Background: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) h ave been found in approximately 40%of patients with generalized myasthenia grav is who are seronegative for the antiacetylcholine receptor ...Background: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) h ave been found in approximately 40%of patients with generalized myasthenia grav is who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weak ness of the neck and respiratory muscles, but patients with ocular myasthenia ha ve not been described. Objective: To report a case of ocular myasthenia due to a nti-MuSK antibodies. Patient: A young woman with ocular myasthenia and antibodi es to MuSK. Results: Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen. Conclusion: Ocular myasthenia gravis i s a presentation of the anti-MuSK antibody syndrome.展开更多
文摘Background: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) h ave been found in approximately 40%of patients with generalized myasthenia grav is who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weak ness of the neck and respiratory muscles, but patients with ocular myasthenia ha ve not been described. Objective: To report a case of ocular myasthenia due to a nti-MuSK antibodies. Patient: A young woman with ocular myasthenia and antibodi es to MuSK. Results: Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen. Conclusion: Ocular myasthenia gravis i s a presentation of the anti-MuSK antibody syndrome.
