The Cu-Fe/AC catalyst was prepared by microwave-assisted synthesis, and its morphological characteristics were characterized. The degradation effect of phenol wastewater by catalytic wet peroxide oxidation(CWPO) was s...The Cu-Fe/AC catalyst was prepared by microwave-assisted synthesis, and its morphological characteristics were characterized. The degradation effect of phenol wastewater by catalytic wet peroxide oxidation(CWPO) was studied, and the response surface methodology(RSM) was used to analyze the influencing factors of the removal rate of COD. The experimental results showed that under the conditions of reaction temperature 80 ℃, reaction time 90 min, initial pH 3.1 and H_(2)O_(2)addition 2.2 g/L, the removal rate of COD reached 82%. The results of response surface methodology indicated that under the conditions of reaction temperature 100 ℃, reaction time 64 min, initial pH 3.3 and H_(2)O_(2)addition 2.7 g/L, the removal rate of COD was up to 86%. After Cu-Fe/AC catalyst was reused for 4 times, the removal rate of COD was still above 80%, revealing that the catalyst showed good catalytic performance.展开更多
Aims:Few studies have investigated differences in sequential transarterial chemoembolization(TACE),radiofrequency ablation(RFA),and simultaneous RFA-TACE for the treatment of hepatocellular carcinoma(HCC)using the Mil...Aims:Few studies have investigated differences in sequential transarterial chemoembolization(TACE),radiofrequency ablation(RFA),and simultaneous RFA-TACE for the treatment of hepatocellular carcinoma(HCC)using the Milan criteria.This study explored the differences in safety and prognosis between sequential TACE-RFA and simultaneous RFA-TACE.Methods:This retrospective real-world study included 109 patients with HCC within the Milan criteria who underwent sequential TACE-RFA(n=75)or simultaneous RFA-TACE(n=34)at the Eastern Hepatobiliary Surgery Hospital between January 2017 and 2021.Postoperative complications,length of hospital stay,and long-term prognosis were compared.The median follow-up duration of these patients was 39.1 months.Overall survival(OS)and time to tumor recurrence(TTR)curves were plotted using the Kaplan−Meier method and were compared using the logarithmic rank test.Independent risk factors for OS and tumor recurrence(TR)were analyzed using the Cox risk regression model.Results:Multivariate analysis showed that tumor diameter>3 cm(hazard ratio[HR]:2.201,95%confidence interval[CI]:1.106-4.378,p=0.025;HR:2.236,95%CI:1.271-3.934,p=0.005,respectively)and alphafetoprotein(AFP)>400μg/L(HR:2.362,95%CI:1.195-4.668,p=0.013;HR:1.798,95%CI:1.048-3.086,p=0.033,respectively)were independent risk factors for OS and TTR,whereas the presence of multiple tumors(HR:2.352,95%CI:1.127-4.907,p=0.023)was an independent risk factor for TTR.Simultaneous RFA-TACE did not have an effect on OS or TTR.After propensity score-matched,comparable results were obtained and RFATACE still had no effect on OS or TTR.No significant differences were observed in grade III/IV complications(2/75[2.7%]vs.1/34[2.9%],p=1.000)between the two groups.However,the RFA-TACE group had fewer complications than the TACE-RFA group(24/34[70.6%]vs.66/75[88.0%],p=0.026).The RFA-TACE group had a shorter hospital stay and less total cost during hospitalization compared with the TACE-RFA group(6.0 vs.10.0 days,p<0.001;30,000 vs.35,000 CNY,p<0.001).Conclusions:For HCC within the Milan criteria,there was no significant difference in OS and TTR between RFA-TACE and TACE-RFA.However,RFA-TACE could reduce all-grade complications and shorten the length of hospital stay compared with TACE-RFA.Therefore,simultaneous RFA-TACE may be considered for patients with HCC and good liver function falling within the Milan criteria.展开更多
文摘The Cu-Fe/AC catalyst was prepared by microwave-assisted synthesis, and its morphological characteristics were characterized. The degradation effect of phenol wastewater by catalytic wet peroxide oxidation(CWPO) was studied, and the response surface methodology(RSM) was used to analyze the influencing factors of the removal rate of COD. The experimental results showed that under the conditions of reaction temperature 80 ℃, reaction time 90 min, initial pH 3.1 and H_(2)O_(2)addition 2.2 g/L, the removal rate of COD reached 82%. The results of response surface methodology indicated that under the conditions of reaction temperature 100 ℃, reaction time 64 min, initial pH 3.3 and H_(2)O_(2)addition 2.7 g/L, the removal rate of COD was up to 86%. After Cu-Fe/AC catalyst was reused for 4 times, the removal rate of COD was still above 80%, revealing that the catalyst showed good catalytic performance.
