This paper was concerned with the tensile mechanics behavior of the composite π-joint under static tensile loading. The numerical strength analysis methodology was presented containing the basis assumption for the an...This paper was concerned with the tensile mechanics behavior of the composite π-joint under static tensile loading. The numerical strength analysis methodology was presented containing the basis assumption for the analysis, the material modeling, and the selected element type. It was assumed that the composite ply had transverse isotropic material properties and the adhesive had linear elastic properties. With the goal of the strength analysis to determine the onset of the damage initiation and the ultimate failure load, two stiffness degradation models were discussed and a modified maximum stress failure criteria was presented. To verify the numerical model, a pull-off test scheme was performed and the experimental data of five specimens were given. The experimental results indicate that the damage initiation location and the failure load were consistent with numerical predictions and verified the feasibility of the numerical model.展开更多
目的:基于网络药理学探讨苓桂术甘汤治疗眩晕病的潜在作用机制。方法:通过中药系统药理学数据库与分析平台、蛋白质数据库(universal protein,UniProt)及Swiss Target Prediction数据库获取有效活性成分及潜在靶点;借助人类基因数据库(G...目的:基于网络药理学探讨苓桂术甘汤治疗眩晕病的潜在作用机制。方法:通过中药系统药理学数据库与分析平台、蛋白质数据库(universal protein,UniProt)及Swiss Target Prediction数据库获取有效活性成分及潜在靶点;借助人类基因数据库(Genecards)、在线人类孟德尔遗传数据库及DRUGBANK数据库获取眩晕病已知靶点,整合分析苓桂术甘汤作用于眩晕病的靶点;采用Cytoscape_v3.7.2软件进行网络可视化及蛋白相互作用分析数据库(STRING)绘制蛋白质相互作用网络;采用Metascape平台对其进行基因功能和作用通路富集分析;采用AutoDock软件进行分子对接验证;采用HPA(the human protein atlas)数据库对其核心基因进行免疫组织化学分析。结果:获得苓桂术甘汤有效活性成分103个,关键成分97个,得到预测靶点212个,复方作用于疾病的交集靶点114个,包括白细胞介素-6、RAC-α丝氨酸/苏氨酸蛋白激酶、肿瘤坏死因子、血管内皮生长因子A等;基因本体功能富集分析发现:生物过程2031个、细胞组分93个、分子功能151个,包括活性氧代谢过程、对脂多糖的反应等;京都基因和基因组百科全书通路富集分析发现:信号通路304条,主要包括癌症的途径、白细胞介素-17信号通路、HIF-1信号通路等;分子对接结果表明:苓桂术甘汤的核心活性成分与治疗眩晕病的关键靶点可以紧密结合;免疫组织化学分析结果表明:苓桂术甘汤在大脑皮层对眩晕病起到治疗作用。结论:苓桂术甘汤治疗眩晕病通过核心靶点--白细胞介素-6、RAC-α丝氨酸/苏氨酸蛋白激酶、肿瘤坏死因子、血管内皮生长因子A等参与白细胞介素-17信号通路、HIF-1信号通路、p53信号通路的调控,可能与调控中枢神经炎症,保护及重塑脑神经和调节脑组织有关。展开更多
文摘This paper was concerned with the tensile mechanics behavior of the composite π-joint under static tensile loading. The numerical strength analysis methodology was presented containing the basis assumption for the analysis, the material modeling, and the selected element type. It was assumed that the composite ply had transverse isotropic material properties and the adhesive had linear elastic properties. With the goal of the strength analysis to determine the onset of the damage initiation and the ultimate failure load, two stiffness degradation models were discussed and a modified maximum stress failure criteria was presented. To verify the numerical model, a pull-off test scheme was performed and the experimental data of five specimens were given. The experimental results indicate that the damage initiation location and the failure load were consistent with numerical predictions and verified the feasibility of the numerical model.
文摘目的:基于网络药理学探讨苓桂术甘汤治疗眩晕病的潜在作用机制。方法:通过中药系统药理学数据库与分析平台、蛋白质数据库(universal protein,UniProt)及Swiss Target Prediction数据库获取有效活性成分及潜在靶点;借助人类基因数据库(Genecards)、在线人类孟德尔遗传数据库及DRUGBANK数据库获取眩晕病已知靶点,整合分析苓桂术甘汤作用于眩晕病的靶点;采用Cytoscape_v3.7.2软件进行网络可视化及蛋白相互作用分析数据库(STRING)绘制蛋白质相互作用网络;采用Metascape平台对其进行基因功能和作用通路富集分析;采用AutoDock软件进行分子对接验证;采用HPA(the human protein atlas)数据库对其核心基因进行免疫组织化学分析。结果:获得苓桂术甘汤有效活性成分103个,关键成分97个,得到预测靶点212个,复方作用于疾病的交集靶点114个,包括白细胞介素-6、RAC-α丝氨酸/苏氨酸蛋白激酶、肿瘤坏死因子、血管内皮生长因子A等;基因本体功能富集分析发现:生物过程2031个、细胞组分93个、分子功能151个,包括活性氧代谢过程、对脂多糖的反应等;京都基因和基因组百科全书通路富集分析发现:信号通路304条,主要包括癌症的途径、白细胞介素-17信号通路、HIF-1信号通路等;分子对接结果表明:苓桂术甘汤的核心活性成分与治疗眩晕病的关键靶点可以紧密结合;免疫组织化学分析结果表明:苓桂术甘汤在大脑皮层对眩晕病起到治疗作用。结论:苓桂术甘汤治疗眩晕病通过核心靶点--白细胞介素-6、RAC-α丝氨酸/苏氨酸蛋白激酶、肿瘤坏死因子、血管内皮生长因子A等参与白细胞介素-17信号通路、HIF-1信号通路、p53信号通路的调控,可能与调控中枢神经炎症,保护及重塑脑神经和调节脑组织有关。
