or overexpression of dsx, result in abnormal distribution of the basement membrane(BM) protein Collagen Ⅳ in the fat body. We find that Dsx isoforms regulate the expression of Collagen Ⅳ in the fat body and its secretion into the BM of other tissues. We identify the procollagen lysyl hydroxylase(dPlod) gene, which is involved in the biosynthesis of Collagen Ⅳ, as a direct target of Dsx. We further show that Dsx regulates Collagen Ⅳ through d Plod-dependent and independent pathways. These findings reveal how Dsx isoforms function in the secretory fat body to regulate Collagen Ⅳ and remotely establish sexual dimorphism.展开更多
Gender differences in behavior are prevalent among animal kingdoms. The causal links among a particular gene, neural circuitry, and gendered behaviors have long been of particular interest in neuroscience. The fruit f...Gender differences in behavior are prevalent among animal kingdoms. The causal links among a particular gene, neural circuitry, and gendered behaviors have long been of particular interest in neuroscience. The fruit fly, Drosophila melanogaster, is a wonderful animal model with fruitful genetic tools to tackle these questions(Guo et al., 2019). It has been found that two sex determination genes,fruitless(fru) and doublesex(dsx), jointly govern the sex differences in the nervous system that regulate the male-specific courtship behavior(Burtis and Baker, 1989;Ito et al., 1996;Ryner et al.展开更多
文摘In this paper, we extend a descent algorithm without line search for solving unconstrained optimization problems. Under mild conditions, its global convergence is established. Further, we generalize the search direction to more general form, and also obtain the global convergence of corresponding algorithm. The numerical results illustrate that the new algorithm is effective.
文摘In this paper, we discuss the nonemptyness and boundedness of the solution set for P*-semidefinite complementarity problem by using the concept of exceptional family of elements for complementarity problems over the cone of semidefinite matrices, and obtain a main result that if the corresponding problem has a strict feasible point, then its solution set is nonemptyness and boundedness.
基金supported by grants from National Key R&D Program of China (2019YFA0802400)the National Natural Science Foundation of China (31970943 and 31700905)the Jiangsu Innovation and Entrepreneurship Team Program
文摘The highly conserved doublesex(dsx) and doublesex/mab-3 related(Dmrt) genes control sexually dimorphic traits across animals. The dsx gene encodes sex-specific transcription factors, Dsx^(M) in males and Dsx^(F) in females, which function differentially and often oppositely to establish sexual dimorphism. Here, we report that mutations in dsx, or overexpression of dsx, result in abnormal distribution of the basement membrane(BM) protein Collagen Ⅳ in the fat body. We find that Dsx isoforms regulate the expression of Collagen Ⅳ in the fat body and its secretion into the BM of other tissues. We identify the procollagen lysyl hydroxylase(dPlod) gene, which is involved in the biosynthesis of Collagen Ⅳ, as a direct target of Dsx. We further show that Dsx regulates Collagen Ⅳ through d Plod-dependent and independent pathways. These findings reveal how Dsx isoforms function in the secretory fat body to regulate Collagen Ⅳ and remotely establish sexual dimorphism.
基金supported by grants from National Key R&D Program of China(2019YFA0802400)the National Natural Science Foundation of China(31970943 and 31700905)the Jiangsu Innovation and Entrepreneurship Team Program。
文摘Gender differences in behavior are prevalent among animal kingdoms. The causal links among a particular gene, neural circuitry, and gendered behaviors have long been of particular interest in neuroscience. The fruit fly, Drosophila melanogaster, is a wonderful animal model with fruitful genetic tools to tackle these questions(Guo et al., 2019). It has been found that two sex determination genes,fruitless(fru) and doublesex(dsx), jointly govern the sex differences in the nervous system that regulate the male-specific courtship behavior(Burtis and Baker, 1989;Ito et al., 1996;Ryner et al.