基金The State Key Project on Infectious Diseases of China,Grant/Award Number:2018ZX10723204-001The Joint Tackling Project of Emerging Frontier Technologies in Shanghai Hospitals in 2017,Grant/Award Number:SHDC12017122+3 种基金The Clinical Research Plan for SHDC,Grant/Award Number:SHDC2020CR2038BThe Explorer Program of Shanghai Scientific and Technological Committee,Grant/Award Number:21TS1400500The Scientific Research Project of Shanghai Municipal Health Commission,Grant/Award Number:20234Y0151The Program of Science and Technology Commission of Shanghai Municipality,Grant/Award Number:21Y11912700。
文摘Aims:Few studies have investigated differences in sequential transarterial chemoembolization(TACE),radiofrequency ablation(RFA),and simultaneous RFA-TACE for the treatment of hepatocellular carcinoma(HCC)using the Milan criteria.This study explored the differences in safety and prognosis between sequential TACE-RFA and simultaneous RFA-TACE.Methods:This retrospective real-world study included 109 patients with HCC within the Milan criteria who underwent sequential TACE-RFA(n=75)or simultaneous RFA-TACE(n=34)at the Eastern Hepatobiliary Surgery Hospital between January 2017 and 2021.Postoperative complications,length of hospital stay,and long-term prognosis were compared.The median follow-up duration of these patients was 39.1 months.Overall survival(OS)and time to tumor recurrence(TTR)curves were plotted using the Kaplan−Meier method and were compared using the logarithmic rank test.Independent risk factors for OS and tumor recurrence(TR)were analyzed using the Cox risk regression model.Results:Multivariate analysis showed that tumor diameter>3 cm(hazard ratio[HR]:2.201,95%confidence interval[CI]:1.106-4.378,p=0.025;HR:2.236,95%CI:1.271-3.934,p=0.005,respectively)and alphafetoprotein(AFP)>400μg/L(HR:2.362,95%CI:1.195-4.668,p=0.013;HR:1.798,95%CI:1.048-3.086,p=0.033,respectively)were independent risk factors for OS and TTR,whereas the presence of multiple tumors(HR:2.352,95%CI:1.127-4.907,p=0.023)was an independent risk factor for TTR.Simultaneous RFA-TACE did not have an effect on OS or TTR.After propensity score-matched,comparable results were obtained and RFATACE still had no effect on OS or TTR.No significant differences were observed in grade III/IV complications(2/75[2.7%]vs.1/34[2.9%],p=1.000)between the two groups.However,the RFA-TACE group had fewer complications than the TACE-RFA group(24/34[70.6%]vs.66/75[88.0%],p=0.026).The RFA-TACE group had a shorter hospital stay and less total cost during hospitalization compared with the TACE-RFA group(6.0 vs.10.0 days,p<0.001;30,000 vs.35,000 CNY,p<0.001).Conclusions:For HCC within the Milan criteria,there was no significant difference in OS and TTR between RFA-TACE and TACE-RFA.However,RFA-TACE could reduce all-grade complications and shorten the length of hospital stay compared with TACE-RFA.Therefore,simultaneous RFA-TACE may be considered for patients with HCC and good liver function falling within the Milan criteria.
