Hypoxia,or the lack of oxygen,has multiple impacts on the vascular system.The major molecular sensors for hypoxia at the cellular level are hypoxia inducible factor and heme oxygenase.Hypoxia also acts on the vasculat...Hypoxia,or the lack of oxygen,has multiple impacts on the vascular system.The major molecular sensors for hypoxia at the cellular level are hypoxia inducible factor and heme oxygenase.Hypoxia also acts on the vasculature directly conveying its damaging effects through disruption of the control of vascular tone,particularly in the coronary circulation,enhancement of inflammatory responses and activation of coagulation pathways.These effects could be particularly detrimental under pathological conditions such as obstructive sleep apnea and other breathing disorders.展开更多
基金The current research is supported by the Hong Kong Research Grant Council(University of Hong Kong,No.780410M)by the Research Centre of Heart,Brain,Hormone and Healthy Aging of the University of Hong Kongby the World Class University program(R31-20029)funded by the Ministry of Education,Science and Technology,South Korea.
文摘Hypoxia,or the lack of oxygen,has multiple impacts on the vascular system.The major molecular sensors for hypoxia at the cellular level are hypoxia inducible factor and heme oxygenase.Hypoxia also acts on the vasculature directly conveying its damaging effects through disruption of the control of vascular tone,particularly in the coronary circulation,enhancement of inflammatory responses and activation of coagulation pathways.These effects could be particularly detrimental under pathological conditions such as obstructive sleep apnea and other breathing disorders.
