The low solubility of ethyl p-methoxycinnamate(EPMC)inhibits its absorption in the gastrointestinal tract,impairing its pharmacological effect.The solubility of EPMC can be increased by utilizing a carrier in the type...The low solubility of ethyl p-methoxycinnamate(EPMC)inhibits its absorption in the gastrointestinal tract,impairing its pharmacological effect.The solubility of EPMC can be increased by utilizing a carrier in the type of mesoporous silica nanoparticles(MSN).In the present study,we aimed to confine EPMC under the nanoscale of MSN(MSN-EPMC)to increase the water solubility of EPMC.MSN was prepared using sodium silica as a precursor and Tween 80 and Span 80 as templates.Briefly,500 mg MSN was dispersed into 2%w/v EPMC solution,stirred at 100 r/min for 24 h,and dried at 60℃.The results showed that the MSN formed had a particle size of 87.1305 nm,a surface area of 68.86 m;/g,a pore diameter of 20.45 nm,and a pore volume of 0.352 cm;/g.EPMC was successfully confined under the nanoscale of MSN.MSN-EPMC had an amorphous structure,a loading capacity of 10.6%,and a loading efficiency of 18.18%.The solubility of MSN-EPMC was increased by 2.63 folds at 30 min compared with EPMC.The amorphous structure of MSN-EPMC was responsible for the enhancement of the water solubility.It could be concluded that the confining of EPMC in MSN had the potential to increase the solubility of a water-soluble isolate of a plant.展开更多
基金The authors gratefully acknowledge the financial support of the Ministry of Education and Culture for funding this research through the Research and Technology Grant Program/National Research and Innovation Agency Number:1827/UN6.3.1/LT/2020.
文摘The low solubility of ethyl p-methoxycinnamate(EPMC)inhibits its absorption in the gastrointestinal tract,impairing its pharmacological effect.The solubility of EPMC can be increased by utilizing a carrier in the type of mesoporous silica nanoparticles(MSN).In the present study,we aimed to confine EPMC under the nanoscale of MSN(MSN-EPMC)to increase the water solubility of EPMC.MSN was prepared using sodium silica as a precursor and Tween 80 and Span 80 as templates.Briefly,500 mg MSN was dispersed into 2%w/v EPMC solution,stirred at 100 r/min for 24 h,and dried at 60℃.The results showed that the MSN formed had a particle size of 87.1305 nm,a surface area of 68.86 m;/g,a pore diameter of 20.45 nm,and a pore volume of 0.352 cm;/g.EPMC was successfully confined under the nanoscale of MSN.MSN-EPMC had an amorphous structure,a loading capacity of 10.6%,and a loading efficiency of 18.18%.The solubility of MSN-EPMC was increased by 2.63 folds at 30 min compared with EPMC.The amorphous structure of MSN-EPMC was responsible for the enhancement of the water solubility.It could be concluded that the confining of EPMC in MSN had the potential to increase the solubility of a water-soluble isolate of a plant.
