期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Immunology of a unique biological structure:the Echinococcus laminated layer 被引量:1
1
作者 Álvaro Díaz Anabella ABarrios +4 位作者 Leticia Grezzi camila mouhape Stephen J.Jenkins Judith E.Allen Cecilia Casaravilla 《Protein & Cell》 SCIE CSCD 2023年第2期87-104,共18页
The larval stages of the cestode parasites belonging to the genus Echinococcus grow within internal organs of humans and a range of animal species.The resulting diseases,collectively termed echinococcoses,include majo... The larval stages of the cestode parasites belonging to the genus Echinococcus grow within internal organs of humans and a range of animal species.The resulting diseases,collectively termed echinococcoses,include major neglected tropical diseases of humans and livestock.Echinococcus larvae are outwardly protected by the laminated layer(LL),an acellular structure that is unique to this genus.The LL is based on a fibrillar meshwork made up of mucins,which are decorated by galactose-rich O-glycans.In addition,in the species cluster termed E.granulosus sensu lato,the LL features nano-deposits of the calcium salt of myo-inositol hexakisphosphate(Insp_(6)).The main purpose of our article is to update the immunobiology of the LL.Major recent advances in this area are(i)the demonstration of LL“debris”at the infection site and draining lymph nodes,(ii)the characterization of the decoy activity of calcium Inp6 with respect to complement,(iii)the evidence that the LL mucin carbohydrates interact specifically with a lectin receptor expressed in Kupffer cells(Clec4F),and(iv)the characterization of what appear to be receptor-independent effects of LL particles on dendritic cells and macrophages.Much information is missing on the immunology of this intriguing structure:we discuss gaps in knowledge and propose possible avenues for research. 展开更多
关键词 MUCIN COMPLEMENT ECHINOCOCCUS MACROPHAGE dendritic cell Clec4F
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部