Pulmonary Drugs and Genes Delivery Systems for Lung Disease Treatment

Pulmonary drugs and genes delivery systems have become an attractive approach in the treatment of lung diseases with the advantages of minimal drug loss,precise quantization,high local drugs concentration and low side effects.However,special attention should be paid to the biological barriers of the lung.The delivery systems need to be designed carefully in order to overcome these biological barriers and maximize the drugs and genes deposition to the lungs.Pulmonary drugs and genes delivery systems can offer some encouraging results for delivering drugs and genes to the lungs.Specifically,some lipid-based and polymer-based delivery systems could control and sustain the release of drugs and genes with minimal or negligible toxicity.This review focuses on the latest development of pulmonary delivery of drugs and genes for the treatment of various lung diseases.The barriers to the lung,the delivery devices,the route of the administration and the delivery systems for drugs and genes pulmonary delivery are described.Based on the rapid development of clinical requirement,novel approaches using delivery systems for pulmonary delivery drugs and genes need to be constructed,which is believed to play an important role in the therapy of lung diseases in the future.

Recent progress in cationic polymeric gene carriers for cancer therapy

In recent years,various carriers for gene delivery nave been developed for biomedical applications.Among all kinds of gene carriers,cationic polymeric carriers for delivery therapeutic gene as non-viral carriers have received growing interests due to their improved high transfection efficiency with the relative safety.In particular,the advancement of novel polymeric gene carriers has gained much progress in the development of effective anticancer therapy.Herein,this review focused on the development of cationic polymeric carriers for cancer therapy,including polyethylenimine(PEI),polyamidoamine(PAMAM) dendrimers,polylysine(PLL),chitosan and modified cationic polymers.And recent progresses in the development of novel polymeric carriers for gene delivery,such as targeted gene carriers,responsive gene carriers and multifunctional gene carriers,were summarized.Finally,the future perspectives in the development of novel polymeric carriers for delivery gene were presented.

Dual Reactive Oxygen Species Generator Independent of Light and Oxygen for Tumor Imaging and Catalytic Therapy

Currently,reactive oxygen species(ROS)generation primarily depends upon light and O2,which hampers its further biomedical application.Here,we report that amanganese(Ⅲ)salen-based complex(MnS)can continuously catalyze overexpressed hydrogen peroxide(H_(2)O_(2))in the tumor microenvironment to ^(1)O_(2),while the nanocarrier(MIL-100)as a Fenton reagent can convert H_(2)O_(2) to hydroxyl radicals(·OH)through the Fenton reaction,inducing noticeable intracellular DNA strand scission and lipid peroxidation to provoke tumor cell apoptosis without the involvement of light and O_(2).Moreover,MIL-100 depleted the antioxidant glutathione,further amplifying intracellular oxidative pressure,which in turn led to the self-degradation of MIL-100,suggesting the long-term biosafety of the nanoplatform.Owing to the excellent magnetic resonance imaging performance of MnS,the diagnosis and specific treatment of tumors were eventually achieved.This work provides a novel approach for the realization of effective tumor catalytic therapy independent of light and O_(2) and a promising reference for the development of a wide range of catalytic therapeutic agents.