Approximate Iteration Detection and Precoding in Massive MIMO

Massive multiple-input multiple-output provides improved energy efficiency and spectral efficiency in 5 G. However it requires large-scale matrix computation with tremendous complexity, especially for data detection and precoding. Recently, many detection and precoding methods were proposed using approximate iteration methods, which meet the demand of precision with low complexity. In this paper, we compare these approximate iteration methods in precision and complexity, and then improve these methods with iteration refinement at the cost of little complexity and no extra hardware resource. By derivation, our proposal is a combination of three approximate iteration methods in essence and provides remarkable precision improvement on desired vectors. The results show that our proposal provides 27%-83% normalized mean-squared error improvement of the detection symbol vector and precoding symbol vector. Moreover, we find the bit-error rate is mainly controlled by soft-input soft-output Viterbi decoding when using approximate iteration methods. Further, only considering the effect on soft-input soft-output Viterbi decoding, the simulation results show that using a rough estimation for the filter matrix of minimum mean square error detection to calculating log-likelihood ratio could provideenough good bit-error rate performance, especially when the ratio of base station antennas number and the users number is not too large.

Knockdown of HMGB1 improves apoptosis and suppresses proliferation and invasion of glioma cells

Background： Effective methods for managing patients with solitary pulmonary nodules（SPNs） depend critically on the predictive probability of malignancy.Methods： Between July 2009 and June 2011, data on gender, age, cancer history, tumor familial history, smoking status, tumor location, nodule size, spiculation, calcification, the tumor border, and the final pathological diagnosis were collected retrospectively from 154 surgical patients with an SPN measuring 3-30 mm. Each final diagnosis was compared with the probability calculated by three predicted models—the Mayo, VA, and Peking University（PU） models. The accuracy of each model was assessed using area under the receiver operating characteristics（ROC） and calibration curves.Results： The area under the ROC curve of the PU model [0.800; 95% confidence interval（CI）： 0.708-0.891] was higher than that of the Mayo model（0.753; 95% CI： 0.650-0.857） or VA model（0.728; 95% CI： 0.623-0.833）; however, this finding was not statistically significant. To varying degrees, calibration curves showed that all three models overestimated malignancy.Conclusions： The three predicted models have similar accuracy for prediction of SPN malignancy, although the accuracy is not sufficient. For Chinese patients, the PU model may has greater predictive power.Background： Here, we introduced our short experience on the application of a new CUSA Excel ultrasonic aspiration system, which was provided by Integra Lifesciences corporation, in skull base meningiomas resection.Methods： Ten patients with anterior, middle skull base and sphenoid ridge meningioma were operated using the CUSA Excel ultrasonic aspiration system at the Neurosurgery Department of Shanghai Huashan Hospital from August 2014 to October 2014. There were six male and four female patients, aged from 38 to 61 years old（the mean age was 48.5 years old）. Five cases with tumor located at anterior skull base, three cases with tumor on middle skull base, and two cases with tumor on sphenoid ridge.Results： All the patents received total resection of meningiomas with the help of this new tool, and the critical brain vessels and nerves were preserved during operations. All the patients recovered well after operation.Conclusions： This new CUSA Excel ultrasonic aspiration system has the advantage of preserving vital brain arteries and cranial nerves during skull base meningioma resection, which is very important for skull base tumor operations. This key step would ensure a well prognosis for patients. We hope the neurosurgeons would benefit from this kind of technique.Background： The purposes of this study were to explore the effects of high mobility group protein box 1（HMGB1） gene on the growth, proliferation, apoptosis, invasion, and metastasis of glioma cells, with an attempt to provide potential therapeutic targets for the treatment of glioma. Methods： The expressions of HMGB1 in glioma cells（U251, U-87 MG and LN-18） and one control cell line（SVG p12） were detected by real time PCR and Western blotting, respectively. Then, the effects of HMGB1 on the biological behaviors of glioma cells were detected： the expression of HMGB1 in human glioma cell lines U251 and U-87 MG were suppressed using RNAi technique, then the influences of HMGB1 on the viability, cycle, apoptosis, and invasion abilities of U251 and U-87 MG cells were analyzed using in a Transwell invasion chamber. Also, the effects of HMGB1 on the expressions of cyclin D1, Bax, Bcl-2, and MMP 9 were detected. Results： As shown by real-time PCR and Western blotting, the expression of HMGB1 significantly increased in glioma cells（U251, U-87 MG, and LN-18） in comparison with the control cell line（SVG p12）; the vitality, proliferation and invasive capabilities of U251 and U-87 MG cells in the HMGB1 siR NA-transfected group were significantly lower than those in the blank control group and negative control（NC） siR NA group（P〈0.05） but showed no significant difference between the blank control group and NC siR NA group. The percentage of apoptotic U251 and U-87 MG cells was significantly higher in the HMGB1 siR NA-transfected group than in the blank control group and NC siR NA group（P〈0.05） but was similar between the latter two groups. The HMGB1 siR NA-transfected group had significantly lower expression levels of Cyclin D1, Bcl-2, and MMP-9 protein in U251 and U-87 MG cells and significantly higher expression of Bax protein than in the blank control group and NC siR NA group（P〈0.05）; the expression profiles of cyclin D1, Bax, Bcl-2, and MMP 9 showed no significant change in both blank control group and NC siR NA group. Conclusions： HMGB1 gene may promote the proliferation and migration of glioma cells and suppress its effects of apoptosis. Inhibition of the expression of HMGB1 gene can suppress the proliferation and migration of glioma cells and promote their apoptosis. Our observations provided a new target for intervention and treatment of glioma.

CWLP:coordinated warp scheduling and locality-protected cache allocation on GPUs

As we approach the exascale era in supercomputing, designing a balanced computer system with a powerful computing ability and low power requirements has becoming increasingly important. The graphics processing unit（GPU） is an accelerator used widely in most of recent supercomputers. It adopts a large number of threads to hide a long latency with a high energy efficiency. In contrast to their powerful computing ability, GPUs have only a few megabytes of fast on-chip memory storage per streaming multiprocessor（SM）. The GPU cache is inefficient due to a mismatch between the throughput-oriented execution model and cache hierarchy design. At the same time, current GPUs fail to handle burst-mode long-access latency due to GPU＇s poor warp scheduling method.Thus, benefits of GPU＇s high computing ability are reduced dramatically by the poor cache management and warp scheduling methods, which limit the system performance and energy efficiency. In this paper, we put forward a coordinated warp scheduling and locality-protected（CWLP） cache allocation scheme to make full use of data locality and hide latency. We first present a locality-protected cache allocation method based on the instruction program counter（LPC） to promote cache performance. Specifically, we use a PC-based locality detector to collect the reuse information of each cache line and employ a prioritised cache allocation unit（PCAU） which coordinates the data reuse information with the time-stamp information to evict the lines with the least reuse possibility. Moreover, the locality information is used by the warp scheduler to create an intelligent warp reordering scheme to capture locality and hide latency. Simulation results show that CWLP provides a speedup up to 19.8% and an average improvement of 8.8% over the baseline methods.