Highly efficient and non-doped red conjugated polymer dot for photostable cell imaging

By introducing a naphthothiadiazole(NT)unit as the main building block,a non-doped and red emissive conjugated polymer poly(9,9-dihexylfluorene-alt-naphthothiadiazole)(PFNT)is readily obtained through a two-step synthesis.Since the NT unit has a large twist angle with its neighboring segment,the aggregation-induced quenching(AIQ)effect of PFNT can be effectively suppressed in the condensed state.As a result,the corresponding PFNT polymer dot(Pdot)exhibits a high fluorescence quantum yield of53.2%with peak emission at 616 nm,which is one of the most efficient red Pdots known.PFNT Pdot shows good biocompatibility and can be employed for living cell fluorescent imaging with high brightness.It also can be used for specific subcellular organelle imaging through immunofluorescence labeling.Furthermore,the PFNT Pdot demonstrates much better photostability for long-time cell fluorescence imaging than commercial red dyes.The high performances of PFNT Pdot make it a promising fluorescent probe for practical bioapplications.

Progress on intelligent hydrogels based on RAFT polymerization:Design strategy, fabrication and the applications for controlled drug delivery

Although intelligent hydrogels have shown bright potential application in biomedical fields,they were prepared by conventional methods and still face many serious challenges,such as uncontrollable stimulus-response and low response sensitivity.Recently,RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties,owing to the ability to efficiently construct hydrogel precursors with well-defined structure,such as block copolymer,graft copolymer,star copolymer.In this review,we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery.

Whole wheat flour coating with antioxidant property accelerates tissue remodeling for enhanced wound healing

As a daily food for billions of people for thousands of years,whole grain is rich in phenolic compounds and may have huge potentials to provide natural antioxidants.Herein,owing to the significant biomedical potential,the effect of whole wheat flour solution as antioxidant wound coating for enhanced wound healing has been studied.The results show that the low concentration of whole wheat flour solutions have good biocompatibility and can scavenge radical and intracellular ROS in vitro,accelerating tissue remodeling in vivo to promote wound healing.This kind of whole wheat flour solution has great potential application for cutaneous wound repair.